Wonderful stuff. Congratulations 🎊

Awesome stuff 👏

These mechanisms explain why one of the deadliest toxins is also a highly successful therapeutic protein.

After endocytosis, the acidification of the vesicle lumen acts as a signal for Botox to adopt It only adopt translocation-competent state and to enter the host cytosol.

The Botox in free state is highly dynamic, but upon binding to SV2B receptor, it attains an open conformation, preventing premature entry into the host cell.

This work highlights how biological toxins—one of nature’s most finely evolved molecules—function with sophistication and accuracy. They can inspire the development of new innovative tools & therapeutics. #Science #Evolution #Technology