Wei-Chung Allen Lee
@darbly.bsky.social
circuit motifs of action selection, execution, & refinement | functional connectomics | assoc prof | lee.hms.harvard.edu
Pinned
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Meet Wangchu and connectomics in the spinal cord this afternoon at LBP077.04 / LBP036 #SFN25
Stop by Wangchu's poster Tuesday (11/18) afternoon to learn about circuit motifs supporting touch processing in the spinal cord.
November 18, 2025 at 4:15 PM
Meet Wangchu and connectomics in the spinal cord this afternoon at LBP077.04 / LBP036 #SFN25
Stop by Wangchu's poster Tuesday (11/18) afternoon to learn about circuit motifs supporting touch processing in the spinal cord.
November 18, 2025 at 6:07 AM
Stop by Wangchu's poster Tuesday (11/18) afternoon to learn about circuit motifs supporting touch processing in the spinal cord.
Reposted by Wei-Chung Allen Lee
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 3:40 PM
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Reposted by Wei-Chung Allen Lee
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)
thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
August 14, 2025 at 7:40 PM
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)
thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
Reposted by Wei-Chung Allen Lee
X-ray nanotomography can be your new friend for neuronal imaging. In our new #preprint (tinyurl.com/nanoXneuro) we present advances that push the spatial resolution limit for X-ray holographic nanotomography (XNH). We can now resolve synapses. 🧵
February 11, 2025 at 6:25 PM
X-ray nanotomography can be your new friend for neuronal imaging. In our new #preprint (tinyurl.com/nanoXneuro) we present advances that push the spatial resolution limit for X-ray holographic nanotomography (XNH). We can now resolve synapses. 🧵
Reposted by Wei-Chung Allen Lee
My PhD project is out as a preprint!
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
May 1, 2025 at 12:20 PM
My PhD project is out as a preprint!
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
Couldn't agree more. There’s still so much to be uncovered in the dataset.
One thing that wasn’t emphasized before is how it enables access to specific circuit motifs down to identified cells. 12 examples are highlighted in the preprint, but again just the tip of the iceberg.
One thing that wasn’t emphasized before is how it enables access to specific circuit motifs down to identified cells. 12 examples are highlighted in the preprint, but again just the tip of the iceberg.
There is so much to learn from this dataset that it's overwhelming. It feels amazing to connect everything, from the "cognitive" regions of the brain all the way down to muscles, internal organs, and endocrine systems. With the analyses in our preprint, we've only just scratched the surface.
August 10, 2025 at 9:14 PM
Couldn't agree more. There’s still so much to be uncovered in the dataset.
One thing that wasn’t emphasized before is how it enables access to specific circuit motifs down to identified cells. 12 examples are highlighted in the preprint, but again just the tip of the iceberg.
One thing that wasn’t emphasized before is how it enables access to specific circuit motifs down to identified cells. 12 examples are highlighted in the preprint, but again just the tip of the iceberg.
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
August 3, 2025 at 3:16 PM
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
August 3, 2025 at 3:51 AM
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Reposted by Wei-Chung Allen Lee
New preprint: "The geometry of the neural state space of decisions", work by Mauro Monsalve-Mercado, buff.ly/42wVHD5. Surprising results & predictions! (Thread) We analyze neuropixel population recordings in macaque area LIP during a reaction time, random-dot motion 1/
January 31, 2025 at 2:32 PM
New preprint: "The geometry of the neural state space of decisions", work by Mauro Monsalve-Mercado, buff.ly/42wVHD5. Surprising results & predictions! (Thread) We analyze neuropixel population recordings in macaque area LIP during a reaction time, random-dot motion 1/
Reposted by Wei-Chung Allen Lee
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...
bioRxiv: www.biorxiv.org/content/10.1...
Symmetries and Continuous Attractors in Disordered Neural Circuits
A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...
www.biorxiv.org
January 29, 2025 at 6:26 PM
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...
bioRxiv: www.biorxiv.org/content/10.1...
Thanks Albert, @jefferis.bsky.social, & Joergen for a wonderful visit. Future of connectomics is bright at the @mrclmb.bsky.social.
December 8, 2024 at 9:03 PM
Thanks Albert, @jefferis.bsky.social, & Joergen for a wonderful visit. Future of connectomics is bright at the @mrclmb.bsky.social.
Reposted by Wei-Chung Allen Lee
Excited about our minisymposium at @SfNtweets! Join us Wednesday afternoon to hear about the functional organization of lateral septum - from molecules to circuits and computations! Session details here: abstractsonline.com/pp8/#!/20433...
#sfn2024 #neuroscience
#sfn2024 #neuroscience
Program Planner
abstractsonline.com
October 7, 2024 at 6:51 PM
Excited about our minisymposium at @SfNtweets! Join us Wednesday afternoon to hear about the functional organization of lateral septum - from molecules to circuits and computations! Session details here: abstractsonline.com/pp8/#!/20433...
#sfn2024 #neuroscience
#sfn2024 #neuroscience
Amazed seeing @bdsc.bsky.social in person the other week. Remarkably, they maintain >100,000 fly lines - with geo-redundancy - and provide them to users around the world! A vital scientific resource.
October 6, 2024 at 1:35 AM
Amazed seeing @bdsc.bsky.social in person the other week. Remarkably, they maintain >100,000 fly lines - with geo-redundancy - and provide them to users around the world! A vital scientific resource.
Reposted by Wei-Chung Allen Lee
Come see two of our lab projects tomorrow morning at SfN.
Fabricio will present behavior, closed loop opto, and EMG in a really cool mouse jumping behavior: E32
Praising (Jerry) will present Neuropixel recordings from the spinal cords of awake behaving mice performing simple reflexes: G12
Fabricio will present behavior, closed loop opto, and EMG in a really cool mouse jumping behavior: E32
Praising (Jerry) will present Neuropixel recordings from the spinal cords of awake behaving mice performing simple reflexes: G12
October 5, 2024 at 11:42 PM
Come see two of our lab projects tomorrow morning at SfN.
Fabricio will present behavior, closed loop opto, and EMG in a really cool mouse jumping behavior: E32
Praising (Jerry) will present Neuropixel recordings from the spinal cords of awake behaving mice performing simple reflexes: G12
Fabricio will present behavior, closed loop opto, and EMG in a really cool mouse jumping behavior: E32
Praising (Jerry) will present Neuropixel recordings from the spinal cords of awake behaving mice performing simple reflexes: G12
Reposted by Wei-Chung Allen Lee
UCSF Francisco researcher Corey Harwell talks about his own biography first Louisville. He is showing data about the town, maps of ethnicities. 🧠🧪 Took part in MARC program at Tennessee State = Maximizing Access to Research Careers. Also: summer research program stints.
October 5, 2024 at 8:09 PM
UCSF Francisco researcher Corey Harwell talks about his own biography first Louisville. He is showing data about the town, maps of ethnicities. 🧠🧪 Took part in MARC program at Tennessee State = Maximizing Access to Research Careers. Also: summer research program stints.
Reposted by Wei-Chung Allen Lee
Our fly brain connectome papers are now live (www.nature.com/immersive/d4...), and is getting traction (www.bbc.co.uk/news/article...). With ~139k neurons, >8k cell types, synapses annotated, transmitters predicted, ~134 evo-devo units denoted, so much is now possible in the fly.
October 3, 2024 at 12:26 AM
Our fly brain connectome papers are now live (www.nature.com/immersive/d4...), and is getting traction (www.bbc.co.uk/news/article...). With ~139k neurons, >8k cell types, synapses annotated, transmitters predicted, ~134 evo-devo units denoted, so much is now possible in the fly.
Reposted by Wei-Chung Allen Lee
The fly now has a full #connectome, in its most basic form a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory/modulatory? Our new, now published work moves towards this answer, predicting #neurotransmitters from EM! 1/n
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
May 19, 2024 at 2:07 AM
The fly now has a full #connectome, in its most basic form a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory/modulatory? Our new, now published work moves towards this answer, predicting #neurotransmitters from EM! 1/n
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Wei-Chung Allen Lee
Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...
The FlyWire connectome: neuronal wiring diagram of a complete fly brain
Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...
www.nature.com
October 2, 2024 at 7:08 PM
Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...
The essential parts list.
And our contribution to FlyWire, cell typing the connectome with @jefferis.bsky.social and colleagues, is here: www.nature.com/articles/s41...
Whole-brain annotation and multi-connectome cell typing of Drosophila
Nature - A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.
www.nature.com
October 3, 2024 at 3:07 AM
The essential parts list.
Excited to see this out: rdcu.be/dzfgM
Congratulations Aaron Kuan (now with a new lab at Yale), Giulio Bondanelli, and all who made this years-long work on neural circuits supporting decision-making possible!
#neuroscience
Congratulations Aaron Kuan (now with a new lab at Yale), Giulio Bondanelli, and all who made this years-long work on neural circuits supporting decision-making possible!
#neuroscience
February 22, 2024 at 1:59 PM
Excited to see this out: rdcu.be/dzfgM
Congratulations Aaron Kuan (now with a new lab at Yale), Giulio Bondanelli, and all who made this years-long work on neural circuits supporting decision-making possible!
#neuroscience
Congratulations Aaron Kuan (now with a new lab at Yale), Giulio Bondanelli, and all who made this years-long work on neural circuits supporting decision-making possible!
#neuroscience