Congratulations Dr. @heankel.bsky.social !

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

Happy holidays from the lab! Congrats to this group on all they have accomplished in 2024

Organization of complexes by condensates regulate transcription in development, signaling, and environment sensing (Figures 4 and 5). Furthermore, this organization is dysregulated in human disease (Figure 6), providing evidence for its importat regulatory role in physiology.

For transcription, classic models have focused on how complexes assemble to direct and regulate RNA Pol II's activity. Condensates provide additional regulatory mechanisms for promoting or preventing these processes in the crowded nuclear environment (see Figure 3).

Macromolecules assemble into complexes typically through stoichiometric interactions. Complexes assemble into condensates through dynamic multivalent interactions. This larger length scale organization can promote or prevent complex assembly, function, and activity (Figure 2).