GenomeMapper!!!

2/2 Our lab pioneered the use of genome graphs already 16 years ago! Read this oldie-but-goldie from @labschneeberger.bsky.social and Jörg Hagmann: Simultaneous alignment of short reads against multiple genomes
genomebiology.biomedcentral.com/articles/10....

~47 min mark of music.youtube.com/watch?v=uiQp...
Similar prognosis/sentiment

Many congratulations Wenfei!!!

www.sciencedirect.com/science/arti...
We: Luisa, @kdm9.bsky.social, Max, @aconga.bsky.social , Theresa, Leon, Justina, Christa, Oliver, Regina, Rosanne, @hajkdrost.bsky.social , @plantevolution.bsky.social , @coevolution.bsky.social

..... these alleles have arrived there following many ways and will continue their evolutionary journey in natural pathosystems. This research was intellectually stimulating and rewarding experience for all of us. Check it out in @cp-cellhostmicrobe.bsky.social latest issue........

.....through transposable elements along the way. 'hoods allowed us to look beyond traditional definitions of NLR clusters and their patterns of evolution. Context made us realize that NLRs are remarkable in their diversity even more than previously thought. When we study NLRs in the lab....

.....curated the NLRs with help of a computational pipeline. Meanwhile, the development of PGGB @thinks.lol and ODGI @andreaguarracino.bsky.social made us wander into the land of graphs and use network theory to propose concept of "pangenomic NLR neighborhoods". We also navigated.....

Feel free to ask any q's here

We show that pangenome graphs provide a flexible way to define the context within which NLR evolution occurs, and that graph metrics capture diversity in both sequence and structure, and show that such diversity is centered on NLRs themselves

Long story short: we assemble 17 representative Arabidopsis thaliana genomes, exhaustively annotate NLRs with long read evidence & manual curation, and assay many measures of NLR diversity.

More #bloomscrolling from the Smokies