Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
@christosargyrop.bsky.social
Division Chief, Nephrology UNMHSC
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
Herd immunity : not just for humans.
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
November 14, 2025 at 2:22 PM
Herd immunity : not just for humans.
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
Your IT security team could be preventing your computer from becoming impervious to cyber-threats. Delete your antivirus!
In the work room of one of our dialysis clinics....
November 13, 2025 at 8:35 PM
In the work room of one of our dialysis clinics....
Lol, this #vibecoding advice is solid
November 12, 2025 at 9:51 AM
Lol, this #vibecoding advice is solid
Based and I would not mind the nuclear Renaissance that hopefully will be funded before AI croaks
November 11, 2025 at 4:17 PM
Based and I would not mind the nuclear Renaissance that hopefully will be funded before AI croaks
This is where it gets interesting : at a word size of 1 bit, multiplication is just logical and. So is all multiplication just logical conjunction? First principle derivation of probability as degrees of certainty rely precisely on this connection
@stephensenn.bsky.social @cubiclogic.bsky.social
@stephensenn.bsky.social @cubiclogic.bsky.social
November 10, 2025 at 2:59 PM
This is where it gets interesting : at a word size of 1 bit, multiplication is just logical and. So is all multiplication just logical conjunction? First principle derivation of probability as degrees of certainty rely precisely on this connection
@stephensenn.bsky.social @cubiclogic.bsky.social
@stephensenn.bsky.social @cubiclogic.bsky.social
Packing Costco lunch because inflation, weight loss and intermittent fasting (which is just caloric restriction)
November 10, 2025 at 2:33 PM
Packing Costco lunch because inflation, weight loss and intermittent fasting (which is just caloric restriction)
Nailed it
November 10, 2025 at 1:25 AM
Nailed it
Lord, have mercy
November 7, 2025 at 5:57 PM
Lord, have mercy
Until next year leaves (but at this stage, every leaf is a flower as a philosopher one said)
November 7, 2025 at 3:27 PM
Until next year leaves (but at this stage, every leaf is a flower as a philosopher one said)
Perfect example of an LLM output of coherent parts (sentences) summing up to an incoherent whole (paragraph).
Imagine this playing out at a larger scales by those who have adopted these noisy stochastic parrots at scale.
Imagine this playing out at a larger scales by those who have adopted these noisy stochastic parrots at scale.
November 7, 2025 at 1:39 PM
Perfect example of an LLM output of coherent parts (sentences) summing up to an incoherent whole (paragraph).
Imagine this playing out at a larger scales by those who have adopted these noisy stochastic parrots at scale.
Imagine this playing out at a larger scales by those who have adopted these noisy stochastic parrots at scale.
It is insane, that #Intel kneecapped i7's for scientific work. The 11th gen i7 offered the AVX512 instruction set which DOUBLED throughput compared to the 10th 7 the 12th gen. To get the same throughput that this i7 delivers in our RNAseq workflows, one has to pay $$$ for a Xeon
November 5, 2025 at 1:45 AM
It is insane, that #Intel kneecapped i7's for scientific work. The 11th gen i7 offered the AVX512 instruction set which DOUBLED throughput compared to the 10th 7 the 12th gen. To get the same throughput that this i7 delivers in our RNAseq workflows, one has to pay $$$ for a Xeon
I feel seen
November 4, 2025 at 11:10 PM
I feel seen
I have working examples of the #Perl + SIMDe marriage for the extreme portability aspect but also for quick performance tuning!
See also this paper about accelerating migration fron x86 ARM NEON and RISCV
arxiv.org/abs/2309.16509
See also this paper about accelerating migration fron x86 ARM NEON and RISCV
arxiv.org/abs/2309.16509
November 3, 2025 at 4:46 PM
I have working examples of the #Perl + SIMDe marriage for the extreme portability aspect but also for quick performance tuning!
See also this paper about accelerating migration fron x86 ARM NEON and RISCV
arxiv.org/abs/2309.16509
See also this paper about accelerating migration fron x86 ARM NEON and RISCV
arxiv.org/abs/2309.16509
When my 14 y/o Twitter account was banned in 2024 after a hack, I lost all #meded posts. But in #slideshare, I found my 2017 presentation, the year after I started my off-label use of #sglt2i in kidney disease. I'm glad I got most things right back then
www.slideshare.net/chrisarg/sgl...
www.slideshare.net/chrisarg/sgl...
November 1, 2025 at 5:37 PM
When my 14 y/o Twitter account was banned in 2024 after a hack, I lost all #meded posts. But in #slideshare, I found my 2017 presentation, the year after I started my off-label use of #sglt2i in kidney disease. I'm glad I got most things right back then
www.slideshare.net/chrisarg/sgl...
www.slideshare.net/chrisarg/sgl...
Can you guess what the fistulogram showed when the fistula (bruit in left) was sent for angiography?
The PCG on the right (different patient) is also telling. The Eko rocks
The PCG on the right (different patient) is also telling. The Eko rocks
November 1, 2025 at 2:22 PM
Can you guess what the fistulogram showed when the fistula (bruit in left) was sent for angiography?
The PCG on the right (different patient) is also telling. The Eko rocks
The PCG on the right (different patient) is also telling. The Eko rocks
The price of freedom
October 27, 2025 at 11:35 AM
The price of freedom
The shrimp as a metaphor
October 25, 2025 at 9:17 PM
The shrimp as a metaphor
My most successful Perl modules pass the tests with flying colors
October 23, 2025 at 8:45 PM
My most successful Perl modules pass the tests with flying colors
The Odyssey - magnesium citrate version
October 23, 2025 at 6:31 PM
The Odyssey - magnesium citrate version
So true - as someone who has to physically show up to work most of the time, I wish you could all stay at home.
October 23, 2025 at 1:24 AM
So true - as someone who has to physically show up to work most of the time, I wish you could all stay at home.
@mikejohansenmd.medsky.social and myself said "class effect" 5 years ago when we put together a meta-analysis during the lockdowns
pmc.ncbi.nlm.nih.gov/articles/PMC...
My view of the economics of the #sglt2i from 4 years ago - worth considering the cost figure
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
My view of the economics of the #sglt2i from 4 years ago - worth considering the cost figure
pmc.ncbi.nlm.nih.gov/articles/PMC...
October 21, 2025 at 10:38 PM
@mikejohansenmd.medsky.social and myself said "class effect" 5 years ago when we put together a meta-analysis during the lockdowns
pmc.ncbi.nlm.nih.gov/articles/PMC...
My view of the economics of the #sglt2i from 4 years ago - worth considering the cost figure
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
My view of the economics of the #sglt2i from 4 years ago - worth considering the cost figure
pmc.ncbi.nlm.nih.gov/articles/PMC...