David Clinkard
@davidclinkardmd.bsky.social
Consultant Anesthesiologist and Pain Medicine- FRCPC x 2, M.Sc, MD. How can we improve health to reduce pain? Swimmer, biker and sorta runner, love my dog.
Reposted by David Clinkard
Heart failure paradoxically involves both cell growth and death. Imaging single cell dynamics, we found that when stressed, individual cardiomyocytes commit early to either grow or die. #MicroscopyMonday
December 30, 2024 at 11:38 PM
Heart failure paradoxically involves both cell growth and death. Imaging single cell dynamics, we found that when stressed, individual cardiomyocytes commit early to either grow or die. #MicroscopyMonday
Reposted by David Clinkard
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 23, 2024 at 4:04 PM
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Super interesting study that suggests exogenous ketones decrease FFA utilization in normal hearts
SGLT2 inhibitors exert cardioprotective effects in heart failure but the role of ketone oxidation has been debated.
Goedeke et al. used sophisticated tracer experiments to evaluate the effects of SGLT inhibitors on cardiac metabolism in models: https://www.jci.org/articles/view/176708
Goedeke et al. used sophisticated tracer experiments to evaluate the effects of SGLT inhibitors on cardiac metabolism in models: https://www.jci.org/articles/view/176708
December 18, 2024 at 6:16 PM
Super interesting study that suggests exogenous ketones decrease FFA utilization in normal hearts
Reposted by David Clinkard
'Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland–innervating neurons.'
Just a moment...
www.science.org
July 21, 2023 at 1:19 AM
'Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland–innervating neurons.'
I backpacked through Syria in 2008 for 2 months. Was a beautiful country with the most welcoming people of anywhere I have traveled before or since. I hope this regime change allows peace for a population decimated by war and that I (selfishly) can return to re-experience the amazing hospitality.
December 8, 2024 at 2:54 PM
I backpacked through Syria in 2008 for 2 months. Was a beautiful country with the most welcoming people of anywhere I have traveled before or since. I hope this regime change allows peace for a population decimated by war and that I (selfishly) can return to re-experience the amazing hospitality.
So glad I never have to deal with this here in Canada
I filed a complaint with the state medical board, appealed and won the denial, and made this guy famous.
Physicians working to deny healthcare on behalf of greedy insurance companies deserve to be held accountable for harming others and making our jobs harder.
www.propublica.org/article/malp...
Physicians working to deny healthcare on behalf of greedy insurance companies deserve to be held accountable for harming others and making our jobs harder.
www.propublica.org/article/malp...
Doctors With Histories of Big Malpractice Settlements Now Work for Insurers
Doctors working for health insurers can rule on 10,000 or more requests for care a year. At least a dozen were hired by major insurance companies after being disciplined by state medical boards or mak...
www.propublica.org
November 24, 2024 at 7:22 PM
So glad I never have to deal with this here in Canada
Happy to finally publish my comment in CJA - are we really thinking about the long term effects of anti-inflammatories preoperatively?? link.springer.com/article/10.1...
The role of acute inflammation in pain resolution: is it time to rethink the use of routine anti-inflammatories in surgical practice? - Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Canadian Journal of Anesthesia/Journal canadien d'anesthésie -
link.springer.com
November 22, 2024 at 10:38 AM
Happy to finally publish my comment in CJA - are we really thinking about the long term effects of anti-inflammatories preoperatively?? link.springer.com/article/10.1...