Bonnie Lee
@bonniee-leee.bsky.social
PhD in Neuroscience | Postdoctoral Fellow at @camhnews.bsky.social & @whrcluster.bsky.social
@istaart.bsky.social Ambassador Alumni
🧠 women’s health, sex differences, Alzheimer’s disease, brain & cognitive aging
https://www.galealab.com/bonnielee
@istaart.bsky.social Ambassador Alumni
🧠 women’s health, sex differences, Alzheimer’s disease, brain & cognitive aging
https://www.galealab.com/bonnielee
Pinned
Bonnie Lee
@bonniee-leee.bsky.social
· Mar 14
Tuesday we got to see @bonniee-leee.bsky.social transform into Dr.Bonnie Lee!! Many thanks to her committee, external examiner Kristen Zuloaga & university examiners Jessica Rosin and Wendy Robinson!!the second last UBC graduate student from the Galea lab to finish!! Thanks to UBC for the memories
Beyond grateful to everyone who has been part of this incredible journey 🩷✨
Reposted by Bonnie Lee
Do we really need to do research specifically on women's health?
The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men.
Yes.
The answer is yes.
academic.oup.com/eurheartj/ar...
The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men.
Yes.
The answer is yes.
academic.oup.com/eurheartj/ar...
Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial
AbstractBackground and Aims. Recent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients witho
academic.oup.com
August 30, 2025 at 3:25 PM
Do we really need to do research specifically on women's health?
The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men.
Yes.
The answer is yes.
academic.oup.com/eurheartj/ar...
The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men.
Yes.
The answer is yes.
academic.oup.com/eurheartj/ar...
Reposted by Bonnie Lee
✨ New Publication Feature ✨ How you take #menopausal #hormonetherapy may shape its impact on #cognition.
A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter.
Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU
A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter.
Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU
August 28, 2025 at 5:36 PM
✨ New Publication Feature ✨ How you take #menopausal #hormonetherapy may shape its impact on #cognition.
A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter.
Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU
A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter.
Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU
Reposted by Bonnie Lee
We’ve been working hard in the lab to understand the translational links to our preclinical work. Here’s our latest in preprint (& long time in process so many people to thank) but for now kudos to @bonniee-leee.bsky.social www.researchsquare.com/article/rs-7...
Previous parity differentially influences cognition in later life depending on dementia status
Sex influences cognitive aging and dementia, yet research on the impact of female-specific factors, such as parity and fetal sex, on later-life cognition remains limited and equivocal. Inconsistencies...
www.researchsquare.com
August 15, 2025 at 8:10 PM
We’ve been working hard in the lab to understand the translational links to our preclinical work. Here’s our latest in preprint (& long time in process so many people to thank) but for now kudos to @bonniee-leee.bsky.social www.researchsquare.com/article/rs-7...
Reposted by Bonnie Lee
US POINTER study showed a significant improvement in global cognition for a structured intervention (physical, social, and cognitive activities, MIND diet, health monitoring) compared to self-guided intervention equivalent to 1-2 years of aging #AAIC2025. Evidence that behavior change can work
July 28, 2025 at 6:55 PM
US POINTER study showed a significant improvement in global cognition for a structured intervention (physical, social, and cognitive activities, MIND diet, health monitoring) compared to self-guided intervention equivalent to 1-2 years of aging #AAIC2025. Evidence that behavior change can work
Really honoured to receive the @istaart.bsky.social Sex and Gender PIA Publication of the Year Award 🌟 Thank you to the PIA & @bucklr01.bsky.social!
And ofc a big thank you to my co-authors, collaborators, & importantly, my supervisor @liisagalea.bsky.social 🙌 #endALZ @alzassociation.bsky.social
And ofc a big thank you to my co-authors, collaborators, & importantly, my supervisor @liisagalea.bsky.social 🙌 #endALZ @alzassociation.bsky.social
July 26, 2025 at 7:39 PM
Really honoured to receive the @istaart.bsky.social Sex and Gender PIA Publication of the Year Award 🌟 Thank you to the PIA & @bucklr01.bsky.social!
And ofc a big thank you to my co-authors, collaborators, & importantly, my supervisor @liisagalea.bsky.social 🙌 #endALZ @alzassociation.bsky.social
And ofc a big thank you to my co-authors, collaborators, & importantly, my supervisor @liisagalea.bsky.social 🙌 #endALZ @alzassociation.bsky.social
Looking forward to #AAIC2025!! Hope to see many of you there 🤩
At #AAIC2025 in Toronto this coming week? Check out these talks and posters from the lab! Come say hi and let us know your thoughts! @bonniee-leee.bsky.social
July 25, 2025 at 8:40 PM
Looking forward to #AAIC2025!! Hope to see many of you there 🤩
Had a great time presenting my latest work on effects of pregnancy and AD risk on functional connectivity in middle age at #OSSD2025 🧠⚡️
Thank you @ossdcomm.bsky.social @whrcluster.bsky.social @camhnews.bsky.social #womenmind for hosting this fantastic Pre-Meeting and the opportunity to speak!!
Thank you @ossdcomm.bsky.social @whrcluster.bsky.social @camhnews.bsky.social #womenmind for hosting this fantastic Pre-Meeting and the opportunity to speak!!
June 1, 2025 at 6:42 PM
Had a great time presenting my latest work on effects of pregnancy and AD risk on functional connectivity in middle age at #OSSD2025 🧠⚡️
Thank you @ossdcomm.bsky.social @whrcluster.bsky.social @camhnews.bsky.social #womenmind for hosting this fantastic Pre-Meeting and the opportunity to speak!!
Thank you @ossdcomm.bsky.social @whrcluster.bsky.social @camhnews.bsky.social #womenmind for hosting this fantastic Pre-Meeting and the opportunity to speak!!
Reposted by Bonnie Lee
Greetings from Albuquerque, New Mexico! We are ready for the @ossdcomm.bsky.social meeting!
w/ @liisagalea.bsky.social @travisehodges.bsky.social @bonniee-leee.bsky.social
w/ @liisagalea.bsky.social @travisehodges.bsky.social @bonniee-leee.bsky.social
June 1, 2025 at 3:36 AM
Greetings from Albuquerque, New Mexico! We are ready for the @ossdcomm.bsky.social meeting!
w/ @liisagalea.bsky.social @travisehodges.bsky.social @bonniee-leee.bsky.social
w/ @liisagalea.bsky.social @travisehodges.bsky.social @bonniee-leee.bsky.social
The end of a chapter.. 🥹💙 Endless thank yous to everyone who has been a part of this journey - lab mates and friends, other graduate students, mentors, collaborators, and of course, my supervisor, @liisagalea.bsky.social, for the support and mentorship over the years. #PhDone !!!!!! 👩🏻🎓
May 22, 2025 at 4:52 AM
The end of a chapter.. 🥹💙 Endless thank yous to everyone who has been a part of this journey - lab mates and friends, other graduate students, mentors, collaborators, and of course, my supervisor, @liisagalea.bsky.social, for the support and mentorship over the years. #PhDone !!!!!! 👩🏻🎓
Reposted by Bonnie Lee
Women and gender-diverse communities are facing renewed challenges as recent policy changes threaten access to healthcare and research support. Our latest blog explores how past advocacy efforts can guide us through today’s setbacks.
📖 Full blog: ow.ly/8RfJ50VylCo
📖 Full blog: ow.ly/8RfJ50VylCo
April 11, 2025 at 8:10 PM
Women and gender-diverse communities are facing renewed challenges as recent policy changes threaten access to healthcare and research support. Our latest blog explores how past advocacy efforts can guide us through today’s setbacks.
📖 Full blog: ow.ly/8RfJ50VylCo
📖 Full blog: ow.ly/8RfJ50VylCo
Reposted by Bonnie Lee
I’m behind on sharing preprints because of …the rise of fascism but we need to celebrate wins. Here is @bonniee-leee.bsky.social ‘s last (but not least) paper of her PhD! On functional connectivity differences in middle-aged females based on parity and genotype! www.biorxiv.org/content/10.1...
Parity and APOEε4 genotype contribute distinct changes to functional connectivity across the middle-aged brain
Cognition and its underlying neurobiology change throughout the trajectory of aging, with prominent sex differences and influences of sex-specific factors. Research has shown that parity (pregnancy an...
www.biorxiv.org
April 9, 2025 at 1:44 PM
I’m behind on sharing preprints because of …the rise of fascism but we need to celebrate wins. Here is @bonniee-leee.bsky.social ‘s last (but not least) paper of her PhD! On functional connectivity differences in middle-aged females based on parity and genotype! www.biorxiv.org/content/10.1...
Reposted by Bonnie Lee
Join us for a Multidisciplinary Look at Menopause!
🗓️ April 28 – 1:00 PM EST
Hear insights from the next generation of menopause researchers!
🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap
#MenopauseResearch
🗓️ April 28 – 1:00 PM EST
Hear insights from the next generation of menopause researchers!
🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap
#MenopauseResearch
April 1, 2025 at 5:36 PM
Join us for a Multidisciplinary Look at Menopause!
🗓️ April 28 – 1:00 PM EST
Hear insights from the next generation of menopause researchers!
🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap
#MenopauseResearch
🗓️ April 28 – 1:00 PM EST
Hear insights from the next generation of menopause researchers!
🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap
#MenopauseResearch
Reposted by Bonnie Lee
Did you know that APOEe4, a genetic risk factor late-onset sporadic #AlzheimersDisease (AD) affects brain aging differently in males and females? 🧠 👀
📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....
📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....
March 28, 2025 at 2:15 PM
Did you know that APOEe4, a genetic risk factor late-onset sporadic #AlzheimersDisease (AD) affects brain aging differently in males and females? 🧠 👀
📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....
📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....
Beyond grateful to everyone who has been part of this incredible journey 🩷✨
Tuesday we got to see @bonniee-leee.bsky.social transform into Dr.Bonnie Lee!! Many thanks to her committee, external examiner Kristen Zuloaga & university examiners Jessica Rosin and Wendy Robinson!!the second last UBC graduate student from the Galea lab to finish!! Thanks to UBC for the memories
March 14, 2025 at 6:13 AM
Beyond grateful to everyone who has been part of this incredible journey 🩷✨
Reposted by Bonnie Lee
Women's research remains underrepresented in scientific studies. That's why CAMH womenmind™ is committed to closing the gender gap in research with 30+ grants & awards distributed to advance women in science and research 💜.
MORE:
www.camh.ca/en/get-invol...
#IDWGIS2025
MORE:
www.camh.ca/en/get-invol...
#IDWGIS2025
February 11, 2025 at 3:17 PM
Women's research remains underrepresented in scientific studies. That's why CAMH womenmind™ is committed to closing the gender gap in research with 30+ grants & awards distributed to advance women in science and research 💜.
MORE:
www.camh.ca/en/get-invol...
#IDWGIS2025
MORE:
www.camh.ca/en/get-invol...
#IDWGIS2025
New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1...
Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏
Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats - Biology of Sex Differences
Background Alzheimer’s disease (AD) disproportionately and uniquely affects females, and these sex differences are further exacerbated by the presence of Apolipoprotein (APOE) ε4 alleles, the top gene...
link.springer.com
February 11, 2025 at 8:06 PM
New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1...
Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏
Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏
Reposted by Bonnie Lee
Check out the full statement by Dr. Liisa Galea on our website: womenshealthresearchcluster.com/learn/womens...
February 6, 2025 at 2:13 PM
Check out the full statement by Dr. Liisa Galea on our website: womenshealthresearchcluster.com/learn/womens...
Reposted by Bonnie Lee
Applications are now open for the ISTAART Ambassador Program 2025-26!
This program offers early-career researchers access to #AAIC25, as well as year-round training, networking, and mentoring opportunities.
Apply by Feb 10, 2025, at alz.org/ISTAARTambassadors!
This program offers early-career researchers access to #AAIC25, as well as year-round training, networking, and mentoring opportunities.
Apply by Feb 10, 2025, at alz.org/ISTAARTambassadors!
January 9, 2025 at 1:56 PM
Applications are now open for the ISTAART Ambassador Program 2025-26!
This program offers early-career researchers access to #AAIC25, as well as year-round training, networking, and mentoring opportunities.
Apply by Feb 10, 2025, at alz.org/ISTAARTambassadors!
This program offers early-career researchers access to #AAIC25, as well as year-round training, networking, and mentoring opportunities.
Apply by Feb 10, 2025, at alz.org/ISTAARTambassadors!
Reposted by Bonnie Lee
A mouse hippocampus labeled for oligodendrocytes 🟡, myelin 🔵, and nuclei ⚪️. You can appreciate how the distribution of myelin and oligodendrocytes is not homogeneous in the overall hippocampal formation.
#FluorescenceFriday
#FluorescenceFriday
December 20, 2024 at 10:36 AM
A mouse hippocampus labeled for oligodendrocytes 🟡, myelin 🔵, and nuclei ⚪️. You can appreciate how the distribution of myelin and oligodendrocytes is not homogeneous in the overall hippocampal formation.
#FluorescenceFriday
#FluorescenceFriday
Reposted by Bonnie Lee
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications
The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...
www.nature.com
December 6, 2024 at 6:44 AM
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
Super proud of this one 🤩 Thank you to all my co-authors!
Read it here now: www.nature.com/articles/s41...
Read it here now: www.nature.com/articles/s41...
November 26, 2024 at 3:58 AM
Super proud of this one 🤩 Thank you to all my co-authors!
Read it here now: www.nature.com/articles/s41...
Read it here now: www.nature.com/articles/s41...