Bartomeu Colom
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bartomeucolom.bsky.social
Bartomeu Colom
@bartomeucolom.bsky.social
200 followers 210 following 35 posts
Senior Scientist @altoslabs, previously @sangerinstitute.bsky.social. Stem cells, somatic mutations & cell competition in aging and early cancer. Views are my own.
https://scholar.google.com/citations?hl=en&user=o5vRhIAAAAAJ
Posts Replies Media Videos
bartomeucolom.bsky.social
'Mechanisms of cellular fitness and cell competition: Towards an integrated view'
www.sciencedirect.com/science/arti...
October 15, 2025 at 10:11 AM
bartomeucolom.bsky.social
'Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer'
www.nature.com/articles/s41...
September 12, 2025 at 10:33 AM
bartomeucolom.bsky.social
'Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength'
www.nature.com/articles/s43...
Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength - Nature Aging
With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken m...
www.nature.com
September 4, 2025 at 2:03 PM
bartomeucolom.bsky.social
'The Somatic Mosaicism across Human Tissues Network'
www.nature.com/articles/s41...
July 10, 2025 at 10:19 AM
bartomeucolom.bsky.social
'Cross-tissue multicellular coordination and its rewiring in cancer'
www.nature.com/articles/s41...
July 10, 2025 at 8:16 AM
bartomeucolom.bsky.social
"Cell cycle duration determines oncogenic transformation capacity"
www.nature.com/articles/s41...
May 29, 2025 at 10:20 AM
bartomeucolom.bsky.social
'Neural cell competition sculpting brain from cradle to grave'
academic.oup.com/nsr/article/...
May 6, 2025 at 7:45 AM
bartomeucolom.bsky.social
'Geographic and age variations in mutational processes in colorectal cancer'
www.nature.com/articles/s41...
April 24, 2025 at 8:24 AM
bartomeucolom.bsky.social
'Emergence and properties of adult mammalian epidermal stem cells'
www.sciencedirect.com/science/arti...
March 27, 2025 at 8:42 AM
bartomeucolom.bsky.social
'Clonal driver neoantigen loss under EGFR TKI and immune selection pressures'
www.nature.com/articles/s41...
March 26, 2025 at 4:11 PM
Reposted by Bartomeu Colom
epimechfc.bsky.social
Hundsdorfer, L., Muenkel, M., Aparicio-Yuste, R., ..., Mostowy, S., & Bastounis, E. E. (2025). ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells. Cell reports, 44(1), 115193. #EpithelialMechanics
buff.ly/g0GPOtr
March 26, 2025 at 10:00 AM
Reposted by Bartomeu Colom
mariapalcolea.bsky.social
🛫You won’t want to miss us in stunning Malta!🌴🏖️ Get ready to be inspired at the STEM CELLS & CANCER conference. INCREDIBLE LINE-UP of speakers!

🎙️Cedric Blanpain @cedric-blanpain.bsky.social
🎙️Peter Dirks
🎙️Catriona Jamieson… and more 🧵

📅 September 28, 2025
🔗 bit.ly/49sCfJp

@fusionconf.bsky.social
mariapalcolea.bsky.social Maria Alcolea @mariapalcolea.bsky.social · Jan 22
✈️Join us in paradise!

The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬

World-leading experts will share their exciting science.

🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025

bit.ly/49sCfJp
March 25, 2025 at 11:48 AM
bartomeucolom.bsky.social
'Translating premalignant biology to accelerate non-small-cell lung cancer interception'
www.nature.com/articles/s41...
March 24, 2025 at 3:39 PM
bartomeucolom.bsky.social
'The end of the genetic paradigm of cancer'
journals.plos.org/plosbiology/...
March 21, 2025 at 1:26 PM
Reposted by Bartomeu Colom
drusqui.bsky.social
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
rdcu.be
March 19, 2025 at 9:28 PM
bartomeucolom.bsky.social
'Cancer evolution: from Darwin to the Extended Evolutionary Synthesis'
www.cell.com/trends/cance...
March 11, 2025 at 4:11 PM
bartomeucolom.bsky.social
'Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis'
www.cell.com/cancer-cell/...
March 11, 2025 at 9:06 AM
bartomeucolom.bsky.social
'The complex interplay between aging and cancer'
www.nature.com/articles/s43...
The complex interplay between aging and cancer - Nature Aging
This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and dysregulated immunity ...
www.nature.com
March 7, 2025 at 8:51 AM
bartomeucolom.bsky.social
'Clonal dynamics and somatic evolution of haematopoiesis in mouse'
www.nature.com/articles/s41...
March 6, 2025 at 9:31 AM
bartomeucolom.bsky.social
'Exposomal determinants of non-geneticplasticity in tumor initiation'
www.cell.com/trends/cance...
March 3, 2025 at 10:26 AM
bartomeucolom.bsky.social
'Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation'
www.sciencedirect.com/science/arti...
February 28, 2025 at 9:03 AM
Reposted by Bartomeu Colom
gomeslab.bsky.social
So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...
www.biorxiv.org
February 3, 2025 at 7:13 PM
Reposted by Bartomeu Colom
thefuchslab.bsky.social
Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
www.nature.com
January 29, 2025 at 5:00 PM
Reposted by Bartomeu Colom
mariapalcolea.bsky.social
✈️Join us in paradise!

The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬

World-leading experts will share their exciting science.

🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025

bit.ly/49sCfJp
January 22, 2025 at 5:34 PM
Reposted by Bartomeu Colom
imartincorena.bsky.social
A nice article covering some of the surprises in the field of somatic mosaicism in the last decade. As I say there: "Judging by the discoveries that we are making at the moment, the journey has only just started. I expect many surprises in the next few years." knowablemagazine.org/content/arti...
We are all mosaics
Picture your body: It’s a collection of cells carrying thousands of genetic mistakes accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.
knowablemagazine.org
January 10, 2025 at 9:59 AM