David Posada
@davidposada.bsky.social
An evolutionary biologist working in cancer evolution. Single-cell genomics, bioinformatics, anything phylo (phylogenetics, phylogeography, phylodynamics).
Reposted by David Posada
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £53,500 (Dependent on experience )
Reporting to: Professor Trevor Gra...
jobs.icr.ac.uk
November 13, 2025 at 2:59 PM
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Reposted by David Posada
Become part of a Marie Skłodowska-Curie Doctoral Network a prestigious EU initiative offering world-class research training, international experience, and strong career prospects for early-stage researchers.
It’s more than a PhD:it’s a launchpad for your research career!
Apply now: www.evomg-dn.eu
It’s more than a PhD:it’s a launchpad for your research career!
Apply now: www.evomg-dn.eu
October 16, 2025 at 2:26 PM
Become part of a Marie Skłodowska-Curie Doctoral Network a prestigious EU initiative offering world-class research training, international experience, and strong career prospects for early-stage researchers.
It’s more than a PhD:it’s a launchpad for your research career!
Apply now: www.evomg-dn.eu
It’s more than a PhD:it’s a launchpad for your research career!
Apply now: www.evomg-dn.eu
Reposted by David Posada
We are hiring a postdoc to profile the evolvability of tumors in longitudinal samples from three clinical trials as part of the ARPA-H ADAPT program. This is essentially an evolutionary bioinformatics position. If you are interested, please apply here ASAP apply.interfolio.com/172521
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 9:52 PM
We are hiring a postdoc to profile the evolvability of tumors in longitudinal samples from three clinical trials as part of the ARPA-H ADAPT program. This is essentially an evolutionary bioinformatics position. If you are interested, please apply here ASAP apply.interfolio.com/172521
Reposted by David Posada
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
October 14, 2025 at 8:21 PM
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Reposted by David Posada
The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
Carboplatin adaptive therapy improves treatment efficacy without increasing daily dose due to reduced fitness of drug-resistant populations, which can be tracked using cfDNA and could direct adaptive ...
aacrjournals.org
October 14, 2025 at 8:26 PM
The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...
Reposted by David Posada
📢 EvoMG-DN PhD applications are now open!
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
October 7, 2025 at 8:28 AM
📢 EvoMG-DN PhD applications are now open!
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu
📅 Apply by 30 November 2025
#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers
Reposted by David Posada
And the last session of the meeting was Session 5: Cancer.
The first speaker was David Posada ( @davidposada.bsky.social ), from the Universidade de Vigo and @cinbio.bsky.social, who showed us how somatic phylogenetics can provide fundamental insights into the evolutionary dynamics of cancer.
The first speaker was David Posada ( @davidposada.bsky.social ), from the Universidade de Vigo and @cinbio.bsky.social, who showed us how somatic phylogenetics can provide fundamental insights into the evolutionary dynamics of cancer.
October 12, 2025 at 4:04 PM
And the last session of the meeting was Session 5: Cancer.
The first speaker was David Posada ( @davidposada.bsky.social ), from the Universidade de Vigo and @cinbio.bsky.social, who showed us how somatic phylogenetics can provide fundamental insights into the evolutionary dynamics of cancer.
The first speaker was David Posada ( @davidposada.bsky.social ), from the Universidade de Vigo and @cinbio.bsky.social, who showed us how somatic phylogenetics can provide fundamental insights into the evolutionary dynamics of cancer.
📢 PhD position at the Posada Lab!
🚀 Join us at the University of Vigo to track how tumor cells evolve, adapt, and survive using cutting-edge single-cell DNA/RNA tech. 4-year PhD, €134K total funding—apply by Nov 3, 2025.
👉 dposada.webs.uvigo.es/2025/10/07/p...
🚀 Join us at the University of Vigo to track how tumor cells evolve, adapt, and survive using cutting-edge single-cell DNA/RNA tech. 4-year PhD, €134K total funding—apply by Nov 3, 2025.
👉 dposada.webs.uvigo.es/2025/10/07/p...
SRHI - Axudas FPI
sede.uvigo.gal
October 7, 2025 at 9:35 AM
📢 PhD position at the Posada Lab!
🚀 Join us at the University of Vigo to track how tumor cells evolve, adapt, and survive using cutting-edge single-cell DNA/RNA tech. 4-year PhD, €134K total funding—apply by Nov 3, 2025.
👉 dposada.webs.uvigo.es/2025/10/07/p...
🚀 Join us at the University of Vigo to track how tumor cells evolve, adapt, and survive using cutting-edge single-cell DNA/RNA tech. 4-year PhD, €134K total funding—apply by Nov 3, 2025.
👉 dposada.webs.uvigo.es/2025/10/07/p...
🚨Our new study in Cellular Oncology🚨 shows high CTC genomic diversity & BCL9L mutations predict worse survival in metastatic colorectal cancer—supporting liquid biopsy for prognosis. 🎯🧬
Thanks to all co-authors!
doi.org/10.1007/s134...
Thanks to all co-authors!
doi.org/10.1007/s134...
Genomic diversity and BCL9L mutational status in circulating tumor cells predict overall survival in metastatic colorectal cancer - Cellular Oncology
Background Metastatic colorectal cancer (mCRC) remains a major cause of cancer-related mortality, but few noninvasive biomarkers exist to track disease progression or inform treatment strategies. Circulating tumor cells (CTCs) offer a minimally invasive source of tumor material, yet the prognostic significance of their genomic diversity remains unclear. Methods We conducted whole-exome sequencing of CTC pools from 29 mCRC patients to characterize their mutational landscape and assess associations with overall survival. Results Our analysis revealed substantial variation in mutational burden among patients, with all CTC pools harboring non-silent mutations in key CRC driver genes. Higher genomic diversity in CTC pools was significantly associated with reduced overall survival. Additionally, non-silent mutations in BCL9L emerged as a strong predictor of patient survival. Conclusion Genomic diversity and BCL9L mutational status in CTC pools emerged as strong predictors of survival in mCRC, underscoring the potential of CTC genomic profiling as a minimally invasive and clinically relevant prognostic tool in mCRC.
doi.org
October 7, 2025 at 6:26 AM
🚨Our new study in Cellular Oncology🚨 shows high CTC genomic diversity & BCL9L mutations predict worse survival in metastatic colorectal cancer—supporting liquid biopsy for prognosis. 🎯🧬
Thanks to all co-authors!
doi.org/10.1007/s134...
Thanks to all co-authors!
doi.org/10.1007/s134...
It was a pleasure to join @aecc_es in Pontevedra for the World Cancer Research Day — talking with and listening to patients about the power of science and hope. Without research, there’s no cure. 💚 #ScienceIsHope"
September 25, 2025 at 7:16 AM
It was a pleasure to join @aecc_es in Pontevedra for the World Cancer Research Day — talking with and listening to patients about the power of science and hope. Without research, there’s no cure. 💚 #ScienceIsHope"
Reposted by David Posada
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
🚀 Excited to share our latest collaboration with Ewa Szczurek’s lab (@ewaszczurek.bsky.social) et al. in Genome Biology!
🧬 DelSIEVE: single-cell phylogeny from SNVs & indels 🧬
👉 rdcu.be/eCnL3
Big thanks to Senbai and Ewa for leading this project, and to all collaborators who made it possible! 🙌
🧬 DelSIEVE: single-cell phylogeny from SNVs & indels 🧬
👉 rdcu.be/eCnL3
Big thanks to Senbai and Ewa for leading this project, and to all collaborators who made it possible! 🙌
DelSIEVE: cell phylogeny modeling of single nucleotide variants and deletions from single-cell DNA sequencing data
rdcu.be
September 8, 2025 at 7:17 AM
🚀 Excited to share our latest collaboration with Ewa Szczurek’s lab (@ewaszczurek.bsky.social) et al. in Genome Biology!
🧬 DelSIEVE: single-cell phylogeny from SNVs & indels 🧬
👉 rdcu.be/eCnL3
Big thanks to Senbai and Ewa for leading this project, and to all collaborators who made it possible! 🙌
🧬 DelSIEVE: single-cell phylogeny from SNVs & indels 🧬
👉 rdcu.be/eCnL3
Big thanks to Senbai and Ewa for leading this project, and to all collaborators who made it possible! 🙌
🎉 Last week, Nair successfully defended her Ph.D thesis on the genomic heterogeneity of circulating tumor cells and their role in metastasis! Her research sheds light on how cancer spreads. Huge congratulations to Nair on this outstanding achievement! 👏🧬
August 4, 2025 at 7:30 AM
🎉 Last week, Nair successfully defended her Ph.D thesis on the genomic heterogeneity of circulating tumor cells and their role in metastasis! Her research sheds light on how cancer spreads. Huge congratulations to Nair on this outstanding achievement! 👏🧬
Intraline genomic heterogeneity of the TNBC MDA-MB-231-luc-GFP cell line www.csbj.org/article/S200...
Intraline genomic heterogeneity of the triple-negative breast cancer MDA-MB-231-luc-GFP cell line
Cancer cell lines are valuable models for studying tumor biology, yet their genomic
evolution during culture can compromise experimental reproducibility. We conducted
a detailed genomic analysis of th...
www.csbj.org
July 3, 2025 at 10:03 AM
Intraline genomic heterogeneity of the TNBC MDA-MB-231-luc-GFP cell line www.csbj.org/article/S200...
🦠 New paper out in Communications Medicine!
🌍🔬 We tracked the global spread and introductions of SARS-CoV-2 variants Alpha, Delta, and Omicron BA.1 into Spain.
Great collaboration with @lemeylab.bsky.social @guybaele.bsky.social @msuchard.bsky.social and others
📖 rdcu.be/eoG7x
🌍🔬 We tracked the global spread and introductions of SARS-CoV-2 variants Alpha, Delta, and Omicron BA.1 into Spain.
Great collaboration with @lemeylab.bsky.social @guybaele.bsky.social @msuchard.bsky.social and others
📖 rdcu.be/eoG7x
International importance and spread of SARS-CoV-2 variants Alpha, Delta, and Omicron BA.1 into Spain
Communications Medicine - Gallego García et al. trace the entry and spread of SARS-CoV-2 Alpha, Delta, and Omicron BA.1 into Spain. The main route of entry is via France, the United Kingdom,...
rdcu.be
June 2, 2025 at 6:05 AM
🦠 New paper out in Communications Medicine!
🌍🔬 We tracked the global spread and introductions of SARS-CoV-2 variants Alpha, Delta, and Omicron BA.1 into Spain.
Great collaboration with @lemeylab.bsky.social @guybaele.bsky.social @msuchard.bsky.social and others
📖 rdcu.be/eoG7x
🌍🔬 We tracked the global spread and introductions of SARS-CoV-2 variants Alpha, Delta, and Omicron BA.1 into Spain.
Great collaboration with @lemeylab.bsky.social @guybaele.bsky.social @msuchard.bsky.social and others
📖 rdcu.be/eoG7x
🚨 New paper out in Cell Reports Methods! 🧬✨
After a long, long journey, we're thrilled to share our deep-dive into six single-cell whole-genome amplification (scWGA) methods.
🔍 TL;DR: no one-size-fits-all
Huge congrats to the whole team!
📝 doi.org/10.1016/j.cr...
After a long, long journey, we're thrilled to share our deep-dive into six single-cell whole-genome amplification (scWGA) methods.
🔍 TL;DR: no one-size-fits-all
Huge congrats to the whole team!
📝 doi.org/10.1016/j.cr...
doi.org
April 24, 2025 at 12:25 PM
🚨 New paper out in Cell Reports Methods! 🧬✨
After a long, long journey, we're thrilled to share our deep-dive into six single-cell whole-genome amplification (scWGA) methods.
🔍 TL;DR: no one-size-fits-all
Huge congrats to the whole team!
📝 doi.org/10.1016/j.cr...
After a long, long journey, we're thrilled to share our deep-dive into six single-cell whole-genome amplification (scWGA) methods.
🔍 TL;DR: no one-size-fits-all
Huge congrats to the whole team!
📝 doi.org/10.1016/j.cr...
Reposted by David Posada
Steve Kerr wore a Harvard basketball shirt after the Warriors’ win tonight: “Yes, this is me supporting Harvard. Way to go. Way to stand up to the bully.”
April 16, 2025 at 7:09 AM
Steve Kerr wore a Harvard basketball shirt after the Warriors’ win tonight: “Yes, this is me supporting Harvard. Way to go. Way to stand up to the bully.”
Reposted by David Posada
"Many, and perhaps most, members of our academic community do not understand [the benefits of publishing] in society-based journals ... compared with for-profit journals from companies like Springer Nature, Frontiers, Wiley, and Elsevier." 🧪
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
academic.oup.com
March 9, 2025 at 6:50 PM
"Many, and perhaps most, members of our academic community do not understand [the benefits of publishing] in society-based journals ... compared with for-profit journals from companies like Springer Nature, Frontiers, Wiley, and Elsevier." 🧪
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
Reposted by David Posada
Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social
Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.
Brilliant & inspiring faculty! bit.ly/40nLdDD
Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.
Brilliant & inspiring faculty! bit.ly/40nLdDD
March 7, 2025 at 1:58 PM
Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social
Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.
Brilliant & inspiring faculty! bit.ly/40nLdDD
Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.
Brilliant & inspiring faculty! bit.ly/40nLdDD
Reposted by David Posada
We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
February 19, 2025 at 6:08 PM
We have two open positions for #computationalbiologists to work on:
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
1. Early cancer initiation following our work in #NatureCancer (Ref 5028)
2. Response to cancer immunotherapy following our work in #CancerCell (Ref 5073)
To apply use the provided reference numbers: www.qmul.ac.uk/jobs/vacanci...
🎓 Como School on Cancer Evolution (CSCE 2025) for cutting-edge discussions on cancer biology, computational sciences, AI, and more! 🧬🌟 May 27-30, 2025, Villa del Grumello, Como, Italy 🇮🇹. Present your research & network with pioneers in the field. Register at: csce.lakecomoschool.org/registration/
Registration - Como School on Cancer Evolution 27-30 May 2025
Registration Registration: 400 EUR (includes social dinner) On-premise, per-day registration: 120 EUR (social dinner not included) All fees include VAT. How to register Please fill in the form below ...
csce.lakecomoschool.org
February 14, 2025 at 7:34 AM
🎓 Como School on Cancer Evolution (CSCE 2025) for cutting-edge discussions on cancer biology, computational sciences, AI, and more! 🧬🌟 May 27-30, 2025, Villa del Grumello, Como, Italy 🇮🇹. Present your research & network with pioneers in the field. Register at: csce.lakecomoschool.org/registration/
📢 Exciting news! Journal of Molecular Evolution meeting in Madrid, Aug 25-28, 2025! 🌍✨
✅ Free registration
🎙️ Talks + poster sessions
📅 Special AlphaFold symposium on Aug 28
🔗 Details & registration: www.mncn.csic.es/es/investiga...
Register by March 1, 2025 to secure your spot! 🧬
✅ Free registration
🎙️ Talks + poster sessions
📅 Special AlphaFold symposium on Aug 28
🔗 Details & registration: www.mncn.csic.es/es/investiga...
Register by March 1, 2025 to secure your spot! 🧬
Journal of Molecular Evolution: A European Meeting | Museo Nacional de Ciencias Naturales
www.mncn.csic.es
February 11, 2025 at 7:37 AM
📢 Exciting news! Journal of Molecular Evolution meeting in Madrid, Aug 25-28, 2025! 🌍✨
✅ Free registration
🎙️ Talks + poster sessions
📅 Special AlphaFold symposium on Aug 28
🔗 Details & registration: www.mncn.csic.es/es/investiga...
Register by March 1, 2025 to secure your spot! 🧬
✅ Free registration
🎙️ Talks + poster sessions
📅 Special AlphaFold symposium on Aug 28
🔗 Details & registration: www.mncn.csic.es/es/investiga...
Register by March 1, 2025 to secure your spot! 🧬
The Galician Government has announced new postdoctoral fellowships (3+3 year contract). However, they are exclusively available to PhD students from Galician universities. If you are interested, please get in touch with me as soon as possible.
More information at: www.edu.xunta.gal/portal/node/...
More information at: www.edu.xunta.gal/portal/node/...
Axudas de apoio á etapa de formación posdoutoral nas universidades do SUG, nos organismos públicos de investigación de Galicia e noutras entidades do Sistema de I+D+i galego, convocatoria para o ano 2...
Programa: Axudas de apoio á etapa de formación posdoutoral Data de publicación DOG: 31.01.2025 Código do procedemento: ED481B e IN606B Prazo de presentación de solicitudes: ata 28.02.2025 Cal é o obxe...
www.edu.xunta.gal
February 5, 2025 at 7:57 AM
The Galician Government has announced new postdoctoral fellowships (3+3 year contract). However, they are exclusively available to PhD students from Galician universities. If you are interested, please get in touch with me as soon as possible.
More information at: www.edu.xunta.gal/portal/node/...
More information at: www.edu.xunta.gal/portal/node/...
👋 Hello Bluesky! So glad to be here. I just deactivated my X account and look forward to connecting with you all. Happy 2025! 🎉
January 2, 2025 at 9:46 AM
👋 Hello Bluesky! So glad to be here. I just deactivated my X account and look forward to connecting with you all. Happy 2025! 🎉