Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood

There's much more in the preprint - a great team effort from @clairecoffey.bsky.social @sritchie73.bsky.social, Lisa Pennells, Angela Wood & @mikeinouye.bsky.social all from @cambridge-ceu.bsky.social!

Clinical statements (AHA, ESC) have suggested that PRS may be most useful as a risk-enhancing factor for those at intermediate risk. We used PRS to reclassify individuals at intermediate risk by QRISK3 and showed improved sensitivity and fairness benefits (particularly for age & sex).

We evaluated PRS in two contexts, as a standalone risk predictor and as a risk-enhancing factor. Given the known performance differences across ancestries, we were surprised to find that the fairness of PRS predictions across ethnicities was equal to or lower other CVD risk factors when used alone.

Thank you!

Thank you to HDR UK, @wellcometrust.bsky.social, and The Alan Turing Institute for funding and delivering my PhD programme, and to @dphpc.bsky.social, @vpd-hlri.bsky.social, @cambridgeuni.bsky.social for being my home over the past years!

Thanks Mike 😆!

Thanks Mike! 😄

Thank you @charlottesummers.bsky.social !

Thank you to all the workshop participants and collaborators involved! Special thanks to Lekkaa Rambabu and the International Health Systems group at @eng.cam.ac.uk for getting me involved and making this all happen! 😊

The report "Equitable, trustworthy and safe research in healthcare technology, data and artificial intelligence: an international dialogue" provides 5 key priorities for researchers: trust, governance, reliability, access, and equity ⭐️