🎁 Early Xmas present from your friends at the MRC-University of Glasgow Centre for Virus Research @cvrinfo.bsky.social

We're thrilled to unwrap Viro3D - a comprehensive database of virus protein structures: >85,000 predicted structures from 4,400 human & animal viruses! 🦠

viro3d.cvr.gla.ac.uk

Excited to finally share Perceptein, a PERCEPtron made of proTEINs: www.science.org/doi/10.1126/...

Out today, our newest paper in Nature Cardiovascular Research! A Herculean effort by an amazing grad student Joanna Wong. In short, we demonstrate pulmonary veins sprout and differentiate into capillary cells after severe lung injury. www.nature.com/articles/s44...

How did I miss this preprint, posted in June?
Looks really intersting.
They suggest transfer of mRNA, ribosomes & translating ribosomes through #TunnelingNanotubes in pancreatic cancer, promoted by chemo.
Added to the reading pile.
#RNASky #RNABiology #Cytoskel 🧪🔬

www.biorxiv.org/content/10.1...

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras

Complete with collective nouns

I’ve been tracking these but now can’t keep up

Hope it’s helpful

2/2

docs.google.com/spreadsheets...

In @science.org this week, Simic, Watchmaker, Zamvil, Okada, and Lim engineer #TCells specific for #CNS #ECM antigens to deliver payloads selectively to the #brain!

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Can LLMs predict RNA structures? 🧬 🧪

ViraLM: Empowering Virus Discovery through the Genome Foundation Model https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btae704/7907584?rss=1 🧬🖥️🧪 https://github.com/ChengPENG-wolf/ViraLM

Pylustrator offers an interactive interface to find the best way to present your data in a figure for publication. Added formatting and styling can be saved by automatically generated code. https://pylustrator.readthedocs.io/en/latest/ #python

A cancer immunotherapy modality based on dendritic cell reprogramming in vivo https://www.biorxiv.org/content/10.1101/2024.07.08.602356v1

Cells transit through a quiescent-like state to convert to neurons at high rates https://www.biorxiv.org/content/10.1101/2024.11.22.624928v1

What can cloud computing bring to the discovery of novel EVEs in vertebrate genomes? Rather a lot, really happy to share this work with Jose Gabriel:

rdcu.be/dXF4A

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...

Hot off the pre-press! Unbiased selection of alphacoronavirus 🦠 spikes plus pseudotype entry assays with 25+ receptors (🦇🐈🐶🐒🚶‍♀️...). Receptor host range can vary dramatically between closely-related viruses, plus many alphaCoVs don't seem to use known receptors at all:
www.biorxiv.org/content/10.1...