Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
@christosargyrop.bsky.social
Division Chief, Nephrology UNMHSC
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
Forget JSON, TOON, and VSC! The VST (Values Separated by Tabs), retains all the advantages of the VSC but brings the Pythonic esthetics to the table; a format that was stolen from the LLM gods and gifted to humans by the Prometheus (PROMpting the ETHEr for sUbStance) of the human founder spirit.
November 17, 2025 at 11:32 PM
Forget JSON, TOON, and VSC! The VST (Values Separated by Tabs), retains all the advantages of the VSC but brings the Pythonic esthetics to the table; a format that was stolen from the LLM gods and gifted to humans by the Prometheus (PROMpting the ETHEr for sUbStance) of the human founder spirit.
I am very comfortable stating that DISA-STIG RHEL has been the largest humblepie I have had to eat in my life so far (and I am still half way through it)
November 17, 2025 at 5:06 PM
I am very comfortable stating that DISA-STIG RHEL has been the largest humblepie I have had to eat in my life so far (and I am still half way through it)
I loved this piece
👀#Perl is a messy, maddening programming language, the “duct tape of the internet.”
✊But at least you can tell it was made by humans.
🙏Still, I find myself returning to this strange language, and I think it’s because of the humility at its core.
www.wired.com/story/progra...
👀#Perl is a messy, maddening programming language, the “duct tape of the internet.”
✊But at least you can tell it was made by humans.
🙏Still, I find myself returning to this strange language, and I think it’s because of the humility at its core.
www.wired.com/story/progra...
Programmers Aren’t So Humble Anymore—Maybe Because Nobody Codes in Perl
Perl is a messy, maddening programming language, the “duct tape of the internet.” But at least you can tell it was made by humans.
www.wired.com
November 15, 2025 at 10:21 AM
I loved this piece
👀#Perl is a messy, maddening programming language, the “duct tape of the internet.”
✊But at least you can tell it was made by humans.
🙏Still, I find myself returning to this strange language, and I think it’s because of the humility at its core.
www.wired.com/story/progra...
👀#Perl is a messy, maddening programming language, the “duct tape of the internet.”
✊But at least you can tell it was made by humans.
🙏Still, I find myself returning to this strange language, and I think it’s because of the humility at its core.
www.wired.com/story/progra...
Herd immunity : not just for humans.
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
November 14, 2025 at 2:22 PM
Herd immunity : not just for humans.
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
A reminder of the amazing work of Willem Kolff
November 13, 2025 at 9:18 PM
A reminder of the amazing work of Willem Kolff
In the work room of one of our dialysis clinics....
November 13, 2025 at 8:35 PM
In the work room of one of our dialysis clinics....
Personal experience (your mileage may vary): reactogenic side effects of mNEXSPIKE is between Nuvaxovid (least) and COMIRNATY / SPIKEVAX (more/most).
November 12, 2025 at 3:18 PM
Personal experience (your mileage may vary): reactogenic side effects of mNEXSPIKE is between Nuvaxovid (least) and COMIRNATY / SPIKEVAX (more/most).
Lol, this #vibecoding advice is solid
November 12, 2025 at 9:51 AM
Lol, this #vibecoding advice is solid
Based and I would not mind the nuclear Renaissance that hopefully will be funded before AI croaks
November 11, 2025 at 4:17 PM
Based and I would not mind the nuclear Renaissance that hopefully will be funded before AI croaks
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Food should provide pleasure. This lunch is an abomination.
November 11, 2025 at 12:40 AM
Food should provide pleasure. This lunch is an abomination.
Grab popcorn as the premiums of the individual healthcare plans for 2026 are announced. Looking at the number of layoffs and the age distribution of those being laid off, many more people will have to transition from an employer to a pricey individual plan during the midterms.
November 10, 2025 at 6:07 PM
Grab popcorn as the premiums of the individual healthcare plans for 2026 are announced. Looking at the number of layoffs and the age distribution of those being laid off, many more people will have to transition from an employer to a pricey individual plan during the midterms.
Paneer and queso Blanco are edible and don't have the texture of goat poop.
Disagree and why single out cottage cheese? Are you saying that paneer, queso blanco, etc. are also "kale of milk"? Unless you are anti acid and only pro-rennet. What about ricotta, is it OK because of whey and heat?
November 10, 2025 at 4:14 PM
Paneer and queso Blanco are edible and don't have the texture of goat poop.
Cottage cheese = kale of milk derivatives
Now you know
Now you know
November 10, 2025 at 2:59 PM
Cottage cheese = kale of milk derivatives
Now you know
Now you know
This is where it gets interesting : at a word size of 1 bit, multiplication is just logical and. So is all multiplication just logical conjunction? First principle derivation of probability as degrees of certainty rely precisely on this connection
@stephensenn.bsky.social @cubiclogic.bsky.social
@stephensenn.bsky.social @cubiclogic.bsky.social
November 10, 2025 at 2:59 PM
This is where it gets interesting : at a word size of 1 bit, multiplication is just logical and. So is all multiplication just logical conjunction? First principle derivation of probability as degrees of certainty rely precisely on this connection
@stephensenn.bsky.social @cubiclogic.bsky.social
@stephensenn.bsky.social @cubiclogic.bsky.social
Incretins are the G-force : Guardians of (Inner) Space(*).
No more glipination @hswapnil.medsky.social @mikejohansenmd.medsky.social @rnflex.bsky.social,only G force
(*)a reference to the 1980s US adaptation of the 1972 Japanese anime Gatchaman but feel free to substitute the 2009 guinea pig movie
No more glipination @hswapnil.medsky.social @mikejohansenmd.medsky.social @rnflex.bsky.social,only G force
(*)a reference to the 1980s US adaptation of the 1972 Japanese anime Gatchaman but feel free to substitute the 2009 guinea pig movie
November 10, 2025 at 2:44 PM
Incretins are the G-force : Guardians of (Inner) Space(*).
No more glipination @hswapnil.medsky.social @mikejohansenmd.medsky.social @rnflex.bsky.social,only G force
(*)a reference to the 1980s US adaptation of the 1972 Japanese anime Gatchaman but feel free to substitute the 2009 guinea pig movie
No more glipination @hswapnil.medsky.social @mikejohansenmd.medsky.social @rnflex.bsky.social,only G force
(*)a reference to the 1980s US adaptation of the 1972 Japanese anime Gatchaman but feel free to substitute the 2009 guinea pig movie
Packing Costco lunch because inflation, weight loss and intermittent fasting (which is just caloric restriction)
November 10, 2025 at 2:33 PM
Packing Costco lunch because inflation, weight loss and intermittent fasting (which is just caloric restriction)
As one of the original flozinators it so maddening to see nephrologists flozinate *instead* of using immunosuppresants, dz modifying therapies in nonDM CKD. Consider a thought experiment in transplant: proteinuria is often how we pick up ABMR & an SGLT2i is the wrong answer. Now do IgAN, SLE,C3G etc
November 10, 2025 at 2:18 PM
As one of the original flozinators it so maddening to see nephrologists flozinate *instead* of using immunosuppresants, dz modifying therapies in nonDM CKD. Consider a thought experiment in transplant: proteinuria is often how we pick up ABMR & an SGLT2i is the wrong answer. Now do IgAN, SLE,C3G etc
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Typhoon Kalmaegi exposes centuries-old shipwreck off Vietnam port ⛏️⚓️🇻🇳 www.channelnewsasia.com/asia/typhoon...
Typhoon Kalmaegi exposes centuries-old shipwreck off Vietnam port
HOI AN: Severe coastal erosion caused by Typhoon Kalmaegi exposed a centuries-old shipwreck in Vietnam, providing a narrow window to salvage what experts say could be a historically significant find.I...
www.channelnewsasia.com
November 10, 2025 at 12:41 PM
Typhoon Kalmaegi exposes centuries-old shipwreck off Vietnam port ⛏️⚓️🇻🇳 www.channelnewsasia.com/asia/typhoon...
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
What are the pharmacodynamics of loop diuretics?
A recent editorial was entitled ‘Loop diuretics in heart failure: few facts and lots of prejudice’.1 I would argue that we have forgotten or distorted some
academic.oup.com
November 9, 2025 at 6:40 PM
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
Nailed it
November 10, 2025 at 1:25 AM
Nailed it
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Bahahahahaha The New York Times just printed an opinion piece declaring "AI is intelligent, so long as we redefine what intelligence means to include it. And soon AI will be conscious, because we'll just redefine consciousness too!"
Nothing means anything! Yay!
www.nytimes.com/2025/11/08/o...
Nothing means anything! Yay!
www.nytimes.com/2025/11/08/o...
Opinion | A.I. Is on Its Way to Something Even More Remarkable Than Intelligence
www.nytimes.com
November 9, 2025 at 3:02 PM
Bahahahahaha The New York Times just printed an opinion piece declaring "AI is intelligent, so long as we redefine what intelligence means to include it. And soon AI will be conscious, because we'll just redefine consciousness too!"
Nothing means anything! Yay!
www.nytimes.com/2025/11/08/o...
Nothing means anything! Yay!
www.nytimes.com/2025/11/08/o...