Charles Yeh
@charlesyeh.bsky.social
Reposted by Charles Yeh
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop b...
www.biorxiv.org
February 13, 2025 at 1:16 AM
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Reposted by Charles Yeh
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
February 12, 2025 at 5:15 PM
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
Reposted by Charles Yeh
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
February 12, 2025 at 4:00 PM
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...