Ben Sabari
@bsabari.bsky.social
Assistant Professor at UTSW studying nuclear organization by nuclear condensates
Congrats, Josh! Exciting work!
November 4, 2025 at 6:13 PM
Congrats, Josh! Exciting work!
Big thank you to Hue Sun Chan, @jonaswessen.bsky.social, Nancy De La Cruz, and @heankel.bsky.social for making this wonderful interdisciplinary collaboration a success.
October 22, 2025 at 6:30 PM
Big thank you to Hue Sun Chan, @jonaswessen.bsky.social, Nancy De La Cruz, and @heankel.bsky.social for making this wonderful interdisciplinary collaboration a success.
This is all part of a bigger story related to the IDR "specificity code" and the IDR sequence-function relationship, and provides compelling evidence that specificity can be encoded within the chemical patterns of amino acids and the multivalent networks they enable.
October 22, 2025 at 6:30 PM
This is all part of a bigger story related to the IDR "specificity code" and the IDR sequence-function relationship, and provides compelling evidence that specificity can be encoded within the chemical patterns of amino acids and the multivalent networks they enable.
This work builds off of my lab's 2023 paper that demonstrated selective and functional partitioning of positive regulators of transcription by patterened charge blocks
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Functional partitioning of transcriptional regulators by patterned charge blocks
Charge patterning in disordered regions of transcriptional regulators mediates selective
partitioning into MED1IDR condensates for gene activation.
www.cell.com
October 22, 2025 at 6:30 PM
This work builds off of my lab's 2023 paper that demonstrated selective and functional partitioning of positive regulators of transcription by patterened charge blocks
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
As the model only accounts for multivalent interactions among polymers, the accuracy of its predictions demonstrates that specificity can arise directly from multivalent contacts among disordered regions without needing to invoke ordered-structure-mediated interactions
October 22, 2025 at 6:30 PM
As the model only accounts for multivalent interactions among polymers, the accuracy of its predictions demonstrates that specificity can arise directly from multivalent contacts among disordered regions without needing to invoke ordered-structure-mediated interactions
Congratulations! Well deserved!
October 3, 2025 at 5:35 PM
Congratulations! Well deserved!