Bina Singh
@binasingh.bsky.social
Studying viruses where it matters most- inside the cell, in situ
Postdoc at Umeå University
Postdoc at Umeå University
Reposted by Bina Singh
Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
October 6, 2025 at 8:07 AM
Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
July 11, 2025 at 12:49 PM
Reposted by Bina Singh
Delighted to see our work in press! 🙌🔬🧠
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Proud to share our latest paper. doi.org/10.1016/j.cr...
Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.
Structural biology in tissue is well and truly here!
@rosfrankinst.bsky.social
Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.
Structural biology in tissue is well and truly here!
@rosfrankinst.bsky.social
June 19, 2025 at 9:23 AM
Delighted to see our work in press! 🙌🔬🧠
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.
Excited to see where in tissue structural cell biology goes next 👀!
#liftlaughlove #teamtomo #whopper
Reposted by Bina Singh
"A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis - Nature Communications
There are no vaccines or antivirals available against enterovirus D68. Here, the authors report Jun6504 as a 2C inhibitor and show that it provides broad-spectrum antiviral activity against EV-D68, EV...
www.nature.com
July 4, 2025 at 11:18 AM
"A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bina Singh
structure prediction is not science if not experimentally validated. period
Predicted structures from the AFDB are poor substitutes for experimental structures when training inverse folding NNs. Here, authors show that this is because they are "too perfect", and passing them through a custom-trained AFDB-to-PDB NN helps fix this
threadreaderapp.com/thread/19384...
threadreaderapp.com/thread/19384...
June 27, 2025 at 9:53 PM
structure prediction is not science if not experimentally validated. period
Reposted by Bina Singh
Cryogenic Electron Tomography Redefines Herpesvirus Capsid Assembly Intermediates Inside the Cell Nucleus. www.biorxiv.org/content/10.1101/2025.06.27.661840v1 #cryoem
June 29, 2025 at 12:55 PM
Cryogenic Electron Tomography Redefines Herpesvirus Capsid Assembly Intermediates Inside the Cell Nucleus. www.biorxiv.org/content/10.1101/2025.06.27.661840v1 #cryoem
Just what happens when cryo conditions get too creative: ice contamination feels like sculpture. #CryoFIB #CryoEM #ElectronMicroscopy #MicroscopyArt #MicroscopyMonday
June 16, 2025 at 3:19 PM
Just what happens when cryo conditions get too creative: ice contamination feels like sculpture. #CryoFIB #CryoEM #ElectronMicroscopy #MicroscopyArt #MicroscopyMonday
Reposted by Bina Singh
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET - Nature Communications
This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-e...
www.nature.com
June 15, 2025 at 2:04 PM
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bina Singh
My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social
Please check it out 😊
www.sciencedirect.com/science/arti...
Please check it out 😊
www.sciencedirect.com/science/arti...
From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase
A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report…
www.sciencedirect.com
May 30, 2025 at 12:49 PM
My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social
Please check it out 😊
www.sciencedirect.com/science/arti...
Please check it out 😊
www.sciencedirect.com/science/arti...