Christophe BELOIN
@chrisbel70.bsky.social
Group Leader in Genetics of Biofilms Unit, Institut Pasteur, I aim at understanding biofilm-related infections as well as studying the amazing Diderm Firmicutes
Reposted by Christophe BELOIN
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
September 5, 2025 at 1:49 PM
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Reposted by Christophe BELOIN
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
www.biorxiv.org
September 10, 2025 at 8:17 AM
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Reposted by Christophe BELOIN
And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣
April 8, 2025 at 4:59 AM
And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣
Reposted by Christophe BELOIN
Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...
Phage therapy for Klebsiella pneumoniae: Understanding bacteria–phage interactions for therapeutic innovations
Klebsiella pneumoniae (KP) is a Gram-negative bacterium that commonly resides in the human gastrointestinal tract and can also act as an opportunistic pathogen and cause extra-intestinal infections. K...
doi.org
April 9, 2025 at 10:10 AM
Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...
Reposted by Christophe BELOIN
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
'
my.corehr.com
February 22, 2025 at 8:07 PM
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
Reposted by Christophe BELOIN
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
March 12, 2025 at 12:36 PM
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
Reposted by Christophe BELOIN
👩🔬 On this #WomenInScience Day 2025, we celebrate the inspiring female scientists at Institut Pasteur! More than researchers, they make science accessible to all. 🌍✨
Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...
Let’s continue to amplify their voices 🚀
Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...
Let’s continue to amplify their voices 🚀
Women scientists: inspiring faces of research at the Institut Pasteur
The International Day of Women and Girls in Science 2025 is an opportunity to shine the spotlight on committed and talented women researchers. In addition to their scientific work, these Institut Past...
www.pasteur.fr
February 11, 2025 at 9:43 AM
👩🔬 On this #WomenInScience Day 2025, we celebrate the inspiring female scientists at Institut Pasteur! More than researchers, they make science accessible to all. 🌍✨
Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...
Let’s continue to amplify their voices 🚀
Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...
Let’s continue to amplify their voices 🚀
Reposted by Christophe BELOIN
Reposted by Christophe BELOIN
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
January 28, 2025 at 3:58 AM
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
Reposted by Christophe BELOIN
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
January 14, 2025 at 9:10 AM
Welcome to the official Bluesky page of the Institut Pasteur!
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
🔬 Explore with us the frontiers of biomedical research
🧪 Follow us to uncover groundbreaking discoveries
💡 Share knowledge for global health
🌍 Join a community passionate about progress and open science.
Reposted by Christophe BELOIN
Vaccines save lives.
December 29, 2024 at 9:53 PM
Vaccines save lives.
Reposted by Christophe BELOIN
We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...
Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur
research.pasteur.fr
December 8, 2024 at 3:04 PM
We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...
Reposted by Christophe BELOIN
2 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky!
Please repost: Nov. 15 deadline! We are building a strong bacteriology community at Univ de Montréal, including recent hires Sven van Teeffelen, Frédérique Le Roux & myself. Moving to Montréal in 2018 is one of the best career decisions I made. Come join us! jobs.sciencecareers.org/job/664282/a...
Assistant or Associate Professor in Bacteriology - Montréal, Quebec (CA) job with University of Montreal | 664282
Université de Montréal (UdeM) is looking for an Assistant or Associate full-time professor in the field of bacteriology.
jobs.sciencecareers.org
November 13, 2024 at 7:18 AM
2 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky!
Our last story is in mBio !(tinyurl.com/h83mh8vy).
Oral bacteria often form mixed species biofilms where aggregation drives interspecies interactions.
Here we investigated Veillonella parvula aggregation with other bacteria and identified molecular actors at the base of such specific interactions!
Oral bacteria often form mixed species biofilms where aggregation drives interspecies interactions.
Here we investigated Veillonella parvula aggregation with other bacteria and identified molecular actors at the base of such specific interactions!
Identification of Veillonella parvula and Streptococcus gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure | mBio
Our research explores the mechanisms of bacterial adhesion within the dental plaque,
focusing on Veillonella parvula, a key player in the oral microbiome. Dependent on lactate from streptococci, V. pa...
tinyurl.com
November 12, 2024 at 6:15 PM
Our last story is in mBio !(tinyurl.com/h83mh8vy).
Oral bacteria often form mixed species biofilms where aggregation drives interspecies interactions.
Here we investigated Veillonella parvula aggregation with other bacteria and identified molecular actors at the base of such specific interactions!
Oral bacteria often form mixed species biofilms where aggregation drives interspecies interactions.
Here we investigated Veillonella parvula aggregation with other bacteria and identified molecular actors at the base of such specific interactions!
Reposted by Christophe BELOIN
Diderm Firmicutes strike again! "The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking"
Another beautiful story on the bacterial envelope with @chrisbel70.bsky.social @jmghigolab.bsky.social out today! rdcu.be/drNQ3 #MicroSky
Another beautiful story on the bacterial envelope with @chrisbel70.bsky.social @jmghigolab.bsky.social out today! rdcu.be/drNQ3 #MicroSky
November 23, 2023 at 8:46 AM
Diderm Firmicutes strike again! "The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking"
Another beautiful story on the bacterial envelope with @chrisbel70.bsky.social @jmghigolab.bsky.social out today! rdcu.be/drNQ3 #MicroSky
Another beautiful story on the bacterial envelope with @chrisbel70.bsky.social @jmghigolab.bsky.social out today! rdcu.be/drNQ3 #MicroSky
Our story on the Maintenance of Lipid Asymmetry (Mla) system in the amazing Veillonella parvula and in the whole bacterial diversity it now out in Nature Communications.
Check it out!
rdcu.be/drNQ3.
#bacterial cell envelope
@sgribaldo.bsky.social @jmghigolab.bsky.social
Check it out!
rdcu.be/drNQ3.
#bacterial cell envelope
@sgribaldo.bsky.social @jmghigolab.bsky.social
November 23, 2023 at 8:28 AM
Our story on the Maintenance of Lipid Asymmetry (Mla) system in the amazing Veillonella parvula and in the whole bacterial diversity it now out in Nature Communications.
Check it out!
rdcu.be/drNQ3.
#bacterial cell envelope
@sgribaldo.bsky.social @jmghigolab.bsky.social
Check it out!
rdcu.be/drNQ3.
#bacterial cell envelope
@sgribaldo.bsky.social @jmghigolab.bsky.social
Reposted by Christophe BELOIN
Our paper on structural and functional characterisation of OmpM, the predominant outer membrane tethering system in Terrabacteria, is now out!
Great collaboration between @sgribaldo.bsky.social Christophe Beloin @sykhalid.bsky.social and Bert van den Berg groups.
www.nature.com/articles/s41...
Great collaboration between @sgribaldo.bsky.social Christophe Beloin @sykhalid.bsky.social and Bert van den Berg groups.
www.nature.com/articles/s41...
Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes - Na...
Outer membrane tethering is important for cell envelope integrity in diderm bacteria. Here, the authors present structures and functional analyses of the stalked porin OmpM, which is the main outer me...
www.nature.com
November 7, 2023 at 11:52 AM
Our paper on structural and functional characterisation of OmpM, the predominant outer membrane tethering system in Terrabacteria, is now out!
Great collaboration between @sgribaldo.bsky.social Christophe Beloin @sykhalid.bsky.social and Bert van den Berg groups.
www.nature.com/articles/s41...
Great collaboration between @sgribaldo.bsky.social Christophe Beloin @sykhalid.bsky.social and Bert van den Berg groups.
www.nature.com/articles/s41...
Reposted by Christophe BELOIN
Iron-Sulfur clusters are essential protein co-factors in eukaryotes and are synthesized in mitochondria and plastids by ISC and SUF systems. Can we use these machineries to investigate the origins of organelles? Happy to share our short report out today! #MicroSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Components of iron–Sulfur cluster assembly machineries are robust phylogenetic markers to trace th...
The symbioses that gave rise to primary organelles are key events in the origin of Eukaryotes. This study uses a dataset of markers belonging to two conserved machineries responsible for [Fe-S] cluste...
journals.plos.org
November 9, 2023 at 10:09 AM
Iron-Sulfur clusters are essential protein co-factors in eukaryotes and are synthesized in mitochondria and plastids by ISC and SUF systems. Can we use these machineries to investigate the origins of organelles? Happy to share our short report out today! #MicroSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...