Ben Jenkins
@ben-j-jenkins.bsky.social
Imiwnolegydd Cymraeg 🏴 • Post Doc @ Swansea University in Nick Jones' group • Interested in #immunometabolism and disease, currently focussing on T cells
Pinned
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
Pleased to be able to share our latest work on mitochondrial ABHD11 and its role in regulating T-cell function.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Reposted by Ben Jenkins
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 3, 2025 at 11:18 PM
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pleased to be able to share our latest work on mitochondrial ABHD11 and its role in regulating T-cell function.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 6:35 PM
Pleased to be able to share our latest work on mitochondrial ABHD11 and its role in regulating T-cell function.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Really cool to get to co-author this one with my sister as well.
Massive thank you as always to everyone who's been involved with the project.
Reposted by Ben Jenkins
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben Jenkins
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 21, 2025 at 9:37 AM
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ben Jenkins
Secondly, PhD student Emma Lucas and myself contributed towards how metabolism shapes relapsed/refractory T-cell acute lymphoblastic leukaemia, led by João Barata and colleagues from the T-ALL special interest group
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia - Leukemia
Leukemia - Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
www.nature.com
August 14, 2025 at 7:26 PM
Secondly, PhD student Emma Lucas and myself contributed towards how metabolism shapes relapsed/refractory T-cell acute lymphoblastic leukaemia, led by João Barata and colleagues from the T-ALL special interest group
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben Jenkins
The first takes a look at repurposing metabolic drugs as anti-inflammatory agents with @andyhogan82.bsky.social @ben-j-jenkins.bsky.social @obesityimmunology.bsky.social
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Repurposing metabolic drugs as anti-inflammatory agents
Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory
phenotype, with each underpinning the other. Over the past decade, new classes of
drug, such as glucagon-like...
www.cell.com
August 14, 2025 at 7:26 PM
The first takes a look at repurposing metabolic drugs as anti-inflammatory agents with @andyhogan82.bsky.social @ben-j-jenkins.bsky.social @obesityimmunology.bsky.social
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Reposted by Ben Jenkins
Really pleased to share two review articles the lab has been involved in lately 👇🏻
Thanks for the involvement!
Thanks for the involvement!
August 14, 2025 at 7:26 PM
Really pleased to share two review articles the lab has been involved in lately 👇🏻
Thanks for the involvement!
Thanks for the involvement!
Reposted by Ben Jenkins
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
August 13, 2025 at 9:21 PM
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
Reposted by Ben Jenkins
First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
Chronic inflammation in autoimmunity is driven by T cell hyperactivation. This unregulated response to self is fuelled by heightened metabolic programmes, which offers a promising new direction to unc...
www.biorxiv.org
March 20, 2025 at 8:46 AM
First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...