A very good read for machine learning if you using RUST 🦀 and Polars. so a very good book. ericfecteau.ca/data/rust-da.... You can use the Linfa or the smartcore for the implementation of the machine learning algorithm.

how do we feel about putting JSON in the INFO field of a VCF?

This is very cool work and I'm happy to see it published. Vcfexpress by @brent-p.bsky.social and @aaronquinlan.bsky.social allows building (essentially) arbitrary VCF filters expressed in lua code with parsing & eval powered by rust!

academic.oup.com/bioinformati...

vcfexpress applies simple user expressions variants in a VCF.
it can replace one-off python scripts to manipulate VCFs, likely with better performance.

we'd like to collect use-cases here: github.com/brentp/vcfex...

if you have a use-case and want some pointers, open an issue

vcfexpress is a command-line tool built in rust that lets users apply lua expressions to modify or filter a vcf from the command-line
github.com/brentp/vcfex...
new release with better docs github.com/brentp/vcfex...
and examples github.com/brentp/vcfex...

I am looking for a mentor for the rust programming language. My latest issue is with trait bounds (github.com/brentp/simpl...) but I have a few things I generally hit. I can compensate with $$ or interesting problems. :)

Please share with relevant people and feel free to DM.

with Jason K from @aaronquinlan.bsky.social lab, I have been dusting off fraguracy, which evaluates sequencing error rates using the portion of bases from paired end reads that overlap. New release adds, among other niceties, tracking for distance to homopolymers
github.com/brentp/fragu...