Christopher Frank
@chrisfrank662.bsky.social
De novo Protein Designer
DNA Origami wizzard
I like lifting rocks
PhD student
@TU_Muenchen
DNA Origami wizzard
I like lifting rocks
PhD student
@TU_Muenchen
Reposted by Christopher Frank
Cant wait for the first tests 🚀
February 20, 2025 at 4:22 PM
Cant wait for the first tests 🚀
This is awesome! Great work! 🔥
New protein ML preprint from my PhD project.
We describe salad (sparse all-atom denoising), a family of efficient protein structure diffusion models and show that it works well on a bunch of protein design task previously described in the literature.
Preprint: www.biorxiv.org/content/10.1...
(1/N)
We describe salad (sparse all-atom denoising), a family of efficient protein structure diffusion models and show that it works well on a bunch of protein design task previously described in the literature.
Preprint: www.biorxiv.org/content/10.1...
(1/N)
February 7, 2025 at 7:06 AM
This is awesome! Great work! 🔥
This www.biorxiv.org/content/10.1...
Is so, so, so damn important work! 🔥
The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations.
Time that we start "designing the un-Designable" 😆
Is so, so, so damn important work! 🔥
The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations.
Time that we start "designing the un-Designable" 😆
www.biorxiv.org
January 16, 2025 at 7:54 AM
This www.biorxiv.org/content/10.1...
Is so, so, so damn important work! 🔥
The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations.
Time that we start "designing the un-Designable" 😆
Is so, so, so damn important work! 🔥
The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations.
Time that we start "designing the un-Designable" 😆
Crosspost from X: After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton.org @hendrikdietz.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Alphafold2 refinement improves designability of large de novo proteins
Recent advances in computational protein design have enabled the creation of novel proteins for a variety of purposes. The capability for producing custom-shape high-quality backbones for very large p...
www.biorxiv.org
November 22, 2024 at 12:47 PM
Crosspost from X: After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton.org @hendrikdietz.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Christopher Frank
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!