Axel Montagne
@axelmontagne.bsky.social
Senior Lecturer & Group Leader @UKDRI @EdinburghUni, @The_MRC CDA Fellow | @USC & @Universite_Caen alumnus | Vascular, Imaging & Dementia 🧠 | Lab - @montagnelab
Reposted by Axel Montagne
Reposted by Axel Montagne
The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier.
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
The blood–brain barrier
Here, Audrey Chagnot and Axel Montagne discuss the structural and functional features
of the blood–brain barrier and the association of its disruption with various pathologies.
www.cell.com
October 30, 2025 at 4:54 PM
The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier.
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Excited to share our Current Biology Primer written with Dr. Audrey Chagnot in the Brain-Body Interactions special issue!
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
The blood–brain barrier
In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coord…
shorturl.at
October 20, 2025 at 7:26 PM
Excited to share our Current Biology Primer written with Dr. Audrey Chagnot in the Brain-Body Interactions special issue!
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.
@ukdri.ac.uk @thebhf.bsky.social
shorturl.at/NNc57
Reposted by Axel Montagne
Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social
@CRC1366
@erc.europa.eu @immunosens.bsky.social
October 14, 2025 at 5:16 PM
Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social
@CRC1366
@erc.europa.eu @immunosens.bsky.social
Reposted by Axel Montagne
🌟 New job opportunity 🌟
Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias.
Find out more and apply via the link
🗓️ Apply by 22 October 2025
📌 Full details 👉 tinyurl.com/22y73642
Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias.
Find out more and apply via the link
🗓️ Apply by 22 October 2025
📌 Full details 👉 tinyurl.com/22y73642
October 6, 2025 at 7:44 AM
🌟 New job opportunity 🌟
Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias.
Find out more and apply via the link
🗓️ Apply by 22 October 2025
📌 Full details 👉 tinyurl.com/22y73642
Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias.
Find out more and apply via the link
🗓️ Apply by 22 October 2025
📌 Full details 👉 tinyurl.com/22y73642
Reposted by Axel Montagne
Congratulations to Dr Maura Malpetti (UK DRI at Cambridge), who has won the 2025 European Young Researcher Award from the Fondation Recherche Alzheimer in France. 🎉👏
Read the full story 👉 tinyurl.com/243s9tuf
Read the full story 👉 tinyurl.com/243s9tuf
September 25, 2025 at 3:50 PM
Congratulations to Dr Maura Malpetti (UK DRI at Cambridge), who has won the 2025 European Young Researcher Award from the Fondation Recherche Alzheimer in France. 🎉👏
Read the full story 👉 tinyurl.com/243s9tuf
Read the full story 👉 tinyurl.com/243s9tuf
Reposted by Axel Montagne
The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.
Apply here 👇
bit.ly/4nm8csZ
Apply here 👇
bit.ly/4nm8csZ
Research Fellow
We are looking for an enthusiastic postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
September 24, 2025 at 3:35 PM
The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.
Apply here 👇
bit.ly/4nm8csZ
Apply here 👇
bit.ly/4nm8csZ
Reposted by Axel Montagne
The Edinburgh participants at dinner at VasCog!
September 18, 2025 at 5:50 AM
The Edinburgh participants at dinner at VasCog!
✨ Preorders are OPEN ✨
My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛
📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho
She’s poured her heart into this — every preorder, share, & boost means the world 🙌
My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛
📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho
She’s poured her heart into this — every preorder, share, & boost means the world 🙌
www.etsy.com
August 31, 2025 at 9:41 AM
✨ Preorders are OPEN ✨
My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛
📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho
She’s poured her heart into this — every preorder, share, & boost means the world 🙌
My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛
📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho
She’s poured her heart into this — every preorder, share, & boost means the world 🙌
Reposted by Axel Montagne
Happy 32nd Birthday to ApoE in Dementia research🎈
On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.
On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.
August 13, 2025 at 6:35 AM
Happy 32nd Birthday to ApoE in Dementia research🎈
On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.
On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.
Reposted by Axel Montagne
PhD position alert!
August 5, 2025 at 7:50 PM
PhD position alert!
Reposted by Axel Montagne
Serial block-face SEM of mouse Heart Capillaries #EndothelialCell #Pericyte #Telocyte
There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
August 5, 2025 at 11:17 AM
Serial block-face SEM of mouse Heart Capillaries #EndothelialCell #Pericyte #Telocyte
There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
Reposted by Axel Montagne
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
August 5, 2025 at 10:26 AM
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
Reposted by Axel Montagne
Just over a week left to apply for this position in our lab!
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
August 5, 2025 at 11:29 AM
Just over a week left to apply for this position in our lab!
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain
The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...
www.frontiersin.org
July 22, 2025 at 6:48 AM
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Reposted by Axel Montagne
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
July 10, 2025 at 11:08 AM
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Reposted by Axel Montagne
Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
July 16, 2025 at 7:39 AM
Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Axel Montagne
Amazing opportunity! specially looking for neurovascular research junior PIs!!
Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...
July 14, 2025 at 11:23 AM
Amazing opportunity! specially looking for neurovascular research junior PIs!!
Reposted by Axel Montagne
We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
June 24, 2025 at 4:08 PM
We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Reposted by Axel Montagne
🧠 New paper out in Biogerontology!
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
Circulating immune cells in cerebral small vessel disease: a systematic review - Biogerontology
Cerebral small vessel disease (cSVD) refers to all pathologies of the brain’s arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-im...
link.springer.com
May 10, 2025 at 5:42 AM
🧠 New paper out in Biogerontology!
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology
Reposted by Axel Montagne
Colleagues at Row Fogo Centre for Research into Ageing and the Brain (@svdresearch.bsky.social) have revealed how specific blood biomarkers may help predict the progression of cerebral small vessel disease — a major contributor to #stroke and #dementia.
Read the full paper: edin.ac/4cZfM8q
Read the full paper: edin.ac/4cZfM8q
Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study
INTRODUCTION This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped...
edin.ac
May 5, 2025 at 12:56 PM
Colleagues at Row Fogo Centre for Research into Ageing and the Brain (@svdresearch.bsky.social) have revealed how specific blood biomarkers may help predict the progression of cerebral small vessel disease — a major contributor to #stroke and #dementia.
Read the full paper: edin.ac/4cZfM8q
Read the full paper: edin.ac/4cZfM8q