Quantitative Biology in Aging and Disease
@biologyaging.bsky.social
Chandra lab twitter. Opinions are personal and do not reflect Mayo Clinic. https://www.mayo.edu/research/faculty/chandra-tamir-ph-d/bio-20571594
Reposted by Quantitative Biology in Aging and Disease
For 50 years, Voyageurs National Park has brought millions of people from around the world to see all that the Land of 10,000 Lakes has to offer - remote island camping, paddling, world-class fishing, and abundant winter activities.
Happy birthday, Voyageurs!
Happy birthday, Voyageurs!
April 8, 2025 at 5:32 PM
For 50 years, Voyageurs National Park has brought millions of people from around the world to see all that the Land of 10,000 Lakes has to offer - remote island camping, paddling, world-class fishing, and abundant winter activities.
Happy birthday, Voyageurs!
Happy birthday, Voyageurs!
Reposted by Quantitative Biology in Aging and Disease
Yesterday, I fondly remembered my dear friend Leonard Nimoy, who would have turned 94. His legacy lives on in our hearts. Just days ago, Bill Shatner celebrated his 94th birthday — wishing him continued health and happiness. Live long and prosper, my friends.
March 27, 2025 at 4:14 PM
Yesterday, I fondly remembered my dear friend Leonard Nimoy, who would have turned 94. His legacy lives on in our hearts. Just days ago, Bill Shatner celebrated his 94th birthday — wishing him continued health and happiness. Live long and prosper, my friends.
Reposted by Quantitative Biology in Aging and Disease
New publication from the lab! We used a machine learning approach to predict chromatin loop dynamics during human spermatogenesis - and find these structures do not direct gene expression but may drive the positioning of recombination events
bmcbiol.biomedcentral.com/articles/10....
bmcbiol.biomedcentral.com/articles/10....
CTCF-anchored chromatin loop dynamics during human meiosis - BMC Biology
Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and...
bmcbiol.biomedcentral.com
March 24, 2025 at 1:09 PM
New publication from the lab! We used a machine learning approach to predict chromatin loop dynamics during human spermatogenesis - and find these structures do not direct gene expression but may drive the positioning of recombination events
bmcbiol.biomedcentral.com/articles/10....
bmcbiol.biomedcentral.com/articles/10....
Reposted by Quantitative Biology in Aging and Disease
This is great
Canada joins Horizon Europe programme
Canada joins Horizon Europe programme
Canada is joining the growing group of non-EU countries who have associated to the EU's research and innovation programme, Horizon Europe, and will work jointly on large-scale projects tackling our bi...
luxembourg.representation.ec.europa.eu
March 18, 2025 at 6:23 AM
This is great
Reposted by Quantitative Biology in Aging and Disease
TUTORIAL: Our new preprint "Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure" is out @elatorre.bsky.social @edinunilbc.bsky.social @linusschumacher.bsky.social @biologyaging.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 7, 2025 at 1:10 PM
TUTORIAL: Our new preprint "Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure" is out @elatorre.bsky.social @edinunilbc.bsky.social @linusschumacher.bsky.social @biologyaging.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Quantitative Biology in Aging and Disease
This is very disturbing for Equity Diversity and Inclusion in the UK.
www.theguardian.com/business/202...
www.theguardian.com/business/202...
British pharma company GSK pauses diversity work citing Trump orders
London-based FTSE 100 firm reviewing its policies, saying it is obliged to comply because US is its No 1 market
www.theguardian.com
March 5, 2025 at 8:29 AM
This is very disturbing for Equity Diversity and Inclusion in the UK.
www.theguardian.com/business/202...
www.theguardian.com/business/202...
Reposted by Quantitative Biology in Aging and Disease
🔥 New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
February 25, 2025 at 4:24 PM
🔥 New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
🥺
February 22, 2025 at 1:40 AM
🥺
Reposted by Quantitative Biology in Aging and Disease
NEW: Minnesota was just ranked a top state both to retire and to raise a family.
By investing in the things that matter – economic opportunity, health and safety, and strong communities – we’re building the best state for all Minnesotans from childhood through retirement.
By investing in the things that matter – economic opportunity, health and safety, and strong communities – we’re building the best state for all Minnesotans from childhood through retirement.
February 20, 2025 at 11:58 PM
NEW: Minnesota was just ranked a top state both to retire and to raise a family.
By investing in the things that matter – economic opportunity, health and safety, and strong communities – we’re building the best state for all Minnesotans from childhood through retirement.
By investing in the things that matter – economic opportunity, health and safety, and strong communities – we’re building the best state for all Minnesotans from childhood through retirement.
Reposted by Quantitative Biology in Aging and Disease
It was an honor to sign the guest book in the home of Anne Frank.
I was here as a younger man and thought about her life as a dark chapter of history.
Today, I can’t help but think of her story as one of caution. Our world is fragile, and it’s incumbent on us not to break it.
I was here as a younger man and thought about her life as a dark chapter of history.
Today, I can’t help but think of her story as one of caution. Our world is fragile, and it’s incumbent on us not to break it.
February 20, 2025 at 12:36 AM
It was an honor to sign the guest book in the home of Anne Frank.
I was here as a younger man and thought about her life as a dark chapter of history.
Today, I can’t help but think of her story as one of caution. Our world is fragile, and it’s incumbent on us not to break it.
I was here as a younger man and thought about her life as a dark chapter of history.
Today, I can’t help but think of her story as one of caution. Our world is fragile, and it’s incumbent on us not to break it.
Reposted by Quantitative Biology in Aging and Disease
First nuclear weapons management, now this. No one - Democrat or Republican - voted for this kind of incompetence.
NEW: The USDA acknowledged that over the weekend, it accidentally fired "several" agency employees who are working on the federal government's response to the H5N1 avian flu outbreak.
The agency adds it is trying to quickly reverse the firings.
The agency adds it is trying to quickly reverse the firings.
USDA says it accidentally fired officials working on bird flu and is trying to rehire them
In a statement, an Agriculture Department spokesperson told NBC News that officials are "working to swiftly rectify the situation."
www.nbcnews.com
February 19, 2025 at 2:28 AM
First nuclear weapons management, now this. No one - Democrat or Republican - voted for this kind of incompetence.
Reposted by Quantitative Biology in Aging and Disease
A little MYC goes a long way!
Check out this absolute tour de force from colleagues Miryam Müller, Stephanie May, Tom Bird and team who assembled an compendium of liver cancer mouse models mirroring a spectrum of human HCC subtypes:
www.nature.com/articles/s41...
Check out this absolute tour de force from colleagues Miryam Müller, Stephanie May, Tom Bird and team who assembled an compendium of liver cancer mouse models mirroring a spectrum of human HCC subtypes:
www.nature.com/articles/s41...
Human-correlated genetic models identify precision therapy for liver cancer - Nature
As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...
www.nature.com
February 19, 2025 at 4:19 PM
A little MYC goes a long way!
Check out this absolute tour de force from colleagues Miryam Müller, Stephanie May, Tom Bird and team who assembled an compendium of liver cancer mouse models mirroring a spectrum of human HCC subtypes:
www.nature.com/articles/s41...
Check out this absolute tour de force from colleagues Miryam Müller, Stephanie May, Tom Bird and team who assembled an compendium of liver cancer mouse models mirroring a spectrum of human HCC subtypes:
www.nature.com/articles/s41...
Reposted by Quantitative Biology in Aging and Disease
The flying public needs answers. How many FAA personnel were just fired? What positions? And why?
February 17, 2025 at 2:12 PM
The flying public needs answers. How many FAA personnel were just fired? What positions? And why?
Reposted by Quantitative Biology in Aging and Disease
Interested in an early-career fellowship (within 3 years of a PhD)? Want to work at the interface of AI with biology, health or medicine? Contact me if you want support with your application www.bmh.manchester.ac.uk/research/sup...
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
www.bmh.manchester.ac.uk
February 15, 2025 at 11:52 AM
Interested in an early-career fellowship (within 3 years of a PhD)? Want to work at the interface of AI with biology, health or medicine? Contact me if you want support with your application www.bmh.manchester.ac.uk/research/sup...
Reposted by Quantitative Biology in Aging and Disease
New paper. Why do we try to remove increasingly large numbers of lymph nodes in colon cancer surgery? Here we follow up our BJC 2022 paper with ~370K patients in England and USA. Only 9 LNs are required to stage the cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node yield as a surrogate marker for tumour biology and prognosis in colon cancer - British Journal of Cancer
British Journal of Cancer - Lymph node yield as a surrogate marker for tumour biology and prognosis in colon cancer
www.nature.com
February 14, 2025 at 6:44 PM
New paper. Why do we try to remove increasingly large numbers of lymph nodes in colon cancer surgery? Here we follow up our BJC 2022 paper with ~370K patients in England and USA. Only 9 LNs are required to stage the cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Quantitative Biology in Aging and Disease
Do you love software engineering for exciting biological applications, open science,open source, R, Bioconductor, modern web, cloud& ML technologies?
We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
February 14, 2025 at 7:05 AM
Do you love software engineering for exciting biological applications, open science,open source, R, Bioconductor, modern web, cloud& ML technologies?
We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Quantitative Biology in Aging and Disease
Reposted by Quantitative Biology in Aging and Disease
We’re focused on feeding our kids.
Investing in our schools.
Making sure child care is affordable.
Regardless of the chaos unfolding in Washington, we’re making Minnesota the best state for kids to grow up.
Investing in our schools.
Making sure child care is affordable.
Regardless of the chaos unfolding in Washington, we’re making Minnesota the best state for kids to grow up.
February 6, 2025 at 12:24 AM
We’re focused on feeding our kids.
Investing in our schools.
Making sure child care is affordable.
Regardless of the chaos unfolding in Washington, we’re making Minnesota the best state for kids to grow up.
Investing in our schools.
Making sure child care is affordable.
Regardless of the chaos unfolding in Washington, we’re making Minnesota the best state for kids to grow up.
Danke Mutti🙏🏾
January 31, 2025 at 3:20 AM
Danke Mutti🙏🏾
Reposted by Quantitative Biology in Aging and Disease
What DNA variants alter transcription factor (TF) binding affinity? Here, we describe a new workflow baal-nf. We used it to trawl through 6017 ChIP-Seq data sets for 558 TFs and 46 genotyped cell lines, finding 298,783 allele-specific binding sites (ASBs).
www.biorxiv.org/content/10.1...
1/2
www.biorxiv.org/content/10.1...
1/2
January 21, 2025 at 8:02 PM
What DNA variants alter transcription factor (TF) binding affinity? Here, we describe a new workflow baal-nf. We used it to trawl through 6017 ChIP-Seq data sets for 558 TFs and 46 genotyped cell lines, finding 298,783 allele-specific binding sites (ASBs).
www.biorxiv.org/content/10.1...
1/2
www.biorxiv.org/content/10.1...
1/2