Ben Dewals
@bendewals.bsky.social
Immuno-parasitology lab - Professor @ULiege
We study helminths, type 2 immunity and its regulation, also looking at immune changes impacting viral (co)infections or vaccination.
We study helminths, type 2 immunity and its regulation, also looking at immune changes impacting viral (co)infections or vaccination.
Pinned
Ben Dewals
@bendewals.bsky.social
· Nov 28
First Bluesky 🦋 post and the occasion to share the most recent photo of the lab members! We'll have exciting news on helminths, IL-4 and CD8 T cell responses to share soon! 😁
Reposted by Ben Dewals
Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 19, 2025 at 7:53 PM
Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!
Reposted by Ben Dewals
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 22, 2025 at 9:20 AM
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Reposted by Ben Dewals
Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...
Hallmarks and metabolic regulation of type 2 activated human lung macrophages
Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Ou...
www.biorxiv.org
March 3, 2025 at 3:42 PM
Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...
Reposted by Ben Dewals
ICYMI: earlier this month in #Science #Immunology, bendewals.bsky.social & colleagues reported that #CD22 expression by virtual #MemoryTCells ( #TVM ) inhibits their expansion in response to #IL4 in the context of #helminth infection !
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.
www.science.org
February 24, 2025 at 4:40 PM
ICYMI: earlier this month in #Science #Immunology, bendewals.bsky.social & colleagues reported that #CD22 expression by virtual #MemoryTCells ( #TVM ) inhibits their expansion in response to #IL4 in the context of #helminth infection !
Reposted by Ben Dewals
Researchers have just identified a previously unknown mechanism that helps regulate the body's immune response to parasitic infections. This discovery could pave the way for new treatments to better control infections and inflammatory diseases. @science.org
www.news.uliege.be/cms/c_203779...
www.news.uliege.be/cms/c_203779...
An unexpected mechanism regulates the immune response during parasitic infections
A discovery by ULiège researchers on Virtual Memory T Cells and their activation during parasitic infections in mice
www.news.uliege.be
February 10, 2025 at 8:40 AM
Researchers have just identified a previously unknown mechanism that helps regulate the body's immune response to parasitic infections. This discovery could pave the way for new treatments to better control infections and inflammatory diseases. @science.org
www.news.uliege.be/cms/c_203779...
www.news.uliege.be/cms/c_203779...
Reposted by Ben Dewals
Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.
www.science.org
February 7, 2025 at 10:00 PM
Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.
Reposted by Ben Dewals
So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social
Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots!
science.org/toc/sciimmunol/10/104
science.org/toc/sciimmunol/10/104
February 7, 2025 at 10:09 PM
So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social
Reposted by Ben Dewals
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 7, 2025 at 11:55 PM
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social
Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots!
science.org/toc/sciimmunol/10/104
science.org/toc/sciimmunol/10/104
February 7, 2025 at 10:09 PM
So nice to see our paper on CD22 regulating #TVMcell during #helminth infection out today 🤗 ! Thanks #Science#Immunology and great editorial work by @hannah-isles.bsky.social
Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.
www.science.org
February 7, 2025 at 10:00 PM
Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.
Reposted by Ben Dewals
Reposted by Ben Dewals
Interested in immune responses to parasites? Mark Viney, James Hewitson and I have an exciting PhD project available : BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses
Do get in touch if interested!
urldefense.com/v3/__https:/...
Do get in touch if interested!
urldefense.com/v3/__https:/...
BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses at University of Liverpool, listed on FindAPhD.com
urldefense.com
December 19, 2024 at 8:33 AM
Interested in immune responses to parasites? Mark Viney, James Hewitson and I have an exciting PhD project available : BBSRC NWD CASE: The role of co-infections in modulating anti-nematode immune responses
Do get in touch if interested!
urldefense.com/v3/__https:/...
Do get in touch if interested!
urldefense.com/v3/__https:/...
Reposted by Ben Dewals
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
Research Fellow, Medicine, Medical Sciences & Nutrition (IMS301R) | The University of Aberdeen
www.abdn.ac.uk
December 5, 2024 at 10:15 AM
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
Reposted by Ben Dewals
Prospective PhD students...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - MRC DTP in Precision Medicine - Supervisors and Projects - Projects 2025 - Projects 25 - Matt BerrimanSearch iconClose men...
www.gla.ac.uk
December 3, 2024 at 6:16 PM
Prospective PhD students...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...
Reposted by Ben Dewals
We have a great line up and we are super excited by all the abstracts we have recieved!
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
https://hubs.la/Q02ZKxQV0
t.co
November 30, 2024 at 9:17 PM
We have a great line up and we are super excited by all the abstracts we have recieved!
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Reposted by Ben Dewals
Interested in #mucosalimmunology and the #microbiome? We are looking for a postdoc to join our team at the #RIMUHC at McGill University in Montreal, Canada
Reply here or email me at irah.king@mcgill.ca for more info.
Reply here or email me at irah.king@mcgill.ca for more info.
November 23, 2024 at 7:49 PM
Interested in #mucosalimmunology and the #microbiome? We are looking for a postdoc to join our team at the #RIMUHC at McGill University in Montreal, Canada
Reply here or email me at irah.king@mcgill.ca for more info.
Reply here or email me at irah.king@mcgill.ca for more info.
Reposted by Ben Dewals
Check out this landmark paper, hot off the press from Iliyan Iliev’s group (not on Bluesky, yet). www.nature.com/articles/s41... Very grateful to be a part of it!
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
www.nature.com
November 27, 2024 at 8:06 PM
Check out this landmark paper, hot off the press from Iliyan Iliev’s group (not on Bluesky, yet). www.nature.com/articles/s41... Very grateful to be a part of it!
First Bluesky 🦋 post and the occasion to share the most recent photo of the lab members! We'll have exciting news on helminths, IL-4 and CD8 T cell responses to share soon! 😁
November 28, 2024 at 8:14 PM
First Bluesky 🦋 post and the occasion to share the most recent photo of the lab members! We'll have exciting news on helminths, IL-4 and CD8 T cell responses to share soon! 😁