Bernasconi-Bisio, Pineda-Lucena and colleagues established an integrative SdAb platform for CAR-T cell development addressing limitations of a conventional ScFv-based CAR against CD33 for AML targeting. SdAb-based CARs overcome challenges like tonic…

The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

Westhaus and colleagues developed a new bioengineering platform that allows identification of novel AAV variants that enhance gene editing applications and have validated the platform in human T cells. The new ‘recombinogenic’ AAV variants improve the efficiency of on-target editing and lead to the generation of highly functional CAR T-cells.

Abstract. Patients treated with chimeric antigen receptor T-cell (CAR-T) therapy are subject to profound immune suppression. Dynamics of immune reconstitution (IR) and impacts of IR on outcomes follow...

Orna Therapeutics showcased groundbreaking data at ASH 2024, highlighting its panCAR™ platform's effectiveness in delivering RNA for B cell-mediated diseases, promising new treatment pathways.

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Nature - Engineered receptors for soluble cellular communication and disease sensing