Bob Coelingh
@bobcoelingh.bsky.social
PhD student at Utrecht University
Interested in virology and cryo-EM
Interested in virology and cryo-EM
Reposted by Bob Coelingh
Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
November 14, 2025 at 3:45 PM
Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
Reposted by Bob Coelingh
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 4:47 PM
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Reposted by Bob Coelingh
"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells
Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...
www.biorxiv.org
July 25, 2025 at 12:09 PM
"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bob Coelingh
Interested in our recent norovirus NS3 work? 👇
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
July 15, 2025 at 3:42 PM
Interested in our recent norovirus NS3 work? 👇
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Reposted by Bob Coelingh
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Bob Coelingh
Think coronavirus spikes have run out of surprises? Think again.
Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.
www.biorxiv.org/content/10.1...
This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.
www.biorxiv.org/content/10.1...
This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
May 23, 2025 at 5:02 AM
Think coronavirus spikes have run out of surprises? Think again.
Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.
www.biorxiv.org/content/10.1...
This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.
www.biorxiv.org/content/10.1...
This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
Reposted by Bob Coelingh
I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊
"A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! 🎉
"A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! 🎉
March 26, 2025 at 4:31 PM
I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊
"A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! 🎉
"A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! 🎉
Reposted by Bob Coelingh
More picornavirus research from us! 😄
Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection https://www.biorxiv.org/content/10.1101/2025.03.11.642588v1
March 16, 2025 at 3:50 PM
More picornavirus research from us! 😄
Reposted by Bob Coelingh
Latest #virology research from the lab! 👇
Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
www.biorxiv.org/content/10.1...
Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
www.biorxiv.org/content/10.1...
The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses
Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...
www.biorxiv.org
February 23, 2025 at 12:56 PM
Latest #virology research from the lab! 👇
Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
www.biorxiv.org/content/10.1...
Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
www.biorxiv.org/content/10.1...
Reposted by Bob Coelingh
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
tiny.cc
December 27, 2024 at 7:59 AM
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Reposted by Bob Coelingh
Reposted by Bob Coelingh
Streamlining segmentation of cryo-electron tomography datasets with Ais pubmed.ncbi.nlm.nih.gov/39704648/
December 21, 2024 at 11:30 PM
Streamlining segmentation of cryo-electron tomography datasets with Ais pubmed.ncbi.nlm.nih.gov/39704648/
Reposted by Bob Coelingh
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists
Origins and spread of the vaccine-derived viruses remain mysterious
www.science.org
December 12, 2024 at 5:13 PM
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
Amazing science at the Science for Life meeting in Utrecht. The talk by Julia Mahamid was incredible; it most definitely helped me to secure a poster prize too!
Had a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆
December 2, 2024 at 7:14 PM
Amazing science at the Science for Life meeting in Utrecht. The talk by Julia Mahamid was incredible; it most definitely helped me to secure a poster prize too!
Reposted by Bob Coelingh
Excited to share our first preprint of 2024! 🎉
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
January 12, 2024 at 2:41 PM
Excited to share our first preprint of 2024! 🎉
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
researchsquare.com/article/rs-3...
This study focuses on PDCoV, an emerging enteric pathogen.
We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.
#virology #cryoEM
Reposted by Bob Coelingh
Our #TeamTomo adventure continues! 🔬
Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍
@bobcoelingh.bsky.social
Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍
@bobcoelingh.bsky.social
November 9, 2023 at 12:32 PM
Our #TeamTomo adventure continues! 🔬
Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍
@bobcoelingh.bsky.social
Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍
@bobcoelingh.bsky.social