CEStieger.bsky.social
@cestieger.bsky.social
🇦🇹 Chemist with a passion for phosphorus and chemical proteomics
PhD @Hackenberger lab, FMP Berlin 🇩🇪
Now: PostDoc @Nomura lab, UC Berkeley 🇺🇸
PhD @Hackenberger lab, FMP Berlin 🇩🇪
Now: PostDoc @Nomura lab, UC Berkeley 🇺🇸
🎉 Excited to share the first bioRxiv & medRxiv preprint from my PostDoc.
It’s been — and continues to be — an incredible journey into the world of epigenetics, exploring how we can reprogram oncogenic transcription factor activity using chemical inducers of proximity.
👨🔬🧪🧬🧫
It’s been — and continues to be — an incredible journey into the world of epigenetics, exploring how we can reprogram oncogenic transcription factor activity using chemical inducers of proximity.
👨🔬🧪🧬🧫
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted Transcriptional Repression by Induced Proximity
Most cancer driving proteins remain undruggable due to the absence of ligandable pockets and their reliance on intrinsically disordered or protein-DNA/protein-protein interactions. Transcription facto...
www.biorxiv.org
October 22, 2025 at 8:15 PM
🎉 Excited to share the first bioRxiv & medRxiv preprint from my PostDoc.
It’s been — and continues to be — an incredible journey into the world of epigenetics, exploring how we can reprogram oncogenic transcription factor activity using chemical inducers of proximity.
👨🔬🧪🧬🧫
It’s been — and continues to be — an incredible journey into the world of epigenetics, exploring how we can reprogram oncogenic transcription factor activity using chemical inducers of proximity.
👨🔬🧪🧬🧫
Reposted by CEStieger.bsky.social
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted Transcriptional Repression by Induced Proximity
Most cancer driving proteins remain undruggable due to the absence of ligandable pockets and their reliance on intrinsically disordered or protein-DNA/protein-protein interactions. Transcription facto...
www.biorxiv.org
October 22, 2025 at 7:11 PM
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by CEStieger.bsky.social
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
October 5, 2025 at 9:35 AM
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Reposted by CEStieger.bsky.social
Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation - Nature Chemistry
Our understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h...
www.nature.com
August 20, 2025 at 9:58 PM
Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Was really fun working with you on that project! 😃
Happy to share the publication of my postdoc research in the Hackenberger lab in @jacs.acspublications.org. Privileged to have worked alongside colleagues at @fmp-berlin.de and Tubulis GmbH. A big thank you to @humboldt-foundation.de for funding this exciting project!!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols
We introduce aryl thiols as nucleophiles for site-specific protein and antibody bioconjugation, which allows the orthogonal labeling of native cysteines for double modification strategies. In a high-y...
pubs.acs.org
May 8, 2025 at 9:56 PM
Was really fun working with you on that project! 😃
Reposted by CEStieger.bsky.social
Interesting talk by Mark de Geus at #Lunteren. He talked about his work on incorporating aryl thiols into proteins and exploring, if they can be labeled selectively over cysteine residues. Cool applications to site-selective protein labeling.
March 25, 2025 at 1:33 PM
Interesting talk by Mark de Geus at #Lunteren. He talked about his work on incorporating aryl thiols into proteins and exploring, if they can be labeled selectively over cysteine residues. Cool applications to site-selective protein labeling.
Reposted by CEStieger.bsky.social
My write-up on this, if it’s of any use or interest: nanoscale.blogspot.com/2025/02/indi...
Indirect costs + potential unintended consequences
It's been another exciting week where I feel compelled to write about the practice of university-based research in the US. I've written ab...
nanoscale.blogspot.com
February 9, 2025 at 12:27 AM
My write-up on this, if it’s of any use or interest: nanoscale.blogspot.com/2025/02/indi...
Reposted by CEStieger.bsky.social
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
The Senate HELP Committee has jurisdiction over NIH.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
February 8, 2025 at 3:27 AM
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
Reposted by CEStieger.bsky.social
‼️PhD Position in Chemical Biology at the University Antwerp‼️#chembio
✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...
✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...
Doctoral scholarship holder chemical biology | University of Antwerp
YUFE vacancies
www.uantwerpen.be
January 25, 2025 at 1:19 PM
‼️PhD Position in Chemical Biology at the University Antwerp‼️#chembio
✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...
✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...
Reposted by CEStieger.bsky.social
Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
April 26, 2024 at 8:00 AM
Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper