Cornellab
@cornellab.bsky.social
Synthesis focus, catalysis driven
MPI für Kohlenforschung
www.cornellab.com
MPI für Kohlenforschung
www.cornellab.com
Reposted by Cornellab
New online! Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles
Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles
Nature Catalysis, Published online: 31 October 2025; doi:10.1038/s41929-025-01438-yThe Heck reaction is widely used in modern organic chemistry. Here the authors provide an alternative approach to common transition-metal catalysis, leveraging access to Bi(II) species thanks to bismuth’s photophysical properties.
bit.ly
October 31, 2025 at 10:39 AM
New online! Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles
Ambiphilic cross-coupling.
October 14, 2025 at 8:56 AM
Ambiphilic cross-coupling.
Reposted by Cornellab
🔥 An approach for light-driven, Ni-catalyzed C-heteroatom couplings that:
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
July 30, 2025 at 12:46 PM
🔥 An approach for light-driven, Ni-catalyzed C-heteroatom couplings that:
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
Reposted by Cornellab
Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟
#nickel
👉 buff.ly/BabxqGG
#nickel
👉 buff.ly/BabxqGG
September 26, 2025 at 7:01 AM
Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟
#nickel
👉 buff.ly/BabxqGG
#nickel
👉 buff.ly/BabxqGG
Reposted by Cornellab
🚨Calling medicinal chemists🚨:
A Suzuki het-het coupling sometimes does not require complex ligands. An air stable Ni would do. Amazing work from Rakan Saeb and Byeongdo Roh.
onlinelibrary.wiley.com/doi/10.1002/...
A Suzuki het-het coupling sometimes does not require complex ligands. An air stable Ni would do. Amazing work from Rakan Saeb and Byeongdo Roh.
onlinelibrary.wiley.com/doi/10.1002/...
February 21, 2025 at 3:39 PM
🚨Calling medicinal chemists🚨:
A Suzuki het-het coupling sometimes does not require complex ligands. An air stable Ni would do. Amazing work from Rakan Saeb and Byeongdo Roh.
onlinelibrary.wiley.com/doi/10.1002/...
A Suzuki het-het coupling sometimes does not require complex ligands. An air stable Ni would do. Amazing work from Rakan Saeb and Byeongdo Roh.
onlinelibrary.wiley.com/doi/10.1002/...
Deciphering the mechanism of oxidative addition of aryl iodides into a red-light active bismuthinidene. Incredible team: Alexios Stamoulis, Mauro Mato, Paolo Cleto-Bruzzese, M. Leutzsch, M. Gil-Sepulcre, A. Cadranel and F. Neese.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
February 10, 2025 at 5:16 PM
Deciphering the mechanism of oxidative addition of aryl iodides into a red-light active bismuthinidene. Incredible team: Alexios Stamoulis, Mauro Mato, Paolo Cleto-Bruzzese, M. Leutzsch, M. Gil-Sepulcre, A. Cadranel and F. Neese.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Transmetalating a challenging tetrel: introducing aryl-[Si] synthons into bismuth organometallic catalysis. Great work spearheaded by Teresa and Sophia. onlinelibrary.wiley.com/doi/10.1002/...
February 10, 2025 at 5:05 PM
Transmetalating a challenging tetrel: introducing aryl-[Si] synthons into bismuth organometallic catalysis. Great work spearheaded by Teresa and Sophia. onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Cornellab
The OMCOS-22 website has been updated. Registration and abstract submission are now open. Dr. Josep Cornella has been selected as the recipient of the OMCOS 22 Award. We congratulate Dr. Cornella and look forward to his award lecture in Kyoto. #OMCOS-22 omcos22.org
OMCOS XXII 22nd International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis
22nd International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis Kyoto, Japan, Sep 1-5, 2025
omcos22.org
February 3, 2025 at 11:25 AM
The OMCOS-22 website has been updated. Registration and abstract submission are now open. Dr. Josep Cornella has been selected as the recipient of the OMCOS 22 Award. We congratulate Dr. Cornella and look forward to his award lecture in Kyoto. #OMCOS-22 omcos22.org
Reposted by Cornellab
Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
Scripps Research professor awarded the 2025 Nichols Medal by American Chemical Society - Scripps Research Magazine
In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Re...
magazine.scripps.edu
January 7, 2025 at 8:55 PM
Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.