David Nie
@davidnie.bsky.social
🇨🇦 #ChemBio Postdoc | 🔬 #SmallMolecules & Big Questions | Untangling puzzles one experiment at a time 🧬
Reposted by David Nie
Just published in Nature Reviews Chemistry - the Target 2035 roadmap for chemical probes for all! lnkd.in/gGqMUTVq
July 23, 2025 at 5:23 PM
Just published in Nature Reviews Chemistry - the Target 2035 roadmap for chemical probes for all! lnkd.in/gGqMUTVq
Reposted by David Nie
Next steps for targeted protein degradation: Cell Chemical Biology www.cell.com/cell-chemica... #TPD #PROTACs
Next steps for targeted protein degradation
Modalities and applications of targeted protein degradation (TPD) have rapidly expanded
the therapeutic possibilities of proximity induced pharmacology. Here, Krone et al.
spotlight three focal points...
www.cell.com
February 22, 2025 at 6:29 PM
Next steps for targeted protein degradation: Cell Chemical Biology www.cell.com/cell-chemica... #TPD #PROTACs
When serendipitous discoveries converge!
A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein
degradation
www.nature.com/articles/s41...
degradation
www.nature.com/articles/s41...
Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
www.nature.com
February 21, 2025 at 8:45 PM
When serendipitous discoveries converge!