David Mai
@davemai.bsky.social
postdoc @fredhutch.org @uwproteindesign.bsky.social | made via @hprscholars.bsky.social + penn + berkeley
amazing tech dev - it wasn't that long ago that i was testing singular and a few multiplexed KOs in a non-pooled comparison format
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 7:36 PM
amazing tech dev - it wasn't that long ago that i was testing singular and a few multiplexed KOs in a non-pooled comparison format
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
really cool gene expression control method using a drug-controlled stem loop structure!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A portable poison exon for small-molecule control of mammalian gene expression - Nature Methods
This work introduces Cyclone, an acyclovir-controlled cassette that enables regulation of both transgene and endogenous gene expression with minimal background activity.
www.nature.com
November 3, 2025 at 7:35 PM
really cool gene expression control method using a drug-controlled stem loop structure!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Mai
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
September 17, 2025 at 3:03 PM
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
phagocytic T cells!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Expanding the cytokine receptor alphabet reprograms T cells into diverse states - Nature
Orthogonal chimeric receptors containing intracellular domains for IL-4R, IL-20R, IL-22R and GCSFR reprogram T cells to promote distinct natural and synthetic cell states with functional and therapeut...
www.nature.com
August 18, 2025 at 5:02 PM
phagocytic T cells!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Mai
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
August 11, 2025 at 6:54 PM
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
Reposted by David Mai
Hello Seattle! We are excited to present the Science for All rally next Sunday, 5/18, from 9-11am on the Seattle Waterfront! Please sign up via our Mobilize link (www.mobilize.us/mobilize/eve...) if you plan on attending. Hope to see you there!
May 13, 2025 at 12:55 AM
Hello Seattle! We are excited to present the Science for All rally next Sunday, 5/18, from 9-11am on the Seattle Waterfront! Please sign up via our Mobilize link (www.mobilize.us/mobilize/eve...) if you plan on attending. Hope to see you there!
Reposted by David Mai
Two great talks lined up for the final Friday Afternoon Seminars of the season!
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
May 16, 2025 at 9:21 PM
Two great talks lined up for the final Friday Afternoon Seminars of the season!
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
Amazing and inspiring @urnov.bsky.social!
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 15, 2025 at 6:57 PM
Amazing and inspiring @urnov.bsky.social!
Reposted by David Mai
Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction
Two evolutionary strategies allow the antiviral protein MxA to evolve simultaneous super-restriction against multiple viruses.
www.science.org
May 5, 2025 at 9:48 PM
Really excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
www.science.org/doi/10.1126/...
Rechel is now back in medical school training to become a kickass physician-scientist
Reposted by David Mai
Great news! 4 postdocs in Basic Sciences @FredHutch.bsky.social will receive WRF fellowships. Congrats Allie Cheney in the Talbot Lab, @davemai.bsky.social in the @sanjaysrivatsan.bsky.social Lab, Sara Sunshine in the @jbloomlab.bsky.social, and Alina Lorant in the Koch Lab!
Washington Research Foundation awards 12 three-year postdoctoral fellowships
/PRNewswire-PRWeb/ -- Washington Research Foundation (WRF) has awarded three-year postdoctoral fellowships to 12 early-career researchers to enable them to...
buff.ly
December 19, 2024 at 7:49 PM
Great news! 4 postdocs in Basic Sciences @FredHutch.bsky.social will receive WRF fellowships. Congrats Allie Cheney in the Talbot Lab, @davemai.bsky.social in the @sanjaysrivatsan.bsky.social Lab, Sara Sunshine in the @jbloomlab.bsky.social, and Alina Lorant in the Koch Lab!
it's good to be back philly
November 24, 2024 at 5:10 PM
it's good to be back philly