Rebeca Arroyo
@rebecaarroyo.bsky.social
Immunologist || Exploring the myeloid-CAR T network || Stanford
Don't miss the morphological transformation pDC → tDC → cDC2 on the cover of Nature Immunology!
www.nature.com/ni/volumes/2...
www.nature.com/ni/volumes/2...
September 2, 2025 at 4:11 PM
Don't miss the morphological transformation pDC → tDC → cDC2 on the cover of Nature Immunology!
www.nature.com/ni/volumes/2...
www.nature.com/ni/volumes/2...
Reposted by Rebeca Arroyo
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
rdcu.be
August 20, 2025 at 8:33 PM
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
www.nature.com
August 16, 2025 at 1:42 AM
Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation! doi.org/10.1038/s415...
#pDC #APC #TNF #IFN-I #immunosky
#pDC #APC #TNF #IFN-I #immunosky
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
doi.org
August 16, 2025 at 1:27 AM
Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation! doi.org/10.1038/s415...
#pDC #APC #TNF #IFN-I #immunosky
#pDC #APC #TNF #IFN-I #immunosky