Benjamín Walbaum MD
@benjawalbaummd.bsky.social
Medical Oncologist | Research and clinical fellow Hospital Clinic Barcelona | PhD student translational genomics @idipaps | Main focus: young&breast cancer
Reposted by Benjamín Walbaum MD
Intermittent #fasting makes your hair shorter and thicker (if you shave your hair previously), a new study in @cellpress.bsky.social reports www.cell.com/cell/fulltex...
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration
Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands and niche adipocytes, which in turn selectively induces apoptosis of hair follicle stem cells but not epidermal stem cells in the skin.
www.cell.com
December 14, 2024 at 6:07 AM
Intermittent #fasting makes your hair shorter and thicker (if you shave your hair previously), a new study in @cellpress.bsky.social reports www.cell.com/cell/fulltex...
Reposted by Benjamín Walbaum MD
The next big thing in Triple Negative Breast Cancer:
VEGF/PD-1 Bispecifics.
Wonderful discussion by Dr. Thomas Grinda on the prospects.
Several Phase III studies planned.
@oncbrothers.bsky.social @sabcs.bsky.social @oncoalert.bsky.social
VEGF/PD-1 Bispecifics.
Wonderful discussion by Dr. Thomas Grinda on the prospects.
Several Phase III studies planned.
@oncbrothers.bsky.social @sabcs.bsky.social @oncoalert.bsky.social
December 11, 2024 at 10:25 PM
The next big thing in Triple Negative Breast Cancer:
VEGF/PD-1 Bispecifics.
Wonderful discussion by Dr. Thomas Grinda on the prospects.
Several Phase III studies planned.
@oncbrothers.bsky.social @sabcs.bsky.social @oncoalert.bsky.social
VEGF/PD-1 Bispecifics.
Wonderful discussion by Dr. Thomas Grinda on the prospects.
Several Phase III studies planned.
@oncbrothers.bsky.social @sabcs.bsky.social @oncoalert.bsky.social
Reposted by Benjamín Walbaum MD
Dr. Tesch poster looking at TILs in very young women (<40 yrs)
Including all tumor subtypes- TNBC, HR+ and HER-3
TILs vary by recent pregnancy, BRCA status etc.
Here TILs not associated w/ ethnicity
TILs again predict pCR
#SABCS24
@sabcs.bsky.social
@oncoalert.bsky.social
Including all tumor subtypes- TNBC, HR+ and HER-3
TILs vary by recent pregnancy, BRCA status etc.
Here TILs not associated w/ ethnicity
TILs again predict pCR
#SABCS24
@sabcs.bsky.social
@oncoalert.bsky.social
December 11, 2024 at 1:49 PM
Dr. Tesch poster looking at TILs in very young women (<40 yrs)
Including all tumor subtypes- TNBC, HR+ and HER-3
TILs vary by recent pregnancy, BRCA status etc.
Here TILs not associated w/ ethnicity
TILs again predict pCR
#SABCS24
@sabcs.bsky.social
@oncoalert.bsky.social
Including all tumor subtypes- TNBC, HR+ and HER-3
TILs vary by recent pregnancy, BRCA status etc.
Here TILs not associated w/ ethnicity
TILs again predict pCR
#SABCS24
@sabcs.bsky.social
@oncoalert.bsky.social
Reposted by Benjamín Walbaum MD
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
December 11, 2024 at 2:04 PM
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Reposted by Benjamín Walbaum MD
#SABCS24 #bcsm #OncSky #SurgSky
Dr. R Hills: Meta-analysis of 4 older RCTs of immediate vs deferred surgery in women w/ operable ER+ #breastcancer receiving adjuvant tamoxifen. Immed surgery ⬇️ local progression, distant mets, & BC mortality. NNT <7 to prevent 1 BC death.
cc @oncoalert.bsky.social
Dr. R Hills: Meta-analysis of 4 older RCTs of immediate vs deferred surgery in women w/ operable ER+ #breastcancer receiving adjuvant tamoxifen. Immed surgery ⬇️ local progression, distant mets, & BC mortality. NNT <7 to prevent 1 BC death.
cc @oncoalert.bsky.social
December 11, 2024 at 12:24 AM
#SABCS24 #bcsm #OncSky #SurgSky
Dr. R Hills: Meta-analysis of 4 older RCTs of immediate vs deferred surgery in women w/ operable ER+ #breastcancer receiving adjuvant tamoxifen. Immed surgery ⬇️ local progression, distant mets, & BC mortality. NNT <7 to prevent 1 BC death.
cc @oncoalert.bsky.social
Dr. R Hills: Meta-analysis of 4 older RCTs of immediate vs deferred surgery in women w/ operable ER+ #breastcancer receiving adjuvant tamoxifen. Immed surgery ⬇️ local progression, distant mets, & BC mortality. NNT <7 to prevent 1 BC death.
cc @oncoalert.bsky.social
Reposted by Benjamín Walbaum MD
Do systemic responses to ICI (eg irAEs) associate w outcomes?
Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al
Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al
Impact of cycle 1 irAEs on ICI outcomes:
- 683pts from SWOG DART trial
- g1-2 irAEs = ⬆️OS HR 0.61 p < 0.001
- g3+ irAEs = ⬇️OS HR 1.41 p= .025
- g1-2 derm irAE = ⬆️OS v other g1-2 irAE HR 0.67 p=0.002
Congrats @eladsharonmd.bsky.social @oncoalert.bsky.social
academic.oup.com/jnci/advance...
- 683pts from SWOG DART trial
- g1-2 irAEs = ⬆️OS HR 0.61 p < 0.001
- g3+ irAEs = ⬇️OS HR 1.41 p= .025
- g1-2 derm irAE = ⬆️OS v other g1-2 irAE HR 0.67 p=0.002
Congrats @eladsharonmd.bsky.social @oncoalert.bsky.social
academic.oup.com/jnci/advance...
First Cycle Toxicity and Survival in Patients with Rare Cancers Treated with Checkpoint Inhibitors
AbstractBackground. Associations between immune-related adverse events (irAEs) from checkpoint inhibitor therapy and outcomes have been previously evaluate
academic.oup.com
November 30, 2024 at 6:44 PM
Do systemic responses to ICI (eg irAEs) associate w outcomes?
Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al
Nice use of existing basket studies by @pateloncology.bsky.social @eladsharonmd.bsky.social Razelle Kurzrock et al
Reposted by Benjamín Walbaum MD
Isolated tumor cells (ITCs) after neoadj can’t chemotherapy have frequently been considered positive lymph nodes when considering axillary management and adjuvant therapy.
Important global study that suggests, as @maryamlustberg.bsky.social notes, less may be more!
#bcsm
Important global study that suggests, as @maryamlustberg.bsky.social notes, less may be more!
#bcsm
November 29, 2024 at 8:45 PM
Isolated tumor cells (ITCs) after neoadj can’t chemotherapy have frequently been considered positive lymph nodes when considering axillary management and adjuvant therapy.
Important global study that suggests, as @maryamlustberg.bsky.social notes, less may be more!
#bcsm
Important global study that suggests, as @maryamlustberg.bsky.social notes, less may be more!
#bcsm
Reposted by Benjamín Walbaum MD
November 29, 2024 at 3:39 PM
Reposted by Benjamín Walbaum MD
You are what you consume. Screen time limits are the future.
“Together, the findings suggest that the information sought reflects mental state and shapes it, creating a loop that may perpetuate mental health problems.”
“Together, the findings suggest that the information sought reflects mental state and shapes it, creating a loop that may perpetuate mental health problems.”
A paper in Nature Human Behaviour reports that web-browsing reflects and affects mental health. Poorer mental health leads to more negative consumption, which in turn worsens mood. Highlighting webpage emotional impacts reduced negative browsing and improved mood. https://go.nature.com/3CExy2E 🧪
November 27, 2024 at 3:37 PM
You are what you consume. Screen time limits are the future.
“Together, the findings suggest that the information sought reflects mental state and shapes it, creating a loop that may perpetuate mental health problems.”
“Together, the findings suggest that the information sought reflects mental state and shapes it, creating a loop that may perpetuate mental health problems.”
Reposted by Benjamín Walbaum MD
Now in JNCI “Pts w stage 1 & 2 breast cancer have excellent prognosis, yet account for >60% breast cancer–specific death due to large #. To ⬇️ breast cancer death, strategies neededed to identify,treat pts w/early stage BC w/ risk for recurrence” @oncoalert.bsky.social
doi.org/10.1093/jnci...
doi.org/10.1093/jnci...
Trends in breast cancer–specific death by clinical stage at diagnoses between 2000 and 2017
AbstractBackground. Approximately 40 000 individuals die from metastatic breast cancer each year. We examined what fractions of annual breast cancer–specif
doi.org
November 24, 2024 at 12:47 PM
Now in JNCI “Pts w stage 1 & 2 breast cancer have excellent prognosis, yet account for >60% breast cancer–specific death due to large #. To ⬇️ breast cancer death, strategies neededed to identify,treat pts w/early stage BC w/ risk for recurrence” @oncoalert.bsky.social
doi.org/10.1093/jnci...
doi.org/10.1093/jnci...
Reposted by Benjamín Walbaum MD
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells - Nature Reviews Cancer
In this Review, Rabas et al. describe the mechanisms by which primary tumours precondition distal organs to favour metastatic colonization — a limiting step of metastasis — and dis...
www.nature.com
November 24, 2024 at 12:21 PM
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Benjamín Walbaum MD
Reposted by Benjamín Walbaum MD
There is not enough evidence for poor performance of cdk4/6i (abema in MonarchE) in patients with BRCA pathogenic mutations. These patients still
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
November 23, 2024 at 6:39 AM
There is not enough evidence for poor performance of cdk4/6i (abema in MonarchE) in patients with BRCA pathogenic mutations. These patients still
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
deserve adj cdk4/6i if they meet criteria. Nadia Harbeck discussing this topic in Bogota 🇨🇴
Reposted by Benjamín Walbaum MD
Correlative analysis of GeparNuevo #TNBC neoadj clinical trial by Denkert et al:
➡️Expression analyses of tumor biopsies at 3 time points
➡️Confirm role of immune & prolif signatures
➡️Stromal signature assoc w immunotherapy resistance
@oncoalert.bsky.social #BCSM
www.cell.com/cell-reports...
➡️Expression analyses of tumor biopsies at 3 time points
➡️Confirm role of immune & prolif signatures
➡️Stromal signature assoc w immunotherapy resistance
@oncoalert.bsky.social #BCSM
www.cell.com/cell-reports...
Molecular adaptation to neoadjuvant immunotherapy in triple-negative breast cancer
Denkert et al. evaluate the longitudinal changes in tumor tissue of triple-negative
breast cancer in a clinical trial cohort treated with neoadjuvant immunotherapy plus
chemotherapy. The role of diffe...
www.cell.com
November 21, 2024 at 2:15 PM
Correlative analysis of GeparNuevo #TNBC neoadj clinical trial by Denkert et al:
➡️Expression analyses of tumor biopsies at 3 time points
➡️Confirm role of immune & prolif signatures
➡️Stromal signature assoc w immunotherapy resistance
@oncoalert.bsky.social #BCSM
www.cell.com/cell-reports...
➡️Expression analyses of tumor biopsies at 3 time points
➡️Confirm role of immune & prolif signatures
➡️Stromal signature assoc w immunotherapy resistance
@oncoalert.bsky.social #BCSM
www.cell.com/cell-reports...
Reposted by Benjamín Walbaum MD
Very interesting focus on senescence in Nat Rev Mol Cell Biol! @natureportfolio.bsky.social . Concepts, protocols, therapies and many more.. www.nature.com/collections/... @oncosky 🧪
Cell senescence
Cell senescence — a state of irreversible cell-growth arrest — has important physiological functions and is a key driver of ageing.
www.nature.com
November 21, 2024 at 7:40 AM
Very interesting focus on senescence in Nat Rev Mol Cell Biol! @natureportfolio.bsky.social . Concepts, protocols, therapies and many more.. www.nature.com/collections/... @oncosky 🧪
Reposted by Benjamín Walbaum MD
I am truly grateful for the opportunity to bring together with this paper the amazing people I have had the privilege of working with in the field of #immunotherapy. #bcsm #breastcancer
#OpenAccess
www.cancertreatmentreviews.com/article/S030...
#OpenAccess
www.cancertreatmentreviews.com/article/S030...
November 21, 2024 at 1:47 AM
I am truly grateful for the opportunity to bring together with this paper the amazing people I have had the privilege of working with in the field of #immunotherapy. #bcsm #breastcancer
#OpenAccess
www.cancertreatmentreviews.com/article/S030...
#OpenAccess
www.cancertreatmentreviews.com/article/S030...
Reposted by Benjamín Walbaum MD
November 21, 2024 at 2:12 AM
Reposted by Benjamín Walbaum MD
Updated treatment algorithms for breast cancer now include adjuvant ribociclib and inavolisib, along with key trial names. Thrilled to see we're truly running out of space in HR+ disease—progress is here, with much more to come for all breast cancer subtypes!
November 17, 2024 at 11:04 PM
Updated treatment algorithms for breast cancer now include adjuvant ribociclib and inavolisib, along with key trial names. Thrilled to see we're truly running out of space in HR+ disease—progress is here, with much more to come for all breast cancer subtypes!
Reposted by Benjamín Walbaum MD
Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!
November 17, 2024 at 8:01 PM
Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!
Reposted by Benjamín Walbaum MD
#Oncology
NEW Review explores the marked increase in #cancer in young people over the last few decades. Includes multiple hypotheses about why we’re seeing this & methods to test them. #OncoSky #MedSky #bcsm #crcsm #ayacsm #melsm #kcsm #pancsm #thyroidcancer
www.cell.com/action/showP...
NEW Review explores the marked increase in #cancer in young people over the last few decades. Includes multiple hypotheses about why we’re seeing this & methods to test them. #OncoSky #MedSky #bcsm #crcsm #ayacsm #melsm #kcsm #pancsm #thyroidcancer
www.cell.com/action/showP...
November 12, 2024 at 12:40 PM
Reposted by Benjamín Walbaum MD
Hello friends! Smells like clean air in here.
Let’s make it grow! 🦋
Let’s make it grow! 🦋
@ptarantinomd.bsky.social has arrived everyone! Let the #bcsm discussions begin!!! @stage4kelly.bsky.social @drsgraff.bsky.social @erikahamilton9.bsky.social @drsarahsammons.bsky.social @janicetnbcmets.bsky.social
November 15, 2024 at 7:28 PM
Hello friends! Smells like clean air in here.
Let’s make it grow! 🦋
Let’s make it grow! 🦋
Reposted by Benjamín Walbaum MD
#DrugDevelopment
“Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯
#OncoSky #MedSky #bcsm
jamanetwork.com/journals/jam...
“Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯
#OncoSky #MedSky #bcsm
jamanetwork.com/journals/jam...
Heterogeneity of Residual Disease After Neoadjuvant Systemic Therapy in Breast Cancer
This review analyzes the heterogeneity of residual disease after neoadjuvant systemic therapy in patients with breast cancer.
jamanetwork.com
November 12, 2024 at 12:37 PM
#DrugDevelopment
“Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯
#OncoSky #MedSky #bcsm
jamanetwork.com/journals/jam...
“Uncovering the anatomic & biological intricacies of residual disease will allow for ⬆️ precision in postneoadjuvant treatments, moving beyond the binary paradigm of RD vs path CR, toward more tailored rescue strategies.” 💯
#OncoSky #MedSky #bcsm
jamanetwork.com/journals/jam...