Colton Lysaker, PhD
@coltlys.bsky.social
APOE 🧬 and Metabolism | Postdoc @UniversityofKentucky | Rock Chalk, Jayhawk ☕🧠 @KUMedCenter Alum @UWPlatteville Alum ⛏️🫀
Reposted by Colton Lysaker, PhD
So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social
December 5, 2025 at 4:54 AM
So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social
Reposted by Colton Lysaker, PhD
Congratulations to our Markesbery Symposium Scientific Session winners!
@ukresearch.bsky.social
@ukresearch.bsky.social
November 10, 2025 at 7:58 PM
Congratulations to our Markesbery Symposium Scientific Session winners!
@ukresearch.bsky.social
@ukresearch.bsky.social
Reposted by Colton Lysaker, PhD
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1
September 7, 2025 at 12:40 PM
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Reposted by Colton Lysaker, PhD
Are you an ATP!?!
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
August 18, 2025 at 8:45 PM
Are you an ATP!?!
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).
Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.
Apply here! rb.gy/3zk4cm
Reposted by Colton Lysaker, PhD
BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Senator Murray Slams Trump Admin for Choking Off Lifesaving NIH Medical Research - Senator Patty Murray
Washington, D.C. – Today, U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee, issued the following statement on reports today that President Trump’s Office of Manageme...
www.murray.senate.gov
July 30, 2025 at 2:50 AM
BREAKING: Trump wants to illegally cut off $15 billion in lifesaving NIH research.
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Research to cure cancer, Alzheimer's, and so much more is on the line.
These people are LYING about waste, fraud, and abuse at NIH to justify attacking medical research—we all need to say so.
My full statement. ⬇️
Reposted by Colton Lysaker, PhD
#Breaking: Trump administration blocks NIH from awarding any research grants and contracts
www.statnews.com/2025/07/29/t...
www.statnews.com/2025/07/29/t...
Trump administration blocks NIH from awarding any research grants and contracts
The order applies to the entirety of new and, possibly, ongoing research grant dollars that go to universities and academic medical centers.
www.statnews.com
July 30, 2025 at 1:26 AM
#Breaking: Trump administration blocks NIH from awarding any research grants and contracts
www.statnews.com/2025/07/29/t...
www.statnews.com/2025/07/29/t...
Reposted by Colton Lysaker, PhD
A study in Nature Metabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. go.nature.com/44T8kct 🧪
July 10, 2025 at 10:45 PM
A study in Nature Metabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. go.nature.com/44T8kct 🧪
Reposted by Colton Lysaker, PhD
New pre-print out:
www.biorxiv.org/content/10.1...
Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures
Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
www.biorxiv.org/content/10.1...
Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures
Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease
Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-dr...
www.biorxiv.org
May 16, 2025 at 5:49 PM
New pre-print out:
www.biorxiv.org/content/10.1...
Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures
Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
www.biorxiv.org/content/10.1...
Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures
Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
My first, first author publication is out now in @jphysiol.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...
A polygenetic rat model of divergent aerobic capacity reveals a liver–brain interaction impacting Alzheimer's disease‐like phenotypes
Abstract figure legend This study examined the effects of aerobic capacity diet, and sex on brain and liver health in the context of the Alzheimer's disease (AD) biomarker amyloid beta (Aβ42). The da....
physoc.onlinelibrary.wiley.com
May 19, 2025 at 2:04 AM
My first, first author publication is out now in @jphysiol.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Colton Lysaker, PhD
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
@cancelluio.bsky.social @arcticautophagy.bsky.social
@cancelluio.bsky.social @arcticautophagy.bsky.social
March 7, 2025 at 6:12 PM
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
@cancelluio.bsky.social @arcticautophagy.bsky.social
@cancelluio.bsky.social @arcticautophagy.bsky.social
Reposted by Colton Lysaker, PhD
“We can look to venom, surprisingly, to aid us biomedically," says Dr. Barrett Klein. "For example, bee venom therapy has been used for arthritis, arthralgia, Parkinson’s, ALS, multiple sclerosis, and other conditions.”
How Insects Changed The World—And Human Cultures
In “The Insect Epiphany,” an entomologist explores the history of insects in art, food, engineering, and more.
buff.ly
February 16, 2025 at 3:15 PM
“We can look to venom, surprisingly, to aid us biomedically," says Dr. Barrett Klein. "For example, bee venom therapy has been used for arthritis, arthralgia, Parkinson’s, ALS, multiple sclerosis, and other conditions.”