Ciara Pugh
@ciarapugh.bsky.social
irish | membrane protein enthusiast @ ucph | she/her
Reposted by Ciara Pugh
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
July 28, 2025 at 9:31 PM
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
Reposted by Ciara Pugh
💖💛💖💛💖 BEN IN YELLOW !!! The Irishman takes the leader’s jersey on stage 10 after an insane ride from Healy and the squad 🥹
📸: Getty Images
#TDF2025
📸: Getty Images
#TDF2025
July 14, 2025 at 3:53 PM
💖💛💖💛💖 BEN IN YELLOW !!! The Irishman takes the leader’s jersey on stage 10 after an insane ride from Healy and the squad 🥹
📸: Getty Images
#TDF2025
📸: Getty Images
#TDF2025
Reposted by Ciara Pugh
So proud of my PhD student @ciarapugh.bsky.social for delivering a brilliant flash talk at the @isbuc.bsky.social #CSSB25 seminar today! She shared our latest work on our native nanodisc-forming copolymer MAASTY and absolutely nailed it.
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!
Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology
June 12, 2025 at 9:17 PM
So proud of my PhD student @ciarapugh.bsky.social for delivering a brilliant flash talk at the @isbuc.bsky.social #CSSB25 seminar today! She shared our latest work on our native nanodisc-forming copolymer MAASTY and absolutely nailed it.
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!
Reposted by Ciara Pugh
Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology
June 12, 2025 at 3:27 PM
Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology
Reposted by Ciara Pugh
Reposted by Ciara Pugh
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
www.nature.com
November 27, 2024 at 8:31 PM
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ciara Pugh
The most stressed out I've ever been about Christmas was when I was 16 and I got my first ever job, working at M&S in Dundrum. As soon as I started I kept hearing these myths about the Christmas Eve Waste Sale, where all the food that wasn't sold on the 24th was marked down 90%.
November 27, 2023 at 1:17 PM
The most stressed out I've ever been about Christmas was when I was 16 and I got my first ever job, working at M&S in Dundrum. As soon as I started I kept hearing these myths about the Christmas Eve Waste Sale, where all the food that wasn't sold on the 24th was marked down 90%.
Reposted by Ciara Pugh
This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
cryoEM papers (@cryoempapers.bsky.social)
Operated by @shervinnia.bsky.social and inspired by the now-defunct bot by Frédéric Poitevin and @gati.bsky.social. Suggestions welcome.
cryoempapers.bsky.social
November 20, 2024 at 3:54 PM
This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social