@b-iologist.bsky.social
Reposted
Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation! doi.org/10.1038/s415...
#pDC #APC #TNF #IFN-I #immunosky
#pDC #APC #TNF #IFN-I #immunosky
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
doi.org
August 16, 2025 at 1:27 AM
Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation! doi.org/10.1038/s415...
#pDC #APC #TNF #IFN-I #immunosky
#pDC #APC #TNF #IFN-I #immunosky
June 30, 2025 at 6:45 PM
Reposted
Happy to share a preprint from the Angelo lab many years in the making. Read on for a saga of multiplexed imaging, immunometabolism, and TB granulomas with some fun side quests into the realms of geographical information sciences and transcriptomics… (1/20) doi.org/10.1101/2025...
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We prev...
doi.org
February 24, 2025 at 10:16 PM
Happy to share a preprint from the Angelo lab many years in the making. Read on for a saga of multiplexed imaging, immunometabolism, and TB granulomas with some fun side quests into the realms of geographical information sciences and transcriptomics… (1/20) doi.org/10.1101/2025...
Reposted
I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) 🧪🧬 🖥️ #AcademicSky #MLSky #ImmunoSky www.biorxiv.org/content/10.1...
Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition
Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the deter...
www.biorxiv.org
January 29, 2025 at 4:17 PM
I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) 🧪🧬 🖥️ #AcademicSky #MLSky #ImmunoSky www.biorxiv.org/content/10.1...