Raphaël Chaleil
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blastwizard.bsky.social
Raphaël Chaleil
@blastwizard.bsky.social
Computational Protein Engineer at @basecamp-research.bsky.social
Reposted by Raphaël Chaleil
How can AI and nature’s hidden code lead to programmable gene therapies?

Basecamp Research Co-founder & CEO GlenGowers.bsky.social explores this question at @financialtimes.com Times Live Global Pharma and Biotech Summit (Nov 11–12) with industry leaders.

👉 For full details, visit bit.ly/4pPcJpd
November 6, 2025 at 10:11 AM
Reposted by Raphaël Chaleil
A real shame that the future of CASP is in doubt. There is still a lot of progress to be assessed (complexes, nucleic acids, ligands, ensembles). CASP has also been a pioneer in how to run blind assessments.

www.science.org/content/arti...
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
www.science.org
July 4, 2025 at 4:11 PM
Reposted by Raphaël Chaleil
Seen on LinkedIn, a bit on the nose, comparing Machine learning to AI and now GenAI and AgenticAI
May 31, 2025 at 4:29 AM
First roses of the year.
April 25, 2025 at 4:46 PM
Reposted by Raphaël Chaleil
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...

Please share!
'
my.corehr.com
February 22, 2025 at 8:07 PM
Reposted by Raphaël Chaleil
youtu.be/q32Zz2dBkos

If you want to know how Europeans feel listen to Claude Malhuret, He is the leader of the independents in France. This is how they see the US now.

That's the full translation.
Worth a listen
Video IGGY HOBO translation v1
YouTube video by yep it's,me
youtu.be
March 5, 2025 at 8:35 PM
Reposted by Raphaël Chaleil
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Reposted by Raphaël Chaleil
Pass it on.
#StandWithUkraine
February 28, 2025 at 8:44 PM
Reposted by Raphaël Chaleil
Favourite paper of 2017

"Protein structure determination using metagenome sequence data" by Ovchinnikov et al. (1/4)

www.science.org/doi/10.1126/...
January 8, 2025 at 12:05 PM
Reposted by Raphaël Chaleil

Good article on the OpenFold work of @moalquraishi.bsky.social, who poses the interesting question: If we can predict how proteins fold without understanding how they do it, “are we even legitimately doing science anymore, or is it something different?“ magazine.hms.harvard.edu/articles/did...
Did AI Solve the Protein-Folding Problem?
Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions
magazine.hms.harvard.edu
December 30, 2024 at 10:07 PM
Reposted by Raphaël Chaleil
Basecamp Research cofounder and CEO Glen Gowers, Ph.D., spoke about AI and drug discovery at the 2024 Forbes Healthcare Summit in New York City. #ForbesHealth
trib.al/aVWj2tF

Thanks to @forbes.com and @thealexknapp.bsky.social for an amazing summit a thought-provoking event.
December 6, 2024 at 1:55 PM
Reposted by Raphaël Chaleil
Conclusions from RNA section at #CASP16, without a template all fail. All small targets had a template.
December 3, 2024 at 4:10 PM
Reposted by Raphaël Chaleil
Carl Sagan nailed it back in 1995.
November 18, 2024 at 5:46 PM
First snow, that's a bit unusual at this time of the year.
November 19, 2024 at 7:54 AM
November and the rose in front of the house is still flowering.
November 17, 2024 at 2:52 PM
Reposted by Raphaël Chaleil
New from me: Basecamp Research, which is collecting reference-quality genomes in collaboration with research groups around the world, says its protein folding model significantly out-performs Deepmind's Alphafold2.

www.forbes.com/sites/alexkn...
This Startup Says It Can Beat Deepmind’s Gamechanging Protein AI
Basecamp Research says its software platform can better predict the way proteins behave — not with better algorithms, but with higher-quality data.
www.forbes.com
March 12, 2024 at 1:43 PM
Reposted by Raphaël Chaleil