Bose Lab Sheffield
@bose-lab.bsky.social
Working on mechanistic enhancer biology at the University of Sheffield, UK.
Part of Sheffield Nucleic Acids Institute and Centre for Single Molecule Biology
See also @danbose.bsky.social
Part of Sheffield Nucleic Acids Institute and Centre for Single Molecule Biology
See also @danbose.bsky.social
Exciting new packages!! Very cool ❄️ to see the new microscope (JEMma) added to the cryoEM facility to keep @AvaArctica company @sheffielduni.bsky.social @mcb-sheffield.bsky.social! (Ok, it does look a little bit like a washing machine!) lookout for more details soon!
January 29, 2025 at 3:22 PM
Exciting new packages!! Very cool ❄️ to see the new microscope (JEMma) added to the cryoEM facility to keep @AvaArctica company @sheffielduni.bsky.social @mcb-sheffield.bsky.social! (Ok, it does look a little bit like a washing machine!) lookout for more details soon!
Reposted by Bose Lab Sheffield
Amazing #RNA structural ensembles! Really highlights how important #singlemolecule approaches are for finding mechanism in sustems and models that move! www.nature.com/articles/s41...
The conformational space of RNase P RNA in solution - Nature
Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.
www.nature.com
December 20, 2024 at 6:28 AM
Amazing #RNA structural ensembles! Really highlights how important #singlemolecule approaches are for finding mechanism in sustems and models that move! www.nature.com/articles/s41...
Reposted by Bose Lab Sheffield
Posting this awesome work from the summer led by Katie in our team- currently undergoing some exciting new upgrades :) www.biorxiv.org/content/10.1...
Cooperation between Intrinsically Disordered Regions regulates CBP condensate behaviour
Creb binding protein (CBP) and EP300 (p300) are transcription coactivators that bind at cis -regulatory elements and regulate gene expression in multicellular organisms. They contain large intrinsical...
www.biorxiv.org
November 8, 2024 at 7:48 AM
Posting this awesome work from the summer led by Katie in our team- currently undergoing some exciting new upgrades :) www.biorxiv.org/content/10.1...
Reposted by Bose Lab Sheffield
With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here:
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
November 1, 2024 at 8:40 AM
With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here:
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
Reposted by Bose Lab Sheffield
Fantastic, well articulated review reconciling how regulatory complexes at the molecular level function in the context of transcriptional condensates.
Regulation of transcription by condensates, great review by @bsabari.bsky.social and coll.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcription regulation by biomolecular condensates - Nature Reviews Molecular Cell Biology
Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by compartmentalizing its machinery in the crowded nu...
www.nature.com
November 13, 2024 at 8:46 PM
Fantastic, well articulated review reconciling how regulatory complexes at the molecular level function in the context of transcriptional condensates.
Reposted by Bose Lab Sheffield
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
Reposted by Bose Lab Sheffield
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
t.co
November 15, 2024 at 9:13 PM
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
Reposted by Bose Lab Sheffield
Bringing the lab account over too!! Check us out at @bose-lab.bsky.social 🧬🥼🧪⚗️🔬🪴
November 15, 2024 at 8:16 PM
Bringing the lab account over too!! Check us out at @bose-lab.bsky.social 🧬🥼🧪⚗️🔬🪴