Dantong Zhu
dantong-zhu.bsky.social
Dantong Zhu
@dantong-zhu.bsky.social
Research Scientist at Institute for Systems Biology. Interested in multi-omics biomarkers for aging and frailty, also an entomologist
Reposted by Dantong Zhu
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....

What a tremendous honor! Congratulations!
October 6, 2025 at 4:19 PM
Check out our new paper about metabolite biomarkers for frailty in mice. Age- and frailty-related metabolites are different and present sex dimorphisms www.nature.com/articles/s41...
Thanks to @alicekane.bsky.social @judywbio.bsky.social & other authors
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice - npj Aging
npj Aging - Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice
www.nature.com
May 31, 2025 at 6:18 PM
Reposted by Dantong Zhu
👏 Big congrats to our 2025 Data Blitz Award winners!

🏅 PostDocs: Min Hoo Kim, and Dantong Zhu
🏅 Techs/Grad Students: Mahima Devarajan, and Michaela Vance.

Incredible science from rising stars!
#AGEAnnualMeeting2025 #AgingResearch #DataBlitz #YoungScientists
May 23, 2025 at 6:36 PM
Reposted by Dantong Zhu
Check out our latest preprint on the development of clocks to predict PhenoAge in mice! www.biorxiv.org/content/10.1...
Multiomic clocks to predict phenotypic age in mice
Biological age refers to a person's overall health in aging, as distinct from their chronological age. Diverse measures of biological age, referred to as clocks, have been developed in recent years an...
www.biorxiv.org
May 6, 2025 at 4:34 PM
Reposted by Dantong Zhu
Data request! Do you assess frailty index in your aging C57 mouse studies? @dantong-zhu.bsky.social is making new and improved clocks to predict age and lifespan based on frailty data & we aim to validate widely! Reach out if you want to collaborate 🐀👵⏰ Especially if you have female data + lifespan!
February 28, 2025 at 8:01 PM
Reposted by Dantong Zhu

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

"...In summary, our results identify sex-specific metabolite biomarkers of frailty in aging, and shed light on potential mechanisms involved in frailty"

@alicekane.bsky.social

www.biorxiv.org/content/10.1...
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice
Frailty is an age related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured fr...
www.biorxiv.org
January 23, 2025 at 8:54 PM
Reposted by Dantong Zhu
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice https://www.biorxiv.org/content/10.1101/2025.01.22.634160v1
January 22, 2025 at 11:46 PM
Reposted by Dantong Zhu
Check out the first publication from the Kane lab @isbscience.org! RNAseq analysis of sex differences in aging across tissues - spoiler alert - there are lots of them! bsd.biomedcentral.com/articles/10.... Congratulations and thans to @dantong-zhu.bsky.social, @judywbio.bsky.social & other authors.
Sex dimorphism and tissue specificity of gene expression changes in aging mice - Biology of Sex Differences
Background Aging is a complex process that involves all tissues in an organism and shows sex dimorphism. While transcriptional changes in aging have been well characterized, the majority of studies ha...
bsd.biomedcentral.com
January 2, 2025 at 8:23 PM