Fred Hutch Basic Sciences Division
@basicsci.fredhutch.org
Making Foundational Discoveries @fredhutch.org
fredhutch.org/basicsciences
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2025 was an exceptional year for the Basic Sciences Division. We celebrated @fredhutch.org’s 50th anniversary, faculty, trainees, and staff receiving numerous awards, the retirements of Drs. Jon Cooper and Michael Emerman, and so much more.
Get the highlights in our annual report: buff.ly/xQ8hsUM
Get the highlights in our annual report: buff.ly/xQ8hsUM
Reposted by Fred Hutch Basic Sciences Division
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
2025 was an exceptional year for the Basic Sciences Division. We celebrated @fredhutch.org’s 50th anniversary, faculty, trainees, and staff receiving numerous awards, the retirements of Drs. Jon Cooper and Michael Emerman, and so much more.
Get the highlights in our annual report: buff.ly/xQ8hsUM
Get the highlights in our annual report: buff.ly/xQ8hsUM
December 12, 2025 at 7:36 PM
2025 was an exceptional year for the Basic Sciences Division. We celebrated @fredhutch.org’s 50th anniversary, faculty, trainees, and staff receiving numerous awards, the retirements of Drs. Jon Cooper and Michael Emerman, and so much more.
Get the highlights in our annual report: buff.ly/xQ8hsUM
Get the highlights in our annual report: buff.ly/xQ8hsUM
Reposted by Fred Hutch Basic Sciences Division
Last seminar of 2025: Dr. @sanjaysrivatsan.bsky.social from @fredhutch.org discussed capsule-based genome sequencing and lineage tracing. Thank you to everyone who joined us in person and via Zoom. Recording available on our YouTube channel: youtu.be/ykS0q7Pl3xo?...
@jlmcfalinefigueroa.bsky.social
@jlmcfalinefigueroa.bsky.social
December 11, 2025 at 2:04 PM
Last seminar of 2025: Dr. @sanjaysrivatsan.bsky.social from @fredhutch.org discussed capsule-based genome sequencing and lineage tracing. Thank you to everyone who joined us in person and via Zoom. Recording available on our YouTube channel: youtu.be/ykS0q7Pl3xo?...
@jlmcfalinefigueroa.bsky.social
@jlmcfalinefigueroa.bsky.social
Today we celebrated the retirement of research administration manager Katrina Akioka after 13 years @fredhutch.org. She leaves behind a legacy of service to Fred Hutch, the division, and the many faculty and labs she supported over the years. We wish her all the best in retirement.
December 9, 2025 at 1:12 AM
Today we celebrated the retirement of research administration manager Katrina Akioka after 13 years @fredhutch.org. She leaves behind a legacy of service to Fred Hutch, the division, and the many faculty and labs she supported over the years. We wish her all the best in retirement.
Reposted by Fred Hutch Basic Sciences Division
Happening TODAY - Timothy Yu’s ( @timyu.bsky.social ) dissertation defense!
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
December 8, 2025 at 4:00 PM
Happening TODAY - Timothy Yu’s ( @timyu.bsky.social ) dissertation defense!
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
It’s almost the best part of the week: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Changkun Hu in the @suebiggins.bsky.social Lab and Haolong Li from the Human Biology Division. For all our @FredHutch.org colleagues, join us in Pelton at 4PM for two great talks!
Can’t wait to learn about the latest research from Changkun Hu in the @suebiggins.bsky.social Lab and Haolong Li from the Human Biology Division. For all our @FredHutch.org colleagues, join us in Pelton at 4PM for two great talks!
December 5, 2025 at 10:29 PM
It’s almost the best part of the week: Friday Afternoon Seminars!
Can’t wait to learn about the latest research from Changkun Hu in the @suebiggins.bsky.social Lab and Haolong Li from the Human Biology Division. For all our @FredHutch.org colleagues, join us in Pelton at 4PM for two great talks!
Can’t wait to learn about the latest research from Changkun Hu in the @suebiggins.bsky.social Lab and Haolong Li from the Human Biology Division. For all our @FredHutch.org colleagues, join us in Pelton at 4PM for two great talks!
Reposted by Fred Hutch Basic Sciences Division
Very proud of our lab manager, Aida de la Cruz, for winning the Nancy Hutchinson mentoring award (www.fredhutch.org/en/education...) based on her mentees' nominations.
@fredhutch.org @basicsci.fredhutch.org
Internal news: centernet.fredhutch.org/n/2025/12/sp...
@fredhutch.org @basicsci.fredhutch.org
Internal news: centernet.fredhutch.org/n/2025/12/sp...
December 5, 2025 at 7:43 PM
Very proud of our lab manager, Aida de la Cruz, for winning the Nancy Hutchinson mentoring award (www.fredhutch.org/en/education...) based on her mentees' nominations.
@fredhutch.org @basicsci.fredhutch.org
Internal news: centernet.fredhutch.org/n/2025/12/sp...
@fredhutch.org @basicsci.fredhutch.org
Internal news: centernet.fredhutch.org/n/2025/12/sp...
Congratulations to Aida de la Cruz, lab manager in the @harmitmalik.bsky.social Lab, on receiving the Hutchison Award! The award, presented by @fredhutch.org SPAC and named for Dr. Nancy Hutchison, recognizes phenomenal mentorship. It also comes with an awesome personalized bobblehead.
December 5, 2025 at 9:30 PM
Congratulations to Aida de la Cruz, lab manager in the @harmitmalik.bsky.social Lab, on receiving the Hutchison Award! The award, presented by @fredhutch.org SPAC and named for Dr. Nancy Hutchison, recognizes phenomenal mentorship. It also comes with an awesome personalized bobblehead.
Reposted by Fred Hutch Basic Sciences Division
See you next week for Timothy Yu’s (@timyu.bsky.social ) dissertation defense!
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
December 1, 2025 at 10:00 PM
See you next week for Timothy Yu’s (@timyu.bsky.social ) dissertation defense!
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
Title: Epistasis and pleiotropy in viral protein evolution
Lab: Bloom Lab, FH
When: Monday, December 8, 2 p.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building) & Zoom (email mcb@uw.edu for link)
We have two great speakers lined up for Friday Afternoon Seminars!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Gardenia Sanchez from the @yarimura.bsky.social and Saurabh Verma from Human Biology’s Nelson Lab share their latest discoveries!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Gardenia Sanchez from the @yarimura.bsky.social and Saurabh Verma from Human Biology’s Nelson Lab share their latest discoveries!
November 21, 2025 at 9:53 PM
We have two great speakers lined up for Friday Afternoon Seminars!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Gardenia Sanchez from the @yarimura.bsky.social and Saurabh Verma from Human Biology’s Nelson Lab share their latest discoveries!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Gardenia Sanchez from the @yarimura.bsky.social and Saurabh Verma from Human Biology’s Nelson Lab share their latest discoveries!
We’re excited to have Edgar Fernandes from the Talbot Lab and Supriya Amonkar from Human Biology’s Galloway Lab sharing their latest research at Friday Afternoon Seminars. For all our @FredHutch.org colleagues, don’t miss two fantastic talks today at 4:00!
November 14, 2025 at 10:10 PM
We’re excited to have Edgar Fernandes from the Talbot Lab and Supriya Amonkar from Human Biology’s Galloway Lab sharing their latest research at Friday Afternoon Seminars. For all our @FredHutch.org colleagues, don’t miss two fantastic talks today at 4:00!
Excited for two great speakers at Friday Afternoon Seminars!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
November 7, 2025 at 9:48 PM
Excited for two great speakers at Friday Afternoon Seminars!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
Reposted by Fred Hutch Basic Sciences Division
Join us for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
October 31, 2025 at 5:00 PM
Join us for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Reposted by Fred Hutch Basic Sciences Division
Congrats to Steven Henikoff, PhD, of @basicsci.fredhutch.org on receiving the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research! @brandeisuniversity.bsky.social recognized Henikoff with this prestigious award for his innovative studies on gene expression.
Brandeis University honors Fred Hutch molecular biologist
Dr. Steven Henikoff, a molecular biologist at Fred Hutch Cancer Center, has won the prestigious Rosenstiel Award for Distinguished Work in Basic Medical Research from Brandeis University recognizing h...
www.fredhutch.org
October 31, 2025 at 12:37 PM
Congrats to Steven Henikoff, PhD, of @basicsci.fredhutch.org on receiving the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research! @brandeisuniversity.bsky.social recognized Henikoff with this prestigious award for his innovative studies on gene expression.
Today we celebrated Dr. Steve Henikoff receiving the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. Dr. Henikoff will formally receive the award and present a lecture on his work next April @brandeisuniversity.bsky.social.
www.brandeis.edu/stories/2025...
www.brandeis.edu/stories/2025...
October 29, 2025 at 8:21 PM
Today we celebrated Dr. Steve Henikoff receiving the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. Dr. Henikoff will formally receive the award and present a lecture on his work next April @brandeisuniversity.bsky.social.
www.brandeis.edu/stories/2025...
www.brandeis.edu/stories/2025...
Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research.
Professor Steven Henikoff receives 55th Rosenstiel Award for research on genome organization and gene expression
October 29, 2025
www.brandeis.edu
October 29, 2025 at 7:06 PM
Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research.
Reposted by Fred Hutch Basic Sciences Division
@jhigginswriter.bsky.social wrote an article about my lab and our frog 🐸 at the Hutch! Thank you!
Dr. @yarimura.bsky.social brings frogs back to Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. bit.ly/3J8S5Ae
Frogs help Fred Hutch find the shape of small things
Frogs have made significant contributions to Fred Hutch science over the years as a model organism that shares much of our biology, but they've been absent from the menagerie for about two decades. Dr...
bit.ly
October 29, 2025 at 6:29 AM
@jhigginswriter.bsky.social wrote an article about my lab and our frog 🐸 at the Hutch! Thank you!
"Foundation models for 3D genome architecture and tandem mass spectra"
We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!
We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!
October 28, 2025 at 5:19 PM
"Foundation models for 3D genome architecture and tandem mass spectra"
We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!
We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!
Reposted by Fred Hutch Basic Sciences Division
When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.
October 27, 2025 at 4:53 PM
When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.
Reposted by Fred Hutch Basic Sciences Division
Dr. @yarimura.bsky.social brings frogs back to Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. bit.ly/3J8S5Ae
Frogs help Fred Hutch find the shape of small things
Frogs have made significant contributions to Fred Hutch science over the years as a model organism that shares much of our biology, but they've been absent from the menagerie for about two decades. Dr...
bit.ly
October 27, 2025 at 9:33 PM
Dr. @yarimura.bsky.social brings frogs back to Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. bit.ly/3J8S5Ae
Reposted by Fred Hutch Basic Sciences Division
More pictures of the brilliance that is (lab manager) Aida de la Cruz with her creation.
October 25, 2025 at 2:41 AM
More pictures of the brilliance that is (lab manager) Aida de la Cruz with her creation.
So many phenomenal pumpkins at this year’s carving contest!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
October 25, 2025 at 12:31 AM
So many phenomenal pumpkins at this year’s carving contest!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
The 2025 Pumpkin Carving Contest Kicks off at 4pm today! Can’t wait to see everyone and their amazing pumpkins!
October 24, 2025 at 6:08 PM
The 2025 Pumpkin Carving Contest Kicks off at 4pm today! Can’t wait to see everyone and their amazing pumpkins!
Reposted by Fred Hutch Basic Sciences Division
In a study published in @science.org, Fred Hutch immunologist Meghan Koch, PhD, describes how breastmilk helps newborn mice develop immune tolerance to gut microbes and new foods, revealing a key mechanism that kicks in during the first week of life. https://bit.ly/4ogmQ53
October 13, 2025 at 3:54 PM
In a study published in @science.org, Fred Hutch immunologist Meghan Koch, PhD, describes how breastmilk helps newborn mice develop immune tolerance to gut microbes and new foods, revealing a key mechanism that kicks in during the first week of life. https://bit.ly/4ogmQ53
It's a Basic Sciences double feature for Friday Afternoon Seminars! Excited to learn about the latest discoveries from Xiaohui Ju in the @jbloomlab.bsky.social and Matthew Chan in the @rasilab.bsky.social and @melodygcampbell.bsky.social Lab. See everyone at 4pm in Pelton for two great talks!
October 17, 2025 at 9:43 PM
It's a Basic Sciences double feature for Friday Afternoon Seminars! Excited to learn about the latest discoveries from Xiaohui Ju in the @jbloomlab.bsky.social and Matthew Chan in the @rasilab.bsky.social and @melodygcampbell.bsky.social Lab. See everyone at 4pm in Pelton for two great talks!