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Fred Hutch Basic Sciences Division
@basicsci.fredhutch.org
940 followers 690 following 81 posts
Making Foundational Discoveries @fredhutch.org
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Excited for two great speakers at Friday Afternoon Seminars!

For all our @FredHutch.org colleagues , join us at 4:00 in Pelton to hear Alina Lorant from the Koch Lab and Naomi Yamamoto from Human Biology’s Kugel Lab share their latest research!
Friday Afternoon Seminars (FAS), this Friday 11/7 at 4pm in Pelton. Alina Lorant, Koch Lab Microbiota educate early-life myeloid cells to promote tolerance in the intestine Naomi Yamamoto, Kugel Lab HMGA2 regulates fibroblast polarization and immunosuppression in pancreatic cancer
November 7, 2025 at 9:48 PM
basicsci.fredhutch.org
Today we celebrated Dr. Steve Henikoff receiving the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. Dr. Henikoff will formally receive the award and present a lecture on his work next April @brandeisuniversity.bsky.social.

www.brandeis.edu/stories/2025...
October 29, 2025 at 8:21 PM
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"Foundation models for 3D genome architecture and tandem mass spectra"

We’re excited to have @wnoble.bsky.social joining us from @uwgenome.bsky.social to share his latest research at today’s Current Biology Seminar! For all our @fredhutch.org colleagues, don’t miss a great talk at noon in Pelton!
William Stafford Noble, PhD Professor Department of Genome Sciences University of Washington Title: "Foundation models for 3D genome architecture and tandem mass spectra" 12:00pm on Tuesday, October 28, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
October 28, 2025 at 5:19 PM
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Thanks to everyone for such a great event and thanks as always to our emcee Luna!
October 25, 2025 at 12:38 AM
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Even more exceptional pumpkins:
October 25, 2025 at 12:36 AM
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Here are some more of the amazing pumpkins that were on display:
October 25, 2025 at 12:33 AM
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So many phenomenal pumpkins at this year’s carving contest!

Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
October 25, 2025 at 12:31 AM
basicsci.fredhutch.org
The 2025 Pumpkin Carving Contest Kicks off at 4pm today! Can’t wait to see everyone and their amazing pumpkins!
Here’s what you need to know: • DATE: Friday, October 24th • TIME: 4pm (no Friday Afternoon Seminar this day) • LOCATION: Double Helix • PRIZE CATEGORIES: Most Artistic, Horrific, Scientific, Humorous • WINNERS will be announced at the event at 5pm!
October 24, 2025 at 6:08 PM
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It's a Basic Sciences double feature for Friday Afternoon Seminars! Excited to learn about the latest discoveries from Xiaohui Ju in the @jbloomlab.bsky.social and Matthew Chan in the @rasilab.bsky.social and @melodygcampbell.bsky.social Lab. See everyone at 4pm in Pelton for two great talks!
Friday Afternoon Seminars (FAS), this Friday 10/17 at 4pm in Pelton. Xiaohui Ju, Bloom Lab Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins Matthew Chan, Campbell and Subramaniam Labs From Atoms to Action: The Biophysics of Start Codon Selection
October 17, 2025 at 9:43 PM
basicsci.fredhutch.org
"Decoding the autoantibody reactome."

We’re excited to have @aaronmring.bsky.social joining us from the Translational Science and Therapeutics Division to share his latest research at today’s Current Biology Seminar! For all our @FredHutch.org colleagues, don’t miss a great talk at noon!
Current Biology Seminar presented by Dr. Ring, Fred Hutch. Dr. Ring’s seminar is hosted by the Division of Basic Sciences. Aaron Ring, PhD Associate Professor Translational Science and Therapeutics Division Fred Hutch Title: "Decoding the autoantibody reactome " 12:00pm on Tuesday, October 14, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
October 14, 2025 at 5:14 PM
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Friday Afternoon Seminars are back!
Kicking things off are @pravrutharaman.bsky.social from the @harmitmalik.bsky.social Lab and @christianloyo.bsky.social from Human Biology’s Salama Lab. Can’t wait to see everyone today at 4:00 pm in Pelton for two great talks!
Friday Afternoon Seminars (FAS), this Friday 10/10 at 4pm in Pelton. Pravrutha Raman, Malik Lab Beyond histone mimicry: evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals Christian Loyo, Salama Lab Adaptive benefits of mobile genetic elements in bacteria
October 10, 2025 at 9:55 PM
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For this Current Biology Seminar series, we’re hosting local luminaries from the pacific northwest. For the first talk of the series, we’re excited to have Dr. Eric Holland speaking today at noon in Pelton. For all our @FredHutch.org colleagues, don’t miss a great talk!
Eric Holland, MD, PhD Senior Vice President and Director Human Biology Division Fred Hutch Title: "Big data visualization and mouse models of cancer" 12:00pm on Tuesday, October 7, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
October 7, 2025 at 5:47 PM
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The 2025 Basic Sciences retreat continues today with talks from division faculty. Can’t wait to meet the first-year postbacs and @mcbseattle.bsky.social students. Excited for another great day of science!
September 19, 2025 at 3:02 PM
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The 2025 Basic Sciences retreat kicks off today at 2:00 p.m. with the main poster session in the Behnke Suites in Arnold Building. Can’t wait to hear about all the latest research happening in the division!
September 18, 2025 at 8:00 PM
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For all our @FredHutch.bsky.social colleagues, don’t miss a special talk today at noon hosted by the Fred Hutch Chromatin Club. We’re excited to have Dr. Zhiguo Zhang joining us from @columbiamed.bsky.social to share his latest discoveries on chromatin replication.
Zhiguo Zhang, PhD Institute for Cancer Genetics Professor of Epigenomics and Molecular Biology Department of Pediatrics Department of Genetics and Development Columbia University Irving Medical Center Title: “A Tale of Two Strands: Mechanistic Insights into Chromatin Replication Through Strand-Specific Sequencing” 12:00pm on Thursday, June 26, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
June 26, 2025 at 5:12 PM
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Celebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!
Biggins Lab 25th anniversary celebration Biggins Lab 25th anniversary celebration
June 18, 2025 at 9:17 PM
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"Unfolding RNA structure for its translation in cancer & therapy”

We’re excited to have @ruggerolab.bsky.social joining us from @ucsfurology.bsky.social to speak at today’s Current Biology Seminar. For all our @FredHutch.bsky.social colleagues, don’t miss the final talk of the series!
Dr. Ruggero’s seminar is hosted by the Division of Basic Sciences. Davide Ruggero, PhD Professor Goldberg-Benioff Endowed Professorship Helen Diller Family Comprehensive Cancer Center Departments of Urology and Cellular & Molecular Pharmacology School of Medicine University of California, San Francisco Title: "Unfolding RNA structure for its translation in cancer & therapy” 12:00pm on Tuesday, May 20, 2025 Sze Combo (D1-080/084), Thomas Building, Fred Hutch
May 20, 2025 at 4:58 PM
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Two great talks lined up for the final Friday Afternoon Seminars of the season!

For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
Friday Afternoon Seminar (FAS), this Friday 5/16 at 4pm in Pelton. Rina Hirano, Tsukiyama Lab Elucidating 3D chromatin structure and its regulatory mechanism of rDNA in quiescence Christina Kuismi, Nabet Lab Targeted degradation of non-receptor tyrosine kinases PYK2 and FAK
May 16, 2025 at 9:21 PM
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"Microbiota-Immune interactions that promote health"

We’re excited to have Dr. June Round joining us from the University of Utah Department of Pathology to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk!
Current Biology Seminar presented by Dr. Round, University of Utah. Dr. Round’s seminar is hosted by the Division of Basic Sciences. June Round, PhD Professor Department of Pathology University of Utah Title: "Microbiota-Immune interactions that promote health" 12:00pm on Tuesday, May 13, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
May 13, 2025 at 6:04 PM
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We’re excited to have Alex Kaiser from the Stoddard Lab and Jae Heun Cheung from Human Biology’s @davidmacphersonlab.bsky.social sharing their latest research at Friday Afternoon Seminars. For everyone @FredHutch.bsky.social, don’t miss two fantastic talks today at 4:00!
Friday Afternoon Seminars (FAS), this Friday 5/9 at 4pm in Pelton. Alex Kaiser, Stoddard Lab Bacterial islands of Defense: The BREX Antiviral Defense System Jae Heun Cheung, MacPherson Lab In vivo CRISPR activation screens identify potential drivers of chemoresistance in SCLC
May 9, 2025 at 10:06 PM
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"Unsupervised learning for genomics to decipher dynamics of 3D genome organization and gene regulatory networks”

We’re excited for a great talk from @sroyyors.bsky.social at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss it at noon in Pelton Auditorium.
Current Biology Seminar presented by Dr. Roy, University of Wisconsin-Madison. Dr. Roy’s seminar is hosted by the Division of Basic Sciences. Sushmita Roy, PhD Professor Department of Biostatistics and Medical Informatics Wisconsin Institute for Discovery University of Wisconsin-Madison Title: "Unsupervised learning for genomics to decipher dynamics of 3D genome organization and gene regulatory networks” 12:00pm on Tuesday, May 6, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
May 6, 2025 at 5:50 PM
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We have a Basic Sciences double feature at Friday Afternoon Seminars!

For all our @FredHutch.bsky.social colleagues, join us at 4:00 in Pelton to hear two great talks from Rose Bosire in the Adeyemi Lab and Sarah Leichter in the Henikoff Lab!
Friday Afternoon Seminars (FAS), this Friday 5/2 at 4pm in Pelton. Rose Bosire, Adeyemi Lab LncRNA LAC mediates replication stress response via regulation of Exonuclease 1 Sarah Leichter, HenikoffLab Single-cell chromatin profiling of Polycomb repression identifies gene misregulation in the aging intestine
May 2, 2025 at 9:49 PM
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"Nutritional Inheritance in Development and Disease"

We’re excited to have Dr. Monica Dus joining us from @umich.edu to share her latest research at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk at noon!
Current Biology Seminar presented by Dr. Dus, University of Michigan. Dr. Dus’s seminar is hosted by the Division of Basic Sciences. Monica Dus, PhD Director, Office of National Labs, The Office of the Vice President for Research Associate Professor, Department of Molecular, Cellular, and Developmental Biology University of Michigan Title: "Nutritional Inheritance in Development and Disease " 12:00pm on Tuesday, April 29, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
April 30, 2025 at 5:40 AM
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Excited for two great speakers at Friday Afternoon Seminars!

For everyone @FredHutch.bsky.social, join us at 4:00 in Pelton to hear Erin Ramsey
from the Eisenman Lab and Nick Salisbury from Human Biology’s Galloway Lab share their latest research!
Friday Afternoon Seminars (FAS), this Friday 4/25 at 4pm in Pelton. Nick Salisbury, Galloway Lab Turning genes on and off: E2F/NF-κB controls the switch between Merkel cell polyomavirus replication and latency Erin Ramsey, Eisenman Lab mRNA m6A Modification: A Key for Stress Regulation in MYC-driven Pancreatic Cancer
April 25, 2025 at 9:47 PM
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We want to thank the division’s research administrators for their immeasurable impact on Basic Sciences @FredHutch.bsky.social. From keeping labs supplied, managing funding, and resolving problems big and small, we’re grateful for what they do every day. #AdministrativeProfessionalsDay
Basic Sciences admin members during a facilities tour
April 23, 2025 at 4:40 PM