Ed Twomey
@cryoet.bsky.social
Scientist. Structure and function of cell-cell communication with a special interest in neurons & cryo-EM. All opinions are my own.
Thank you! Much appreciated. Hope you are doing well!
September 16, 2025 at 10:40 PM
Thank you! Much appreciated. Hope you are doing well!
#Neuroscience #BrainDiscovery #NewTherapies #DeltaReceptor #Glutamate #ScienceBreakthrough #SynapticTransmission #CryoEM #iGluR
September 16, 2025 at 4:47 PM
This completely rewrites the textbooks on how brains process information, and completes the iGluR family. An additional fun fact is that despite being glutamate receptors, these are not activated by glutamate, but rather the neurotransmitters GABA and D-serine.
September 16, 2025 at 4:47 PM
This completely rewrites the textbooks on how brains process information, and completes the iGluR family. An additional fun fact is that despite being glutamate receptors, these are not activated by glutamate, but rather the neurotransmitters GABA and D-serine.
Why is this important? Despite their role in brain health, neurological disease, and psychiatric disorders, no treatments have been developed to target GluDs because their intrinsic mechanisms have been unknown. This work lifts that veil to open new doors for therapeutic development.
September 16, 2025 at 4:47 PM
Why is this important? Despite their role in brain health, neurological disease, and psychiatric disorders, no treatments have been developed to target GluDs because their intrinsic mechanisms have been unknown. This work lifts that veil to open new doors for therapeutic development.
Today, we report the solving of this mystery: delta receptors are actually ligand-gated ion channels - tiny biological switches that power brain activity and learning by turning neurotransmitters into electrical signal.
September 16, 2025 at 4:47 PM
Today, we report the solving of this mystery: delta receptors are actually ligand-gated ion channels - tiny biological switches that power brain activity and learning by turning neurotransmitters into electrical signal.
For decades, scientists have puzzled over the delta glutamate receptors (GluDs), mysterious proteins in the brain that are vital for synapse formation and maintenance, and are directly implicated in psychiatric and neurological disorders, but whose true function was unknown.
September 16, 2025 at 4:47 PM
For decades, scientists have puzzled over the delta glutamate receptors (GluDs), mysterious proteins in the brain that are vital for synapse formation and maintenance, and are directly implicated in psychiatric and neurological disorders, but whose true function was unknown.
This is fantastic - glad to see it out!
August 30, 2025 at 8:41 PM
This is fantastic - glad to see it out!