Ben Allsup
@ballsup.bsky.social
Reposted by Ben Allsup
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages
Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.
www.science.org
March 27, 2025 at 7:13 AM
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ben Allsup
Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇
January 28, 2025 at 5:25 PM
Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇
Reposted by Ben Allsup
What a cool study and a powerful demonstration that Tuberculosis is largely a disease of poverty. In Brazil a large scale intervention which provided cash monthly to families living in poverty led to profound reductions in TB cases. Up to 50% among the poorest groups.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort - Nature Medicine
Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among ...
www.nature.com
January 3, 2025 at 8:36 PM
What a cool study and a powerful demonstration that Tuberculosis is largely a disease of poverty. In Brazil a large scale intervention which provided cash monthly to families living in poverty led to profound reductions in TB cases. Up to 50% among the poorest groups.
www.nature.com/articles/s41...
www.nature.com/articles/s41...