Ed Twomey
@cryoet.bsky.social
Scientist. Structure and function of cell-cell communication with a special interest in neurons & cryo-EM. All opinions are my own.
Here's our new preprint led by @wdhale.bsky.social with @rhuganir.bsky.social:
"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"
www.biorxiv.org/content/10.1...
#iGluRs #cryoEM
Some key points below that Dylan discovered:
"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"
www.biorxiv.org/content/10.1...
#iGluRs #cryoEM
Some key points below that Dylan discovered:
June 16, 2025 at 2:19 PM
Here's our new preprint led by @wdhale.bsky.social with @rhuganir.bsky.social:
"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"
www.biorxiv.org/content/10.1...
#iGluRs #cryoEM
Some key points below that Dylan discovered:
"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"
www.biorxiv.org/content/10.1...
#iGluRs #cryoEM
Some key points below that Dylan discovered:
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
March 26, 2025 at 4:29 PM
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
We took a precise look at how claudin-like tetraspanins (TARPs) regulate AMPA receptors. #CryoEM helped us identify motifs that are critical for receptor regulation, and point to how TARPs evolved from claudins to a regulatory role in the CNS vs. tissue barriers like claudins! rdcu.be/d6DOu
January 17, 2025 at 4:12 PM
We took a precise look at how claudin-like tetraspanins (TARPs) regulate AMPA receptors. #CryoEM helped us identify motifs that are critical for receptor regulation, and point to how TARPs evolved from claudins to a regulatory role in the CNS vs. tissue barriers like claudins! rdcu.be/d6DOu