Chuling Ding
@c-ding.bsky.social
Posdoc @Wellcome Sanger Institute
Somatic mutations in lung diseases
Somatic mutations in lung diseases
Reposted by Chuling Ding
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Chuling Ding
The ‘cell of origin’ of the second most common lung cancer and the way that it spreads to become dominant have been discovered 🔬
A deeper understanding of lung cancer development could lead to earlier detection and possible prevention in the future
www.sanger.ac.uk/news_item/or...
A deeper understanding of lung cancer development could lead to earlier detection and possible prevention in the future
www.sanger.ac.uk/news_item/or...
Origins of common lung cancer that affects smokers discovered
Research uncovers insights into how particular cancer cells develop and spread throughout the lung
www.sanger.ac.uk
May 2, 2025 at 3:12 PM
The ‘cell of origin’ of the second most common lung cancer and the way that it spreads to become dominant have been discovered 🔬
A deeper understanding of lung cancer development could lead to earlier detection and possible prevention in the future
www.sanger.ac.uk/news_item/or...
A deeper understanding of lung cancer development could lead to earlier detection and possible prevention in the future
www.sanger.ac.uk/news_item/or...
Reposted by Chuling Ding
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The somatic mutation landscape of normal gastric epithelium - Nature
Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influen...
www.nature.com
March 20, 2025 at 2:59 PM
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...