Azadeh Shahsavar
@azadeh-shahsavar.bsky.social
Structural biologists | Associate professor at the University of Copenhagen | EMBL-Hamburg, DANDRITE AU, and MolBiolAU Alumni.
We have determined the first #cryoEM structures of human GlyT2 bound to a potent pseudo-irreversible inhibitor (ORG25543) that failed in pre-clinical studies, a novel and reversible inhibitor (RPI-GLYT2-82), and in the substrate-free state.
April 24, 2025 at 8:14 PM
We have determined the first #cryoEM structures of human GlyT2 bound to a potent pseudo-irreversible inhibitor (ORG25543) that failed in pre-clinical studies, a novel and reversible inhibitor (RPI-GLYT2-82), and in the substrate-free state.
Our inhibitor-bound inward-open GAT3 reveals the binding mode of SR-THAP and the structural determinants of selectivity. Our GABA-bound inward-occluded GAT3 reveals ion coordination and substrate recognition network with exciting distinction to that previously observed for the GAT1 subtype.
March 29, 2025 at 2:12 PM
Our inhibitor-bound inward-open GAT3 reveals the binding mode of SR-THAP and the structural determinants of selectivity. Our GABA-bound inward-occluded GAT3 reveals ion coordination and substrate recognition network with exciting distinction to that previously observed for the GAT1 subtype.
Happy Nowruz! Happy first day of spring 🌺
March 20, 2025 at 7:50 AM
Happy Nowruz! Happy first day of spring 🌺
I mean… just saw this:
March 14, 2025 at 7:53 PM
I mean… just saw this: