Brice Letcher
@bricoletc.bsky.social
Researcher in genomics, evolution, biology 🧬
Currently Postdoc on DNA Elimination in nematodes @LBMC/@CNRS | Prev. PhD on malaria genomics @EMBL-EBI/@Cambridge
Currently Postdoc on DNA Elimination in nematodes @LBMC/@CNRS | Prev. PhD on malaria genomics @EMBL-EBI/@Cambridge
Beautiful cytology of zebra and Bengalese finch embryos showing their germline-restricted chromosomes are eliminated from somatic cells by the time of oviposition (egg-laying)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mechanisms and timing of programmed DNA elimination in songbirds
It is commonly assumed that multicellular organisms contain the same genetic information in all the cells of an individual. However, there is a growing list of species in which parts of the genome are...
www.biorxiv.org
September 24, 2025 at 7:49 AM
Beautiful cytology of zebra and Bengalese finch embryos showing their germline-restricted chromosomes are eliminated from somatic cells by the time of oviposition (egg-laying)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Brice Letcher
Peut-on détruire les PFAS ? 🧐
La dégradation de ces « polluants éternels » reste un enjeu majeur pour l’environnement et la santé et c’est tout l’objectif des recherches menées par Marie-Pierre Krafft, physico-chimiste au CNRS.
La dégradation de ces « polluants éternels » reste un enjeu majeur pour l’environnement et la santé et c’est tout l’objectif des recherches menées par Marie-Pierre Krafft, physico-chimiste au CNRS.
Brève de science : Détruire les PFAS
Les PFAS sont ce que l’on appelle des « polluants éternels », des composés aux propriétés extraordinaires (ils résistent aux fortes chaleurs,
www.cnrs.fr
August 27, 2025 at 9:13 AM
Peut-on détruire les PFAS ? 🧐
La dégradation de ces « polluants éternels » reste un enjeu majeur pour l’environnement et la santé et c’est tout l’objectif des recherches menées par Marie-Pierre Krafft, physico-chimiste au CNRS.
La dégradation de ces « polluants éternels » reste un enjeu majeur pour l’environnement et la santé et c’est tout l’objectif des recherches menées par Marie-Pierre Krafft, physico-chimiste au CNRS.
Reposted by Brice Letcher
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN
May 27, 2025 at 6:21 PM
#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN
Reposted by Brice Letcher
The days of Google Docs are ending; we enter the age of Docs, made by France's Interministerial Directorate for Digital Affairs and Germany's Center for Digital Sovereignty of Public Administration.
We need more governments to collaborate on public software projects to achieve digital sovereignty.
We need more governments to collaborate on public software projects to achieve digital sovereignty.
France and Germany unveil Docs, a homegrown alternative to Google Docs
The Trump administration has set out to drastically reshape the relationship between the US and Europe. In response, Brussels is scrambling to adapt to this new reality,...
www.techspot.com
April 21, 2025 at 2:25 PM
The days of Google Docs are ending; we enter the age of Docs, made by France's Interministerial Directorate for Digital Affairs and Germany's Center for Digital Sovereignty of Public Administration.
We need more governments to collaborate on public software projects to achieve digital sovereignty.
We need more governments to collaborate on public software projects to achieve digital sovereignty.
Reposted by Brice Letcher
Preprint on hifiasm Nanopore-only assembly. Led by Haoyu Cheng: www.biorxiv.org/content/10.1...
Efficient near telomere-to-telomere assembly of Nanopore Simplex reads
Telomere-to-telomere (T2T) assembly is the ultimate goal for de novo genome assembly. Existing algorithms capable of near T2T assembly all require Oxford Nanopore Technologies (ONT) ultra-long reads w...
www.biorxiv.org
April 18, 2025 at 9:54 PM
Preprint on hifiasm Nanopore-only assembly. Led by Haoyu Cheng: www.biorxiv.org/content/10.1...
Reposted by Brice Letcher
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Brice Letcher
🏆 Research integrity consultant and image forensics expert @elisabethbik.bsky.social has uncovered fraudulent data in over 7,600 scientific papers and exposed the practices of ‘paper mills’ that produce counterfeit scientific articles. She is honoured with the €200K Individual Award. Congrats!
March 14, 2025 at 10:14 PM
🏆 Research integrity consultant and image forensics expert @elisabethbik.bsky.social has uncovered fraudulent data in over 7,600 scientific papers and exposed the practices of ‘paper mills’ that produce counterfeit scientific articles. She is honoured with the €200K Individual Award. Congrats!
Reposted by Brice Letcher
@science.org G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation | Science www.science.org/doi/10.1126/... @sahilbatra.bsky.social @benallwein.bsky.social @dirkremus.bsky.social www.mskcc.org/research/ski...
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 7, 2025 at 4:24 PM
@science.org G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation | Science www.science.org/doi/10.1126/... @sahilbatra.bsky.social @benallwein.bsky.social @dirkremus.bsky.social www.mskcc.org/research/ski...
Reposted by Brice Letcher
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
March 7, 2025 at 7:18 AM
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
Reposted by Brice Letcher
Reposted by Brice Letcher
MAYosis is coming... register and submit abstracts here.
meiosis.cornell.edu/mayosis2025/...
meiosis.cornell.edu/mayosis2025/...
MAYosis 2025
meiosis.cornell.edu
January 22, 2025 at 4:21 PM
MAYosis is coming... register and submit abstracts here.
meiosis.cornell.edu/mayosis2025/...
meiosis.cornell.edu/mayosis2025/...
Reposted by Brice Letcher
💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>
The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis
Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.
cell.com
January 9, 2025 at 5:24 PM
💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>
Reposted by Brice Letcher
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
December 10, 2024 at 2:11 AM
Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...
Reposted by Brice Letcher
The Institute for Integrative Biology of the Cell #I2BCParisSaclay is seeking to recruit new group leaders in cell biology #UnivParisSaclay #CNRSbiologie #CEAParisSaclay
The application dealine is February 28, 2025
The application dealine is February 28, 2025
November 22, 2024 at 5:33 AM
The Institute for Integrative Biology of the Cell #I2BCParisSaclay is seeking to recruit new group leaders in cell biology #UnivParisSaclay #CNRSbiologie #CEAParisSaclay
The application dealine is February 28, 2025
The application dealine is February 28, 2025