DanBrownPhD
@danbrownphd.bsky.social
Scientist, husband, father, baker
Reposted by DanBrownPhD
We are failing our kids
December 16, 2025 at 3:06 PM
We are failing our kids
Reposted by DanBrownPhD
New data is live!! With 25 new kinases, we have a total of 420,497 drug-target interaction results! There are multiple ways to access the dataset 🧵
December 11, 2025 at 11:04 PM
New data is live!! With 25 new kinases, we have a total of 420,497 drug-target interaction results! There are multiple ways to access the dataset 🧵
Reposted by DanBrownPhD
Day 5 of our kinase preview for our imminent data release: Emerging Oncology Targets
We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.
We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.
December 9, 2025 at 2:38 PM
Day 5 of our kinase preview for our imminent data release: Emerging Oncology Targets
We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.
We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.
Reposted by DanBrownPhD
It's the final day of our data release preview -- data will be posted tomorrow!
The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2
The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2
December 10, 2025 at 9:41 PM
It's the final day of our data release preview -- data will be posted tomorrow!
The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2
The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2
Reposted by DanBrownPhD
Reposted by DanBrownPhD
It's data release week at EvE! Continuing with day 4 of our preview of the 25 kinases we'll release later this week, today's focus is on stress and survival pathways.
We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.
We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.
December 8, 2025 at 2:38 PM
It's data release week at EvE! Continuing with day 4 of our preview of the 25 kinases we'll release later this week, today's focus is on stress and survival pathways.
We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.
We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.
Reposted by DanBrownPhD
Day 2 preview of EvE's kinase data release: The RSK Family
We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K.
These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.
We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K.
These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.
December 5, 2025 at 11:04 PM
Day 2 preview of EvE's kinase data release: The RSK Family
We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K.
These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.
We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K.
These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.
Reposted by DanBrownPhD
For the day 3 preview of EvE's kinase data release, the theme is calcium.
We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.
We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.
December 7, 2025 at 4:12 PM
For the day 3 preview of EvE's kinase data release, the theme is calcium.
We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.
We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.
Reposted by DanBrownPhD
At EvE, we release data regularly, and our next release is coming up next week! We're adding 25 more kinases to our public drug-target interaction dataset.
Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family
Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family
December 5, 2025 at 1:21 AM
At EvE, we release data regularly, and our next release is coming up next week! We're adding 25 more kinases to our public drug-target interaction dataset.
Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family
Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family
Reposted by DanBrownPhD
Would MAGAs stop hoovering Elon Musk's sharts if they knew how to read charts?
(By the way, in the last chart here, the cash held by the richest Americans is so vast it's 10 times the height of the chart and can't be shown. Never forget, it's not democratic socialists who hate us but billionaires.)
(By the way, in the last chart here, the cash held by the richest Americans is so vast it's 10 times the height of the chart and can't be shown. Never forget, it's not democratic socialists who hate us but billionaires.)
December 3, 2025 at 7:35 PM
Would MAGAs stop hoovering Elon Musk's sharts if they knew how to read charts?
(By the way, in the last chart here, the cash held by the richest Americans is so vast it's 10 times the height of the chart and can't be shown. Never forget, it's not democratic socialists who hate us but billionaires.)
(By the way, in the last chart here, the cash held by the richest Americans is so vast it's 10 times the height of the chart and can't be shown. Never forget, it's not democratic socialists who hate us but billionaires.)
Reposted by DanBrownPhD
We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! 🧪
evebio.org/pharmome-dat...
Here's what's new: 🧵
evebio.org/pharmome-dat...
Here's what's new: 🧵
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 7:48 PM
We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! 🧪
evebio.org/pharmome-dat...
Here's what's new: 🧵
evebio.org/pharmome-dat...
Here's what's new: 🧵
Reposted by DanBrownPhD
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 3:44 PM
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Reposted by DanBrownPhD
Boy, North Carolina Republicans sure don't want the attached story to circulate. I sure hope that this stupid threat from their spokesperson doesn't boomerang on them and have a lot more people read and share the story, which once again, is conveniently attached below. That would be a shame.
October 30, 2025 at 3:41 PM
Boy, North Carolina Republicans sure don't want the attached story to circulate. I sure hope that this stupid threat from their spokesperson doesn't boomerang on them and have a lot more people read and share the story, which once again, is conveniently attached below. That would be a shame.
Reposted by DanBrownPhD
If this country was truly “pro-life,” we would have Medicare for All, a Green New Deal, gun reform, universal child care, and a living wage.
The right-wing agenda isn’t about “life.”
It’s about control.
The right-wing agenda isn’t about “life.”
It’s about control.
October 2, 2025 at 6:45 PM
If this country was truly “pro-life,” we would have Medicare for All, a Green New Deal, gun reform, universal child care, and a living wage.
The right-wing agenda isn’t about “life.”
It’s about control.
The right-wing agenda isn’t about “life.”
It’s about control.
Reposted by DanBrownPhD
The president is sending the military to control American cities and if you're a reporter who's framing that illegal power grab as "pushing the boundaries of constitutionality" or "acting boldly to fight crime" or whatever, please go find another line of work where you won't get us all killed.
September 2, 2025 at 8:56 PM
The president is sending the military to control American cities and if you're a reporter who's framing that illegal power grab as "pushing the boundaries of constitutionality" or "acting boldly to fight crime" or whatever, please go find another line of work where you won't get us all killed.
Reposted by DanBrownPhD
🧪 Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic.
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠
www.owlposting.com/p/mapping-th...
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠
www.owlposting.com/p/mapping-th...
Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio)
6.2k words, 29 minutes reading time
www.owlposting.com
July 14, 2025 at 2:02 PM
🧪 Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic.
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠
www.owlposting.com/p/mapping-th...
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠
www.owlposting.com/p/mapping-th...
Reposted by DanBrownPhD
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪
July 22, 2025 at 4:01 PM
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪
Reposted by DanBrownPhD
Scenes from a science crisis: a selection of recent developments 🧵1/6
July 18, 2025 at 1:39 PM
Scenes from a science crisis: a selection of recent developments 🧵1/6
Reposted by DanBrownPhD
It's remarkable that the Biden administration spent money on rural red areas, which then voted enthusiastically for Trump, who has now repeatedly made moves to screw over those exact same areas.
July 18, 2025 at 1:30 PM
It's remarkable that the Biden administration spent money on rural red areas, which then voted enthusiastically for Trump, who has now repeatedly made moves to screw over those exact same areas.
Reposted by DanBrownPhD
Jeffries: "You got some people in the town who go to church and pray on Sunday, and then they come to Congress and prey on the American people. I'm not down with that kind of faith. That's not the faith that comes out of the Gospel."
July 3, 2025 at 5:13 PM
Jeffries: "You got some people in the town who go to church and pray on Sunday, and then they come to Congress and prey on the American people. I'm not down with that kind of faith. That's not the faith that comes out of the Gospel."
Reposted by DanBrownPhD
June 24, 2025 at 11:06 PM
Reposted by DanBrownPhD
🧪 Exciting to see EvE Bio's ever-expanding pharmome mapping dataset (data.evebio.org) cited as a source of training/test data for @futurehousesf.bsky.social's ether0 LLM, a new scientific reasoning model for chemistry. Preprint: storage.googleapis.com/aviary-publi...
Eve Bio: Pharmome Data
Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.
data.evebio.org
June 5, 2025 at 8:32 PM
🧪 Exciting to see EvE Bio's ever-expanding pharmome mapping dataset (data.evebio.org) cited as a source of training/test data for @futurehousesf.bsky.social's ether0 LLM, a new scientific reasoning model for chemistry. Preprint: storage.googleapis.com/aviary-publi...
Reposted by DanBrownPhD
All to pay for tax breaks for the rich.
July 2, 2025 at 12:13 PM
All to pay for tax breaks for the rich.
Reposted by DanBrownPhD
Call me crazy, but my idea of making America great involves a lot fewer kidnappings and concentration camps.
July 2, 2025 at 12:10 PM
Call me crazy, but my idea of making America great involves a lot fewer kidnappings and concentration camps.
Reposted by DanBrownPhD
July 1, 2025 at 11:58 AM