@corrylab.bsky.social
Computational protein research group of Prof Ben Corry.
We love molecular dynamics and all kinds of membrane proteins including ion channels, transporters and immune receptors
~Posts by group members
We love molecular dynamics and all kinds of membrane proteins including ion channels, transporters and immune receptors
~Posts by group members
Great to see this paper with @elainetao.bsky.social out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated channel superfamily members #ionchannel #AI #StructuralBiology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 16, 2025 at 3:10 AM
Great to see this paper with @elainetao.bsky.social out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated channel superfamily members #ionchannel #AI #StructuralBiology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org
www.lorneproteins.org
July 25, 2025 at 11:30 AM
📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org
www.lorneproteins.org
2 yrs ago @yiechanglin.bsky.social sent me this movie of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @charlesdcox.bsky.social &Zhang lab. tiny.cc/tmem63
July 27, 2025 at 10:59 PM
2 yrs ago @yiechanglin.bsky.social sent me this movie of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @charlesdcox.bsky.social &Zhang lab. tiny.cc/tmem63
Applications for this position are closing tomorrow! Get yours in quickly 😁
🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
July 19, 2025 at 2:03 AM
Applications for this position are closing tomorrow! Get yours in quickly 😁
🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
June 17, 2025 at 2:27 AM
🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
Join us at #scienceanu with amazing collaborators and great working conditions!
Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2)
tiny.cc/PfCRT
tiny.cc/PfCRT
March 27, 2025 at 3:55 AM
Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2)
tiny.cc/PfCRT
tiny.cc/PfCRT
Also bittersweet to announce the final work of @elainetao.bsky.social in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao & are so proud of you 🎩
tiny.cc/VSD-AF2
tiny.cc/VSD-AF2
March 17, 2025 at 9:29 AM
Also bittersweet to announce the final work of @elainetao.bsky.social in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao & are so proud of you 🎩
tiny.cc/VSD-AF2
tiny.cc/VSD-AF2
Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩
1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations..
www.biorxiv.org/content/10.1101/2025.03.12.642747v1
www.biorxiv.org/content/10.1101/2025.03.12.642747v1
March 17, 2025 at 9:07 AM
Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩
Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers
tiny.cc/oligomers
March 16, 2025 at 6:37 AM
Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers
tiny.cc/oligomers
Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social 🔪🎆👩🔬👩🎓
March 14, 2025 at 6:39 AM
Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social 🔪🎆👩🔬👩🎓
Reposted
Anders ECR session Ruitao Jin: plant Ca ion channels. Mechanical gating of OSCA channels. 100s of subtypes sense and react to physical forces. Homodimers with protomer pore and cleft. Liposome inside-in structure. Membrane belt-MD avg position of lipid head group. Contribute to ion selectivity 🤩
February 10, 2025 at 10:15 AM
Anders ECR session Ruitao Jin: plant Ca ion channels. Mechanical gating of OSCA channels. 100s of subtypes sense and react to physical forces. Homodimers with protomer pore and cleft. Liposome inside-in structure. Membrane belt-MD avg position of lipid head group. Contribute to ion selectivity 🤩
Big congratulations to @riottowow.bsky.social .bsky.social for winning an Anders Early Career Award at @lorneproteins.bsky.social ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel. #lorneproteins2025
February 10, 2025 at 10:20 AM
Big congratulations to @riottowow.bsky.social .bsky.social for winning an Anders Early Career Award at @lorneproteins.bsky.social ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel. #lorneproteins2025
Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵
💻 by @ciarawallis.bsky.social & @riottowow.bsky.social
💻 by @ciarawallis.bsky.social & @riottowow.bsky.social
January 21, 2025 at 10:55 AM
Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵
💻 by @ciarawallis.bsky.social & @riottowow.bsky.social
💻 by @ciarawallis.bsky.social & @riottowow.bsky.social
Excited to be going to #bps2025 in LA!
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
January 21, 2025 at 5:59 AM
Excited to be going to #bps2025 in LA!
I should have included one of the nice figures from the paper!
rupress.org/jgp/article-...
rupress.org/jgp/article-...
January 8, 2025 at 3:09 AM
I should have included one of the nice figures from the paper!
rupress.org/jgp/article-...
rupress.org/jgp/article-...
Excited to start the year with this paper with
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70
Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the
hubs.la
January 8, 2025 at 2:20 AM
Excited to start the year with this paper with
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70
Season's Greetings from our (lab) family to yours! P.s. can you guess which lab member is which?? 🎄🎅🍪
Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️
Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️
December 18, 2024 at 10:36 AM
Season's Greetings from our (lab) family to yours! P.s. can you guess which lab member is which?? 🎄🎅🍪
Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️
Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️
Reposted
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
December 4, 2024 at 12:07 AM
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
Reposted
We’ve had nearly 3 years of review, review, review.
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
Falling enrolments and funding cuts force Australian universities to take stock
The Australian Universities Accord offers a roadmap for reform, but there are major challenges ahead.
www.nature.com
November 29, 2024 at 5:13 AM
We’ve had nearly 3 years of review, review, review.
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
Reposted
Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
November 27, 2024 at 8:43 PM
Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
#IonChannel #cryoem
www.biorxiv.org/content/10.1...
I'm following the Friday trend to make my own word scramble. Mine is a bit of a historical mess, but lots of fun to try
scholargoggler.com
scholargoggler.com
November 22, 2024 at 12:21 PM
I'm following the Friday trend to make my own word scramble. Mine is a bit of a historical mess, but lots of fun to try
scholargoggler.com
scholargoggler.com
It's great to be back in Canberra with my wonderful (and prize-winning) lab talking about channels, transporters, lipids, and simulations while drinking boba #scienceanu
November 22, 2024 at 12:01 PM
It's great to be back in Canberra with my wonderful (and prize-winning) lab talking about channels, transporters, lipids, and simulations while drinking boba #scienceanu
Reposted
Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
November 16, 2024 at 3:53 AM
Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Feel free to share, add and distribute, so we can come together again! 😍
go.bsky.app/AEeXh86
Reposted
May be a bit premature, but here is the Starter Pack I am trying to populate for #IonChannel research. Ping me and I’ll add you obviously! (Or to be removed)
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
November 19, 2024 at 2:26 PM
May be a bit premature, but here is the Starter Pack I am trying to populate for #IonChannel research. Ping me and I’ll add you obviously! (Or to be removed)
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
go.bsky.app/6taxHfx
@jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
Reposted
November 19, 2024 at 1:27 PM