Cynthia Turnbull
@cynturnbull.bsky.social
Post-doctoral researcher at JCSMR/ANU studying the role of modifier genes in cancer and autoimmunity
Reposted by Cynthia Turnbull
Congratulations to all our #ASBMB2025 award winners! 🏆 Part of being a society is celebrating the success of our community, so cheers to all of you! 💯💯
October 1, 2025 at 2:02 AM
Congratulations to all our #ASBMB2025 award winners! 🏆 Part of being a society is celebrating the success of our community, so cheers to all of you! 💯💯
Reposted by Cynthia Turnbull
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine
In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...
nature.com
August 27, 2025 at 3:06 PM
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Cynthia Turnbull
Nature research paper: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
go.nature.com/3JnVASZ
go.nature.com/3JnVASZ
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature
The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.
go.nature.com
August 27, 2025 at 8:38 AM
Nature research paper: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
go.nature.com/3JnVASZ
go.nature.com/3JnVASZ
Thrilled to see James P Allison present at #IUIS2025. His work on CTLA-4 and immune checkpoint blockade fundamentally changed the way we treat cancer, putting immunotherapy on the map, which has saved so many lives. What a wonderful way to end this conference.
August 22, 2025 at 3:01 PM
Thrilled to see James P Allison present at #IUIS2025. His work on CTLA-4 and immune checkpoint blockade fundamentally changed the way we treat cancer, putting immunotherapy on the map, which has saved so many lives. What a wonderful way to end this conference.
Excellent presentation by #IUIS2025 rising star Deborah Burnett @debburnett.bsky.social touching on the theory of clonal redemption in B cells.
Congrats Debbie! 🥳
Congrats Debbie! 🥳
August 22, 2025 at 11:26 AM
Excellent presentation by #IUIS2025 rising star Deborah Burnett @debburnett.bsky.social touching on the theory of clonal redemption in B cells.
Congrats Debbie! 🥳
Congrats Debbie! 🥳
Phenomenal work by Sophie Shen @sophieshen.bsky.social and Carola Vinuesa @carovinuesa.bsky.social
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at #IUIS2025. Read more in the paper released yesterday in Nature: www.nature.com/articles/s41...
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at #IUIS2025. Read more in the paper released yesterday in Nature: www.nature.com/articles/s41...
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature
The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.
www.nature.com
August 21, 2025 at 2:46 PM
Phenomenal work by Sophie Shen @sophieshen.bsky.social and Carola Vinuesa @carovinuesa.bsky.social
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at #IUIS2025. Read more in the paper released yesterday in Nature: www.nature.com/articles/s41...
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at #IUIS2025. Read more in the paper released yesterday in Nature: www.nature.com/articles/s41...
Gabriel Victora @victora.bsky.social delighting everyone at #IUIS2025 with his elegant work on germinal centres, or “Darwinian evolution inside your armpit”. Check out his latest preprint replaying GC evolution on a quantified affinity landscape here: www.biorxiv.org/content/10.1...
August 20, 2025 at 1:01 PM
Gabriel Victora @victora.bsky.social delighting everyone at #IUIS2025 with his elegant work on germinal centres, or “Darwinian evolution inside your armpit”. Check out his latest preprint replaying GC evolution on a quantified affinity landscape here: www.biorxiv.org/content/10.1...
Reposted by Cynthia Turnbull
In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵
Inference of germinal center evolutionary dynamics via simulation-based deep learning
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...
arxiv.org
August 16, 2025 at 10:56 PM
In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵
Very excited participate in the 19th International Congress of Immunology, #IUIS2025 in Vienna. “Where immunologists meet” with over 3000 delegates from 104 countries and 320 oral presentations!
August 19, 2025 at 3:26 PM
Very excited participate in the 19th International Congress of Immunology, #IUIS2025 in Vienna. “Where immunologists meet” with over 3000 delegates from 104 countries and 320 oral presentations!
Explored the Kunsthistorisches Museum Wien, “Museum of Art History” in Vienna.
Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper.
The building itself is a work of art.
Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper.
The building itself is a work of art.
August 17, 2025 at 4:23 PM
Explored the Kunsthistorisches Museum Wien, “Museum of Art History” in Vienna.
Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper.
The building itself is a work of art.
Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper.
The building itself is a work of art.
Honoured to receive the ACT/NSW 7News Young Achiever Award for Academic Achievement (also sponsored by Western Sydney University). It was a bit of a chaotic night flying back from Hawaii! A big thank you to my Dad for meeting me in Sydney and driving me back home!
May 6, 2025 at 12:07 PM
Honoured to receive the ACT/NSW 7News Young Achiever Award for Academic Achievement (also sponsored by Western Sydney University). It was a bit of a chaotic night flying back from Hawaii! A big thank you to my Dad for meeting me in Sydney and driving me back home!
Reposted by Cynthia Turnbull
Somatic mutation as an explanation for epigenetic aging @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
www.nature.com
January 13, 2025 at 6:27 PM
Somatic mutation as an explanation for epigenetic aging @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...