Azadeh Shahsavar
LightNews LightNews
banner
azadeh-shahsavar.bsky.social
Azadeh Shahsavar
@azadeh-shahsavar.bsky.social
1.3K followers 640 following 35 posts
Structural biologists | Associate professor at the University of Copenhagen | EMBL-Hamburg, DANDRITE AU, and MolBiolAU Alumni.
Posts Replies Media Videos
Reposted by Azadeh Shahsavar
unglam.bsky.social
🚨My new team at @ipbstoulouse.bsky.social in France currently have an open, fully-funded PhD position 🧑‍🔬👩‍🔬to study membrane proteins & transporters of therapeutic interest using cryo-EM & biophysics.🧊🔬🦠

#StructuralBiology #MicroSky

Please share 🤝
For more details 👇
May 21, 2025 at 9:30 AM
Reposted by Azadeh Shahsavar
interactivefly.bsky.social
Pedersen, C. N., Yang, F., Ita, S., ..., Mortensen, O. V., Nissen, P., Shahsavar, A. (2024). Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J Neurochem, onlinelibrary.wiley.com/doi/10.1111/...
Cryo‐EM structure of the dopamine transporter with a novel atypical non‐competitive inhibitor bound to the orthosteric site
Atypical inhibitors of dopamine transporter lack the rewarding effects of psychostimulants and offer a promising strategy for the treatment of drug use disorders. In this study, we present the cryo-e...
onlinelibrary.wiley.com
May 9, 2025 at 3:43 PM
azadeh-shahsavar.bsky.social
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social

www.biorxiv.org/content/10.1...
Structural insights into allosteric mechanism of glycine transporter-mediated analgesia
Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...
www.biorxiv.org
April 24, 2025 at 8:14 PM
azadeh-shahsavar.bsky.social
We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state!
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Structural basis for selective inhibition of human GABA transporter GAT3
The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...
www.biorxiv.org
March 29, 2025 at 2:12 PM
azadeh-shahsavar.bsky.social
Happy Nowruz! Happy first day of spring 🌺
March 20, 2025 at 7:50 AM
Reposted by Azadeh Shahsavar
nadia-izadi.bsky.social
📣 It’s my great pleasure to host @azadeh-shahsavar.bsky.social from the University of Copenhagen, in our department @pasteur.fr tomorrow.
Very much looking forward to her talk 👇
February 10, 2025 at 11:19 AM
Reposted by Azadeh Shahsavar
arianebriegel.bsky.social
We are looking for a conference location for up to about 160 people: consideration on accessibility (most attendees will have to travel from US and Europe), affordability (low cost for students and postdocs), and mild climate ( meeting in January). Any Ideas you can share? 🙏
October 20, 2023 at 5:10 AM
azadeh-shahsavar.bsky.social
#HiSciSky! I'm a #NewPI at the University of Copenhagen. My team and I study amino acid and neurotransmitter transporters using structural biology to exploit their therapeutic potential.

#CryoEM #SerialCrystallography #SSX
#MembraneProteins
#AcademicSky #PsychSky
#neuroskyence
October 4, 2023 at 7:19 AM