🚨🧠🔬 A major breakthrough in molecular neuroscience:

I am excited to share a new story from our lab, published in accelerated format today by @nature.com:

"Delta-type glutamate receptors are ligand-gated ion channels"

Read more here (free article link): rdcu.be/eGIKz

Post an image from your summer that confers peace.

(from the Telluride ion channels workshop)

Here's our new preprint led by @wdhale.bsky.social with @rhuganir.bsky.social:

"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"

www.biorxiv.org/content/10.1...

#iGluRs #cryoEM

Some key points below that Dylan discovered:

Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.

www.nature.com/articles/s41...
www.nature.com/articles/d41...

Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com

We took a precise look at how claudin-like tetraspanins (TARPs) regulate AMPA receptors. #CryoEM helped us identify motifs that are critical for receptor regulation, and point to how TARPs evolved from claudins to a regulatory role in the CNS vs. tissue barriers like claudins! rdcu.be/d6DOu

New development in #cryoEM specimen preparation from the Efremov lab that enables structure determination from a single plate of cells. Will be exciting to see how this revolutionizes low copy structure determination and investigations from native sources.

www.biorxiv.org/content/10.1...