Good Brain News - by The Dementia League
@dementialeague.bsky.social
Fighting #dementia, #Alzheimers, & other degenerative conditions by sharing #brain health #science. Supporting the challenges of #caregiving. #Research #news summarized by experts. Join us & share! Not #medical advice. #NonProfit. South Bend, IN. #memory
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This innovative approach could pave the way for new strategies in combating AD, emphasizing the importance of interdisciplinary research in neurodegenerative diseases. 🧠
📰 ht*tps://pubmed.ncbi.nlm.nih.gov/41200152/
image from ht*tps://encyclopedia.pub/entry/28723
This innovative approach could pave the way for new strategies in combating AD, emphasizing the importance of interdisciplinary research in neurodegenerative diseases. 🧠
📰 ht*tps://pubmed.ncbi.nlm.nih.gov/41200152/
image from ht*tps://encyclopedia.pub/entry/28723
November 18, 2025 at 10:15 PM
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This innovative approach could pave the way for new strategies in combating AD, emphasizing the importance of interdisciplinary research in neurodegenerative diseases. 🧠
📰 ht*tps://pubmed.ncbi.nlm.nih.gov/41200152/
image from ht*tps://encyclopedia.pub/entry/28723
This innovative approach could pave the way for new strategies in combating AD, emphasizing the importance of interdisciplinary research in neurodegenerative diseases. 🧠
📰 ht*tps://pubmed.ncbi.nlm.nih.gov/41200152/
image from ht*tps://encyclopedia.pub/entry/28723
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- Both Aβ and tau exhibit pathogenic seed-like behavior similar to prion proteins (PrP).
- Understanding these mechanisms may lead to precision therapeutics targeting AD.
- The research highlights the potential for developing treatments that disrupt the aggregation process.
- Both Aβ and tau exhibit pathogenic seed-like behavior similar to prion proteins (PrP).
- Understanding these mechanisms may lead to precision therapeutics targeting AD.
- The research highlights the potential for developing treatments that disrupt the aggregation process.
November 18, 2025 at 10:15 PM
2/3
- Both Aβ and tau exhibit pathogenic seed-like behavior similar to prion proteins (PrP).
- Understanding these mechanisms may lead to precision therapeutics targeting AD.
- The research highlights the potential for developing treatments that disrupt the aggregation process.
- Both Aβ and tau exhibit pathogenic seed-like behavior similar to prion proteins (PrP).
- Understanding these mechanisms may lead to precision therapeutics targeting AD.
- The research highlights the potential for developing treatments that disrupt the aggregation process.
3/3
This suggests that puerarin might be a promising treatment for diet-related cognitive issues.
Learn more: buff.ly/Em5Px3R
This suggests that puerarin might be a promising treatment for diet-related cognitive issues.
Learn more: buff.ly/Em5Px3R
Puerarin Alleviates High-fat High-sugar Diet-induced Alzheimer's Disease-like Pathology and Insulin Resistance in Mice by Inhibiting p35/CDK5-mediated Mitochondrial Fission - PubMed
Puerarin has demonstrated protective effects against Alzheimer's disease (AD) and diabetes. This study aimed to explore the therapeutic potential and mechanistic basis of puerarin against high-fat…
buff.ly
November 16, 2025 at 10:45 PM
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This suggests that puerarin might be a promising treatment for diet-related cognitive issues.
Learn more: buff.ly/Em5Px3R
This suggests that puerarin might be a promising treatment for diet-related cognitive issues.
Learn more: buff.ly/Em5Px3R
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In tests with mice and cells, puerarin improved brain function and reduced harmful proteins linked to Alzheimer's. It works by blocking a specific protein pathway involved in brain and metabolic health.
In tests with mice and cells, puerarin improved brain function and reduced harmful proteins linked to Alzheimer's. It works by blocking a specific protein pathway involved in brain and metabolic health.
Puerarin Alleviates High-fat High-sugar Diet-induced Alzheimer's Disease-like Pathology and Insulin Resistance in Mice by Inhibiting p35/CDK5-mediated Mitochondrial Fission - PubMed
Puerarin has demonstrated protective effects against Alzheimer's disease (AD) and diabetes. This study aimed to explore the therapeutic potential and mechanistic basis of puerarin against high-fat…
buff.ly
November 16, 2025 at 10:45 PM
2/3
In tests with mice and cells, puerarin improved brain function and reduced harmful proteins linked to Alzheimer's. It works by blocking a specific protein pathway involved in brain and metabolic health.
In tests with mice and cells, puerarin improved brain function and reduced harmful proteins linked to Alzheimer's. It works by blocking a specific protein pathway involved in brain and metabolic health.
3/3
This integrative approach enhances our understanding of AD's molecular mechanisms, paving the way for targeted therapeutic strategies and improved diagnostics. #endalz #brainhealth #neuroscience
📰 pubmed.ncbi.nlm.nih.gov/41201155/
This integrative approach enhances our understanding of AD's molecular mechanisms, paving the way for targeted therapeutic strategies and improved diagnostics. #endalz #brainhealth #neuroscience
📰 pubmed.ncbi.nlm.nih.gov/41201155/
Integrative analysis of proteomic and mri data reveals protein associations with brain imaging features in Alzheimer's disease - PubMed
This study highlights the critical role of integrating imaging and proteomic data as part of the genotype-to-phenotype roadmap for AD, revealing molecular underpinnings of brain changes and offering…
pubmed.ncbi.nlm.nih.gov
November 15, 2025 at 10:45 PM
3/3
This integrative approach enhances our understanding of AD's molecular mechanisms, paving the way for targeted therapeutic strategies and improved diagnostics. #endalz #brainhealth #neuroscience
📰 pubmed.ncbi.nlm.nih.gov/41201155/
This integrative approach enhances our understanding of AD's molecular mechanisms, paving the way for targeted therapeutic strategies and improved diagnostics. #endalz #brainhealth #neuroscience
📰 pubmed.ncbi.nlm.nih.gov/41201155/
2/3
Key findings include the identification of five proteins - APP, VGF, APOE, SCG3, and NCAN - consistently linked to imaging traits and implicated in neurodegenerative processes.
Key findings include the identification of five proteins - APP, VGF, APOE, SCG3, and NCAN - consistently linked to imaging traits and implicated in neurodegenerative processes.
November 15, 2025 at 10:45 PM
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Key findings include the identification of five proteins - APP, VGF, APOE, SCG3, and NCAN - consistently linked to imaging traits and implicated in neurodegenerative processes.
Key findings include the identification of five proteins - APP, VGF, APOE, SCG3, and NCAN - consistently linked to imaging traits and implicated in neurodegenerative processes.
- Anti-inflammatory effects, reducing harmful cytokines
- Enhanced mitochondrial function and ATP synthesis
- Alleviation of oxidative stress through improved antioxidant defenses
- Neuroprotection for dopaminergic neurons
- Potential to modulate gut microbiota
buff.ly/wjWI01n
- Enhanced mitochondrial function and ATP synthesis
- Alleviation of oxidative stress through improved antioxidant defenses
- Neuroprotection for dopaminergic neurons
- Potential to modulate gut microbiota
buff.ly/wjWI01n
The ketogenic diet in Parkinson's disease: a potential therapeutic strategy - PubMed
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, characterized by debilitating motor and non-motor symptoms. Its complex pathogenesis involves dopaminergic…
buff.ly
November 14, 2025 at 9:45 PM
- Anti-inflammatory effects, reducing harmful cytokines
- Enhanced mitochondrial function and ATP synthesis
- Alleviation of oxidative stress through improved antioxidant defenses
- Neuroprotection for dopaminergic neurons
- Potential to modulate gut microbiota
buff.ly/wjWI01n
- Enhanced mitochondrial function and ATP synthesis
- Alleviation of oxidative stress through improved antioxidant defenses
- Neuroprotection for dopaminergic neurons
- Potential to modulate gut microbiota
buff.ly/wjWI01n
2/3
By shifting energy from glucose to ketone bodies (KBs), such as β-hydroxybutyrate (β-HB), KD shows promise in addressing PD's complex pathogenesis. Key benefits include:
By shifting energy from glucose to ketone bodies (KBs), such as β-hydroxybutyrate (β-HB), KD shows promise in addressing PD's complex pathogenesis. Key benefits include:
November 14, 2025 at 9:45 PM
2/3
By shifting energy from glucose to ketone bodies (KBs), such as β-hydroxybutyrate (β-HB), KD shows promise in addressing PD's complex pathogenesis. Key benefits include:
By shifting energy from glucose to ketone bodies (KBs), such as β-hydroxybutyrate (β-HB), KD shows promise in addressing PD's complex pathogenesis. Key benefits include:
3/3
This study highlights the importance of monitoring brain health in people with diabetes. 🧠
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206345/
This study highlights the importance of monitoring brain health in people with diabetes. 🧠
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206345/
November 13, 2025 at 10:01 PM
3/3
This study highlights the importance of monitoring brain health in people with diabetes. 🧠
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206345/
This study highlights the importance of monitoring brain health in people with diabetes. 🧠
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206345/
2/2 Using advanced imaging, scientists found that both conditions reduce blood vessel density in key brain areas, which could explain why having diabetes raises the risk of developing Alzheimer's.
November 13, 2025 at 10:01 PM
2/2 Using advanced imaging, scientists found that both conditions reduce blood vessel density in key brain areas, which could explain why having diabetes raises the risk of developing Alzheimer's.
3/3
Intervention strategies such as the MIND Diet, Mediterranean diet, physical exercise, and gut microbiota modulation show promise in countering these effects.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41201057/
Intervention strategies such as the MIND Diet, Mediterranean diet, physical exercise, and gut microbiota modulation show promise in countering these effects.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41201057/
November 12, 2025 at 10:15 PM
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Intervention strategies such as the MIND Diet, Mediterranean diet, physical exercise, and gut microbiota modulation show promise in countering these effects.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41201057/
Intervention strategies such as the MIND Diet, Mediterranean diet, physical exercise, and gut microbiota modulation show promise in countering these effects.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41201057/
These factors disrupt synaptic plasticity and neuron survival, influencing memory and attention. Large-scale studies emphasize modifying dietary habits as a prevention strategy.
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November 12, 2025 at 10:15 PM
These factors disrupt synaptic plasticity and neuron survival, influencing memory and attention. Large-scale studies emphasize modifying dietary habits as a prevention strategy.
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Future studies should include biological markers and consider lifestyle factors for a comprehensive evaluation of the gut-brain axis.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206012/
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206012/
Faecal microbiota transplant for Parkinson's disease: promises and future directions - PubMed
There is considerable evidence linking alterations in gut microbiome composition with Parkinson's disease (PD), leading to several recent randomized controlled fecal microbiota transplantation (FMT)…
buff.ly
November 11, 2025 at 10:15 PM
Future studies should include biological markers and consider lifestyle factors for a comprehensive evaluation of the gut-brain axis.
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206012/
Learn more: ht*tps://pubmed.ncbi.nlm.nih.gov/41206012/
Trials report improvements in motor and non-motor symptoms, potentially through enhanced metabolite effects and reduced inflammation. Critical questions remain on donor selection, optimal microbiome screening, and FMT delivery.
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Faecal microbiota transplant for Parkinson's disease: promises and future directions - PubMed
There is considerable evidence linking alterations in gut microbiome composition with Parkinson's disease (PD), leading to several recent randomized controlled fecal microbiota transplantation (FMT)…
buff.ly
November 11, 2025 at 10:15 PM
Trials report improvements in motor and non-motor symptoms, potentially through enhanced metabolite effects and reduced inflammation. Critical questions remain on donor selection, optimal microbiome screening, and FMT delivery.
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